link collection Our new site (membrane preparation, calcein assay, MDR1, MRP1, MRP2, MRP3, MRP4, BSEP) membrane transporter P-glycoprotein multidrug resistance chemotheraphy blood-brain barrier BBB assay transport screening ADME Absorption Distribution Metabolism Excretion early ADME in-vitro system drug metabolism nucleotide trapping dye transport bioavailability xenobiotics permeability cancer drug resistance hydrophobic drug drug interaction modulator pharmacokinetics CNS penetration modulator Ivermectin DMPK chemotherapy resistant tumor cell anticancer drug chemosensitizer lead optimization drug development HTS pharmacology Paclitaxel PSC833 cyclosporin A somatostatin somatostatin analogues Ivermectin indinavir deaxamethasone digoxin doxorubicin vecuronium azido-procainamide tributyltrimethylammonium rifampin tacrolimus vinblastine ondansteron quinidine verapamil loperamide CsA GG918 talinolol fexofenidine fexofenadine actinomycin D Vinca alkaloides taxanes anthracyclines epipodophyllotoxins antheacenes colchicine saquinavir ritonavir amprenavir nelfinavir lopinavir FK506 erythromycin domperidone cimetidine diltiazam morphine terfenidine terfenadine gramicidin D Rhodamine123 cortisol loperamide valinomycin talinolol Flavopiridol Genistein Isoflavone Quercetin amiloride amiodarone atorvastatin Chloroquine Chloropromazine Clofazimine cremophor EL daunorubicine daunomycine morpholine doxorubicine Diltiazem Dipyridamole Erythromycine Fluoroquinolones fleroxacin enoxacin grepafloxacin levofloxacin norfloxacine Glibenclamides Gramicidin Hydrocortisone Itraconazole Lidocaine propafenone propanolol quinine quinacrine cinchonine SDZ PSC 833 tamoxifene nifedipine bepridil nicardipine niguldipine nitrendipine trifluoperazine felodipine vincristine vindesine adriamycin aldosteron benzopyrene Calcein AM estradiol ethidium bromide etoposide teniposide fluo-3 Hoechst 33342 L-DOPA Losartan mithramycin mitomycin C docetaxel puromycin Tc99m sestamibi topotecan bergamottin clarithromycin dimetyl-ß-cyclodextrin GF120918 ketoconazole LY335979 midazolam progesterone RU 486 megestrol acetate testosterone XR 9576 XR 9051 3-methyl-cholanthrene phenothiazines prazosin membrane chemical toxicity oxidative stress inflammatory responses transporter multidrug-resistance glutathione GSH vesicular transport assay nucleotide trapping dye transport ADME Absorption Distribution Metabolism Excretion early ADME in-vitro system drug metabolism nucleotide trapping dye transport efflux transporter biovavailability xenobiotics toxicity screening cancer drug resistance hydrophobic drugs penetration pharmacological barrier drug interaction pharmacokinetics DMPK chemotherapy anticancer drug resistant tumor cell lead optimization HTS drug development pharmacology daunorubicin aflatoxin B1 aflatoxin B1-glutathione conjugate benzbromarone furosemide indomethacin LTC4 MK571 Penicillin G rifampicin RU 486 sulfinpyrazone doxorubicin clorambucil clorambucil-glutathione conjugate daunomycin daunomycin-glutathione conjugate daunorubicin daunorubicin-glutathione conjugate cyclosporin A genistein calcein AM membrane liver bile organic anion assay vesicular transport nucleotide trapping screening Dubin-Johnson bilirubin efflux transport organic anion transport ADME Distribution Metabolism Absorption Excretion early ADME in-vitro system drug metabolism multidrug resistance hydrophobic drugs penetration pharmacological barrier hepatobiliary secretion kidney secretion cancer drug resistance drug interaction bioavailability DMPK chemotherapy resistant tumor cell anticancer drug lead optimization drug development HTS pharmacology phenylimidazol[4,5-b]pyridine somatostatin GSH