SOLVO Scientific Publications

Reviews

1. Interaction of macrocyclic lactones with the multidrug transporters: the bases of the pharmacokinetics of lipid-like drugs
   A. Lespine, J. Dupuy, C. Borin, M. Alvinerie, C. Comera, T. Nagy, P. Krajcsi and S. Orlowski
   Curr Drug Metab, 2009 Mar; 10(3):272-288



2. ABCC2/Abcc2 - a multispecific transporter with dominant excretory functions
   K. Jemnitz, K. Heredi-Szabo, L Vereczkey and P. Krajcsi
   DRUG METAB REV,



3. Potentiation of MRP2/Mrp2-mediated Estradiol-17β-Glucuronide Transport by Drugs - A Concise Review
   K. Herédi Szabó, K. Jemnitz, E. Kis, E. Ioja, J. Jánossy, L. Vereczkey and P. Krajcsi
   CHEMISTRY & BIODIVERSITY, 2009 Nov; 6(11):1970-1974



4. Utilization of membrane vesicle preparations to study drug-ABC transporter interactions.
   Glavinas H, Méhn D, Jani M, Oosterhuis B, Herédi-Szabó K, Krajcsi P
   Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):721-32.



5. The role of ABC transporters in drug resistance, metabolism and toxicity.
   Glavinas H, Krajcsi P, Cserepes J, Sarkadi B
   Curr Drug Deliv. 2004 Jan;1(1):27-42. Review.



6. Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays
   Csilla Hegedűs, Gergely Szakács, László Homolya, Tamás I. Orbán, Ágnes Telbisz, Márton Jani and Balázs Sarkadi
   Advanced Drug Delivery Reviews 61: 47-56 (2009)

Role of transporters in drug ADME

1. A novel screening strategy to identify ABCB1 substrates and inhibitors
   O. von Richter, H. Glavinas, P. Krajcsi, S. Liehner, B. Siewert, K. Zech
   Naunyn Schmiedebergs Arch PharmacoL 2009 Jan; 779(1):11-26



2. Comparative analysis of human multidrug resistanceassociated protein 2 (MRP2) and rat MRP2
   Krajcsi P, Glavinas H, Kis E, Kovács R, Pal A
   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 25S1 (2005) S1–S226



3. Leflunomide and A771726, its metabolite are high affinity substrates of BCRP - implications for drug resistance.
   Kis E, Nagy T, Jani M, Molnár E, Jánossy J, Ujhelly O, Német K, Herédi-Szabó K, Krajcsi P
   Ann Rheum Dis. 2008 Apr 8. [Epub ahead of print]



4. Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4.
   Heredi-Szabo K, Kis E, Molnar E, Gyorfi A, Krajcsi P
   J Biomol Screen. 2008 Apr;13(4):295-301. Epub 2008 Mar 18.



5. [In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions]
   Pál A, Kis E, Méhn D, Glavinas H, Nagy T, Mészáros P, Báthori G, Krajcsi P, Falkay G
   Acta Pharm Hung. 2007;77(4):205-16. Hungarian.



6. Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes.
   Lengyel G, Veres Z, Tugyi R, Vereczkey L, Molnár T, Glavinas H, Krajcsi P, Jemnitz K.
   Hepatol Res. 2008 Mar;38(3):300-9. Epub 2007 Aug 29.



7. ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions.
   Glavinas H, Kis E, Pál A, Kovács R, Jani M, Vági E, Molnár E, Bánsághi S, Kele Z, Janáki T, Báthori G, von Richter O, Koomen GJ, Krajcsi P
   Drug Metab Dispos. 2007 Sep;35(9):1533-42. Epub 2007 May 30.



8. Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2.
   Pál A, Méhn D, Molnár E, Gedey S, Mészáros P, Nagy T, Glavinas H, Janáki T, von Richter O, Báthori G, Szente L, Krajcsi P
   J Pharmacol Exp Ther. 2007 Jun;321(3):1085-94. Epub 2007 Mar 8.



9. Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp).
   Schmitt U, Abou El-Ela A, Guo LJ, Glavinas H, Krajcsi P, Baron JM, Tillmann C, Hiemke C, Langguth P, Härtter S
   J Neural Transm. 2006 Jul;113(7):787-801. Epub 2005 Oct 27.

