15 November 2007
SOLVO Biotechnology extended its PREDISCREEN™ portfolio with OATP-B (OATP2B1)/BCRP (MXR, ABCG2) double transfected cell line based monolayer package.
SOLVO new PrediScreen™ services apply MDCKII cell lines transfected with both BCRP and OATP-B. This combination models vectorial transport across hepatocytes as well as endothelial cells in the placenta. (Grube M et al. 2007., Grube M et al. 2006.). The single transfectants and the parental cell lines are also included in the package and they provide negative controls for the transport. SOLVO offers two setup groups, one for direct measurements and one for indirect inhibitory type measurements where the effect of test articles on the vectorial transport of a reference substrate can be examined. SOLVO also presents direct and indirect setups for BCRP and mouse Bcrp1 interactions on single transfectant cell lines for medium to high permeability test articles. The following tables and graphs summarize the details of these newly launched services.
For OATP-B mediated interactions we offer cellular uptake experiments both direct and inhibitory type.
For further information please use the following link:
http://www.solvo.com/pdfs/Vectorial%20transport%20_%207.pdf
With our best regards,
SOLVO Biotechnology
Business Development Team
CONTACT INFORMATION:
SOLVO Biotechnology
E-mail: 
Web: www.solvo.com
Phone: +36-23/503-940 Fax: +36-23/503-941 2 Gyár St. H-2040 Budaörs, HUNGARY
How to order:
For North American Customers (US & Canada):
XenoTech LLC www.xenotexhllc.com
For Customers in Japan:
Funakoshi www.funakoshi.co.jp,
Iwaki www.iwaki-kk.co.jp
and Nosan www.nosan.co.jp
For Customers in Europe and other countries:
SOLVO Biotechnology www.solvo.com
Fax: +36 23 503941
Email:
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For Customers in Japan:
Funakoshi (distributor of SOLVO membrane products)
Iwaki (exclusive distributor of SOLVO Fee-for Service Screenings, distributor of SOLVO membrane products)
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