PhIP somatostatin analogues GSH conjugates CPT11 irinotecan endothelin 1 estradiol 17-ß-D-glucuronide grepafloxacine HIV protease inhibitor methotrexate PAH pravastatin probenecid BSP ouabain taxol telmisaltan calcein AM furosemide Penicillin G cefodizime cyclosporin A genistein glibenclamine indomethacin LTC4 MK-571 phenobarbital quinidine rifampicin sulfinpyrazone drug resistance screening vesicular transport assay ADME Absorption Distribution Metabolism Excretion early ADME in-vitro system drug metabolism drug interaction drug development organic ion efflux transport pharmacokinetics DMPK lead optimization HTS pharmacology glycocholate taurocholate 3H-E217bG 3H-Methotrexate 3H-Folic acid 3H-leucovorin furosemid benzbromarone indomethacine E217bG membrane assay screening nucleotide analogue transport ADME Absorption Distribution Metabolism Excretion early ADME in-vitro system drug metabolism pharmacology 3H-E217bG 3H-Methotrexate 3H-Folic acid 3H-Leucovorin 3H-DHEAS cGMP cAMP Methotrexate Zaprinast E217bG DHEAS Sulfinpyrazone MK-571 Probenecid pharmacology nucleoside transport 3H-cAMP 3H-6-SH-purine 3H-cGMP 3H-alaninyl-d4TMP Zaprinast Benzbromarone MK-571 Sulfinpyrazone Probenecid cGMP cAMP lead optimization HTS drug development membrane cancer drug resistance screening vesicular transport nucleotide trapping assay pharmacokinetics pharmacological barrier dye transport ADME Absorption Distribution Metabolism excretion early ADME in-vitro system drug metabolism drug interaction efflux transport xenobiotics DMPK chemotherapy anticancer drugs resistant tumor cells pharmacology topotecan mitoxantrone irinotecan SN-38 9-amino campto indolocarbazoles NB506 J-107088 Topo 1 inhibitors methotrexate anthracyclines Dox DNR IDA flavopiridol quinazolines HER tyrosine kinase inhibitor prazosine CI1033 fumitremorgin C FTC GF120918 prazocine iressa BIB-E novobiocin VX-710 VX853 estrogens tamoxifene membrane FXR bile salt intrahepatic cholestasis efflux transport cancer drug resistance screening vesicular transport drug interaction assay pharmacokinetics ADME Absorption Distribution Metabolism Excretion early ADME in-vitro system drug metabolism pharmacology bosentan troglitazone 3H-Taurocholate 3H-Glycocholate 3H-Taurochenodesoxycholate 3H-Tauroursodesoxycholate Taurochenodesoxycholate Glibenclamide Taurocholate Glycocholate Rifamicin SV Rifampicin Cyclosporin A Rifamicin SV Glibenclamide liver membrane lead optimization HTS pharmacology drug development fatty acid secretion modulators environmental toxicity ADME Absorption Distribution Metabolism Excretion early ADME in-vitro system drug metabolism nucleotide trapping assay phosphatidyl-choline transport 3H-Methyl-quinidine 3H-Methyl-quinine Verapamil Quinidine Erithromycin Prazosin Ritonavir Digoxin Doxorubicin Methotrexate Ranitidine 3H-E217bG 3H-LTC4 3H-Methotrexate 3H-BQ123 NEM-GS Probenecid Sulfinpyrazone Indomethacin Methotrexate Furosemid Benzbromarone MultiDrugQuantTM assay kit haematology solid tumor leukemia absorption ADME xenobiotics screening vesicular transport membrane membrane assay bioaccumulation multispecificity drug-drug interaction drug-drug interaction calcein assay ATPase assay efflux transport modulation multidrug resistance CSF penetration DMPK rapid filtration nucleotide trapping Sf 9 cells vesicular transport assay monolayer efflux assay vanadate dependent nucleotide trapping MDR1 ABCB1 PGP MDR2 ABCB2 ABCB4 ABCB5 ABCB6 ABCB7 cMOAT MRP3 ABCC3 cMOAT-2 MRP4 MRP5 MRP6 MRP7 MXR ABCG2 BCRP ABCP Bsep Abcb11 Spgp PGP3 PGP4 PGP5 PGP6 rMdr1b Rat Mdr1b rMrp2 Rat Mrp2 MDQkit MultiDrugQuant MultiDrugQuant MultiDrugQuant MultiDrugQuant ABC transporter multispecificity