Uptake transporter assays
Uptake transporters play a key role in the pharmacokinetic profile of many structurally unrelated drugs. Present at all important pharmacological barrier tissues these proteins enable the translocation of medium to low permeability drug substances across plasma membranes and thereby determine absorption, distribution and elimination routing.
Testing for interactions with uptake transporters has the potential to predict the main factors in the system level movement of drugs.
SOLVO Biotechnology has developed a wide range of stably transfected cell lines for studying the interaction of test articles with uptake transporters.
For more details on SOLVO’s uptake transporter assays and scientific background of clinically relevant uptake transporters, please click here.
Services, ready-to-use products and licensing of cell lines are available.
| Transporter | Cell type | Service | PREDICELL™ | Licence |
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OATP1B1 (SLCO1B1/ OATP2, OATP-C) |
CHO |
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OATP1B3 (SLCO1B3/OATP8) |
CHO |
|
|
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OATP2B1 (SLCO2B1/OATP-B) |
MDCKII |
|
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|
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ratOatp1a1 (Slco1a1) |
CHO |
|
|
|
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NTCP (SLC10A1) |
CHO |
|
|
|
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ratNtcp (Slc10a1) |
CHO |
|
|
|
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PEPT1 (SLC15A1) |
CHO |
|
|
|
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PEPT2 (SLC15A2) |
CHO |
|
|
|
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OAT1 (SLC22A6) |
CHO |
|
|
|
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OAT3 (SLC22A8) |
CHO |
|
|
|
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OAT3 (SLC22A8) |
HEK293 |
|
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OCT1 (SLC22A1) |
CHO |
|
|
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OCT2 (SLC22A2) |
CHO |
|
|
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SOLVO'S uptake transporter portfolio is continuously expanding.
Please call us for more information.
Custom development of other transfected cell lines is also available from SOLVO.