31 July 2007

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PredivezTM Flyer


SOLVO Biotechnology is introducing the revolutionary

MRP2 PREDIVEZ TM Vesicular Transport kit


The PREDIVEZ™ Vesicular Transport kit is a simple and powerful tool to investigate drug-transporter interactions. It provides information on any interaction between the ABC transporter and the test drug that would affect the transport of the fluorescent reporter substrate. A representation of the assay is shown in the figure.



SOLVO's PREDIVEZ™ Kit is available in 3-, 6- and 9-compound sizes for MRP2

The Fluorescent PREDIVEZ™ Kit delivers major advantages over the conventional radioactive Vesicular Transport assay


The Sensitive and quick fluorescent measurement With the use of a fluorescent reporter substrate you can avoid the use of radioactive materials and lengthy scintillation counting

    Reproducible results
  • Low inter-assay variability
  • Z' factor for MRP2 is ~ 0.74
  • Increased automated system compatibility




Larger dynamic range / signal-to-background ratio compared to the radioactive Vesicular transport assay

The reporter substrate provides low non-specific binding, so you can get a larger signal and smaller standard deviations for your test compounds.



Flexible data analysis
Data can be presented in transport values (with the help of the calibration curve, included), or in percentages (see Figures below).
3 compounds in 8 concentrations can be screened using one 3-compound Kit.




Easy to use
All reagents to perform the assay are included!

Every kit comes with a CD containing important information about the PREDIVEZ assay:
  • Assay protocol
  • Excel data evaluation sheet
  • MSDSs
  • Reference curves with known interactors

    • Coming up:
  • ratMrp2 PREDIVEZ™ Kit (Q4 of 2007)
  • MRP3 PREDIVEZ™ Kit (Q4 of 2007)
  • MRP5 PREDIVEZ™ Kit (Q4 of 2007)
  • BSEP PREDIVEZ™ Kit (Q2 of 2008)
  • mouseBsep PREDIVEZ™ Kit (Q2 of 2008)


    • With our best regards,
    SOLVO Biotechnology
    Business Development Team



    How to order:

    For North American Customers (US & Canada):
    XenoTech LLC www.xenotexhllc.com


    For Customers in Japan:
    Funakoshi www.funakoshi.co.jp, Iwaki www.iwaki-kk.co.jp and Nosan www.nosan.co.jp


    For Customers in Europe and other countries:
    SOLVO Biotechnology www.solvo.com
    Fax: +36 23 503941
    Email:

    For Customers in Japan: Funakoshi (distributor of SOLVO membrane products) Iwaki (exclusive distributor of SOLVO Fee-for Service Screenings, distributor of SOLVO membrane products)
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