The new FDA Draft Guidance for Transporter DDI is out now Go

Publications

Reviews

  1. ABCC2/Abcc2 - a multispecific transporter with dominant excretory functions
    2. K. Jemnitz, K. Heredi-Szabo, L Vereczkey and P. Krajcsi
    Drug Metab Rev. 2010 Aug;42(3):402-36.
  2. Potentiation of MRP2/Mrp2-mediated Estradiol-17β-Glucuronide Transport by Drugs - A Concise Review
    3. K. Herédi Szabó, K. Jemnitz, E. Kis, E. Ioja, J. Jánossy, L. Vereczkey and P. Krajcsi
    Chem Biodivers. 2009 Nov;6(11):1970-4.
  3. Interaction of macrocyclic lactones with the multidrug transporters: the bases of the pharmacokinetics of lipid-like drugs
    4. A. Lespine, J. Dupuy, C. Borin, M. Alvinerie, C. Comera, T. Nagy, P. Krajcsi and S. Orlowski
    Curr Drug Metab. 2009 Mar;10(3):272-88.
  4. Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays
    5. Csilla Hegedűs, Gergely Szakács, László Homolya, Tamás I. Orbán, Ágnes Telbisz, Márton Jani and Balázs Sarkadi
    Adv Drug Deliv Rev. 2009 Jan 31;61(1):47-56. Epub 2008 Dec 24.
  5. Utilization of membrane vesicle preparations to study drug-ABC transporter interactions
    6. Glavinas H, Méhn D, Jani M, Oosterhuis B, Herédi-Szabó K, Krajcsi P
    Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):721-32.
  6. The role of ABC transporters in drug resistance, metabolism and toxicity
    7. Glavinas H, Krajcsi P, Cserepes J, Sarkadi B
    Curr Drug Deliv. 2004 Jan;1(1):27-42.

