Recent Developments

SOLVO is continuously expanding its product and service portfolio, with 10-20 new launches annually. Our focus is to develop new products and services based on the latest results in drug transporter science, the needs of the pharmaceutical industry and suggestion of the various regulatory agencies such as FDA and EMA regarding transporter related drug drug interaction studies.

You can easily catch up with our latest developments by visiting this page which summarizes the newest offerings in our portfolio.

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Service and Product Launches

2016-Q3

Vesicular Transport Membranes - Vesicular Transport Assays

MDR1-HEK293-VT

2016-Q2

Uptake Transporter Assays

SGLT2-HEK293

2016-Q1

Vesicular Transport Membranes - Vesicular Transport Assays

MRP3-HEK293
BCRP-HEK293

2015-Q3

Vesicular Transport Membranes - Vesicular Transport Assays

  ratMrp3-HEK293 VT
  ratMdr1b-HAM Sf9 VT
  mouseMdr1a-HEK293 VT

2015-Q2

Uptake Transporter Servicesinhibition and substrate assessment studies
 
  MDCKII-CNT1
  MDCKII-CNT2
  MDCKII-CNT3
  MDCKII-ENT1
  MDCKII-ENT2

Vesicular Transport Membranes

  BSEP-HEK293 VT

Vesicular Transport Membranes

  BCRP-HEK293 VT

Uptake Transporter Servicesinhibition and substrate assessment studies
 
  HEK293-OATP1B1 - Olmesartan and Estrone-3-sulfate as probe substrate

LLC-PK1 MonolayerAssays

  LLC-PK1-rMdr1a

2015-Q1

Vesicular Transport Membranes

  MRP3-HEK293 VT

LLC-PK1 MonolayerAssays

  LLC-PK1-BCRP

2014-Q4

Vesicular Transport Membranes - Vesicular Transport Assays

  ratBsep-HEK293 VT

2014-Q3

Sandwich-cultured hepatocyte services

  Sandwich-cultured hepatocyte services certified by Qualyst

Renal Proximal Tubule Cell Monolayer Assay

  Renal Proximal Tubule Cell Monolayer Assay in collaboration with NewCastle University

2014-Q2

PreadyPort Product line

    PreadyPort-BCRP-OATP2B1 24- and 96-well plates

2013-Q4

LC/MS-MS Quantification of Transporter Proteins

PREDICELL Product line

    MATE2K-PREDICELL
    NTCP-PREDICELL
    OAT3-PREDICELL
    OCTN1-PREDICELL
   
Uptake Transporter Servicesinhibition and substrate assessment studies

  HEK-ratOatp1b2 - Taurocholate as probe substrate

2013-Q3

MDCKII Monolayer Assays

  MDCKII-OAT1/BCRP: a renal vectorial transport model

PREDICELL Product line

    MATE1-PREDICELL
    OCT1-PREDICELL
    OCTN2-PREDICELL

2013-Q2

Molecular Imaging - Preclinical and Clinical PET & PET tracer synthesis (collaboration with AIT)

Uptake Transporter Servicesinhibition and substrate assessment studies

    MDCKII-MATE1 - TEA and metformin as probe substrates
    MDCKII-OAT3 - E3S as probe substrate

2013-Q1

Uptake Transporter Servicesinhibition and substrate assessment studies

    MDCKII-MATE2 - TEA and metformin as probe substrates
    CHO-OCT2 - MPP+ as probe substrate

PreadyPort Product line

    PreadyPort-BCRP 96-well plates

Membrane Product

    BSEP-Hi5 VT membrane

Publications

2013-Q2

  • MDR-ABC transporters: biomarkers in rheumatoid arthritis.
  • Márki-Zay J, Tauberné Jakab K, Szerémy P, Krajcsi P.
    Clin Exp Rheumatol. 2013 May 27. [Epub ahead of print]

  • Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3.
  • Juhász V, Beéry E, Nagy Z, Bui A, Molnár E, Zolnerciks JK, Magnan R, Jani M, Krajcsi P.
    J Pharm Sci. 2013 May;102(5):1683-7

  • A P-gp vesicular transport inhibition assay - Optimization and validation for drug-drug interaction testing.
  • Herédi-Szabó K, Palm JE, Andersson TB, Pál A, Méhn D, Beéry E, Jakab KT, Jani M, Krajcsi P.
    Eur J Pharm Sci. 2013 May 15

  • Application of Receiver Operating Characteristic (ROC) Analysis to Refine the Prediction of Potential Digoxin Drug Interactions.
  • Ellens H, Deng S, Coleman J, Bentz J, Taub ME, Ragueneau-Majlessi I, Chung S, Heredi-Szabo K, Neuhof S, Palm JE, Balimane P, Zhang L, Jamei M, Hanna IH, O’Connor M, Bednarczyk D, Forsgard M, Chu X, Funk C, Guo A, Hillgren KM, Li L, Pak A, Perloff E, Rajaraman G, Salphati L, Taur J, Weitz D, Wortelboer H, Xia C, Xiao G, Yamagata T, Lee CA.
    Drug Metab Dispos. 2013 Apr 25

    2012-Q4

  • The vesicular transport assay: validated in vitro methods to study drug-mediated inhibition of canalicular efflux transporters ABCB11/BSEP and ABCC2/MRP2.
  • Herédi-Szabó K, Kis E, Krajcsi P. Curr Protoc Toxicol. 2012 Nov;Chapter 23:Unit 23.4.

  • The Use of Microdialysis Techniques in Mice to Study P-gp Function at the Blood-Brain Barrier.
  • Sziráki I, Erdo F, Trampus P, Sike M, Molnár PM, Rajnai Z, Molnár J, Wilhelm I, Fazakas C, Kis E, Krizbai I, Krajcsi P. J Biomol Screen. 2012 Dec 26. [Epub ahead of print]