Role of transporters in nutrition, bioavailability and in risk assessement of environmental toxicants

1. Mechanistic study on the intestinal absorption and disposition of baicalein.
   Zhang L, Lin G, Kovács B, Jani M, Krajcsi P, Zuo Z
   Eur J Pharm Sci. 2007 Jul;31(3-4):221-31. Epub 2007 Apr 9.



2. Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).
   Williamson G, Aeberli I, Miguet L, Zhang Z, Sanchez MB, Crespy V, Barron D, Needs P, Kroon PA, Glavinas H, Krajcsi P, Grigorov M
   Drug Metab Dispos. 2007 Aug;35(8):1262-8. Epub 2007 May 3.



3. Specific interactions of chloroacetanilide herbicides with human ABC transporter proteins.
   Oosterhuis B, Vukman K, Vági E, Glavinas H, Jablonkai I, Krajcsi P
   Toxicology. 2008 Jun 3;248(1):45-51. Epub 2008 Mar 14.



4. Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3).
   Lespine A, Dupuy J, Orlowski S, Nagy T, Glavinas H, Krajcsi P, Alvinerie M
   Chem Biol Interact. 2006 Feb 25;159(3):169-79. Epub 2005 Dec 27.

Miscellaneous

1. Characterisation of a GroEL Single-Ring Mutant that Supports Growth of Escherichia coli and Has GroES-Dependent ATPase Activity.
   Kovács E, Sun Z, Liu H, Scott DJ, Karsisiotis AI, Clarke AR, Burston SG, Lund PA.
   J Mol Biol. 2009 dec



2. Effect of membrane cholesterol on BSEP/Bsep activity - species specificity studies for substrates and inhibitors
   E. Kis, E. Ioja, T. Nagy, K. Herédi-Szabó and P. Krajcsi
   DRUG METAB DISPOS, 2009 Sep; 37(9): 1878-86.



3. MRP2-mediated E2-17βG transport potentiation: in vitro - in vivo correlation and species specificity
   K. Heredi-Szabo, H. Glavinas, E. Kis, D. Méhn, G. Báthori, Z. Veres, L. Kóbori, O. von Richter, K. Jemnitz and P. Krajcsi
   DRUG METAB DISPOS, 2009 Apr; 37(4):794-781



4. Kinetic characterization of sulfasalazine transport by human ABCG2 (BCRP)
   M. Jani, P. Szabó, E. Kis, É. Molnár, H. Glavinas, P. Krajcsi
   Biol PhARM BULL, 2009 Mar; 32(3):497-99



5. Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs
   E. Kis, Z. Rajnai, E. Ioja, K. Herédi-Szabó, T. Nagy, D. Méhn and P. Krajcsi
   J BIOMOL SCREEN, 2009 Jan; 14(1):10-15



6. Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells
   Özvegy Cs, Litman T, Szakács G, Nagy Z, Bates S, Váradi A, and Sarkadi B
   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2001, 285, 111–117



7. Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.
   Cserepes J, Szentpetery Z, Seres L, Ozvegy-Laczka C, Langmann T, Schmitz G, Glavinas H, Klein I, Homolya L, Varadi A, Sarkadi B, Elkind NB
   Biochem Biophys Res Commun. 2004 Jul 30;320(3):860-7.



8. Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties.
   Fantin M, Quintieri L, Kúsz E, Kis E, Glavinas H, Floreani M, Padrini R, Duda E, Vizler C
   Eur J Pharmacol. 2006 Mar 27;535(1-3):301-9.

Book chapters


9. ABC transporters in the blood-brain barrier - relevance in stroke therapy in Recent advances and new strategies in stroke research
   In: Recent advances and new strategies in stroke research (editors: Z Nagy, F Erdo)
   M. Bollók, J. Jánossy and P. Krajcsi
   2008, Transworld Research Network, Kerala, pp167-190



10. Microdialysis techniques in stroke research:
    Experimental and clinical aspects
    In: Recent advances and new strategies in stroke research (editors: Z Nagy, F Erdo)
    F Erdő, F Andrási and I Sziráki
    2008, Transworld Research Network, Kerala, pp291-317

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