Role of transporters in drug ADME

  1. Digoxin is not a Substrate for Organic Anion Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a Substrate for a Sodium Dependent Transporter Expressed in HEK293 Cells
    2. Taub ME, Mease KM, Sane RS, Watson CA, Chen L, Ellens H, Hirakawa BP, Reyner EL, Jani M, Lee CA. Drug Metab Dispos. 2011 Aug 17.
  2. Quinidine as an ABCB1 Probe for Testing Drug Interactions at the Blood-Brain Barrier: An In Vitro In Vivo Correlation Study
    3. Sziráki I, Erdo F, Beéry E, Molnár PM, Fazakas C, Wilhelm I, Makai I, Kis E, Herédi-Szabó K, Abonyi T, Krizbai I, Tóth GK, Krajcsi P. J Biomol Screen. 2011 Aug 10.
  3. Calcein assay: a high-throughput method to assess P-gp inhibition
    4. Glavinas H, von Richter O, Vojnits K, Mehn D, Wilhelm I, Nagy T, Janossy J, Krizbai I, Couraud P, Krajcsi P. Xenobiotica. 2011 Aug;41(8):712-9. Epub 2011 Jun 9.
  4. Comparison of 3 Assay Systems Using a Common Probe Substrate, Calcein AM, for Studying P-gp Using a Selected Set of Compounds
    5. Szerémy P, Pál A, Méhn D, Tóth B, Fülöp F, Krajcsi P, Herédi-Szabó K.
    J Biomol Screen. 2010 Nov 5.
  5. ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor
    6. Zsuzsanna Rajnai, Dóra Méhn, Erzsébet Beéry, Alper Okyar, Márton Jani, Gábor K. Tóth, Ferenc Fülöp, Francis Lévi and Peter Krajcsi
    Drug Metab Dispos. 2010 Nov;38(11):2000-6. Epub 2010 Aug 10.
  6. MRP2-mediated E2-17βG transport potentiation: in vitro - in vivo correlation and species specificity
    7. K. Heredi-Szabo, H. Glavinas, E. Kis, D. Méhn, G. Báthori, Z. Veres, L. Kóbori, O. von Richter, K. Jemnitz and P. Krajcsi
    Drug Metab Dispos. 2009 Apr;37(4):794-801. Epub 2008 Dec 31.
  7. Kinetic characterization of sulfasalazine transport by human ABCG2 (BCRP)
    8. M. Jani, P. Szabó, E. Kis, É. Molnár, H. Glavinas, P. Krajcsi
    Biol Pharm Bull. 2009 Mar;32(3):497-9.
  8. Leflunomide and A771726, its metabolite are high affinity substrates of BCRP - implications for drug resistance
    9. Kis E, Nagy T, Jani M, Molnár E, Jánossy J, Ujhelly O, Német K, Herédi-Szabó K, Krajcsi P
    Ann Rheum Dis. 2009 Jul;68(7):1201-7. Epub 2008 Apr 8.
  9. A novel screening strategy to identify ABCB1 substrates and inhibitors
    10. O. von Richter, H. Glavinas, P. Krajcsi, S. Liehner, B. Siewert, K. Zech
    Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. Epub 2008 Aug 29.
  10. Characterization of 5(6)-carboxy-2,‘7’-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4
    11. Heredi-Szabo K, Kis E, Molnar E, Gyorfi A, Krajcsi P
    J Biomol Screen. 2008 Apr;13(4):295-301. Epub 2008 Mar 18.
  11. In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions
    12. Pál A, Kis E, Méhn D, Glavinas H, Nagy T, Mészáros P, Báthori G, Krajcsi P, Falkay G
    Acta Pharm Hung. 2007;77(4):205-16.
  12. Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes
    13. Lengyel G, Veres Z, Tugyi R, Vereczkey L, Molnár T, Glavinas H, Krajcsi P, Jemnitz K.
    Hepatol Res. 2008 Mar;38(3):300-9. Epub 2007 Aug 29.
  13. ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions
    14. Glavinas H, Kis E, Pál A, Kovács R, Jani M, Vági E, Molnár E, Bánsághi S, Kele Z, Janáki T, Báthori G, von Richter O, Koomen GJ, Krajcsi P
    Drug Metab Dispos. 2007 Sep;35(9):1533-42. Epub 2007 May 30.
  14. Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2
    15. Pál A, Méhn D, Molnár E, Gedey S, Mészáros P, Nagy T, Glavinas H, Janáki T, von Richter O, Báthori G, Szente L, Krajcsi P
    J Pharmacol Exp Ther. 2007 Jun;321(3):1085-94. Epub 2007 Mar 8.
  15. Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)
    16. Schmitt U, Abou El-Ela A, Guo LJ, Glavinas H, Krajcsi P, Baron JM, Tillmann C, Hiemke C, Langguth P, Härtter S
    J Neural Transm. 2006 Jul;113(7):787-801. Epub 2005 Oct 27.
  16. Comparative analysis of human multidrug resistance associated protein 2 (MRP2) and rat MRP2
    17. Krajcsi P, Glavinas H, Kis E, Kovács R, Pal A
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 25S1 (2005) S1–S226
  17. Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells
    18. Özvegy Cs, Litman T, Szakács G, Nagy Z, Bates S, Váradi A, and Sarkadi B
    Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7.
  18. Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization
    19. Cserepes J, Szentpetery Z, Seres L, Ozvegy-Laczka C, Langmann T, Schmitz G, Glavinas H, Klein I, Homolya L, Varadi A, Sarkadi B, Elkind NB
    Biochem Biophys Res Commun. 2004 Jul 30;320(3):860-7.

Role of transporters in in drug toxicity

  1. Effect of membrane cholesterol on BSEP/Bsep activity - species specificity studies for substrates and inhibitors
    2. E. Kis, E. Ioja, T. Nagy, K. Herédi-Szabó and P. Krajcsi
    Drug Metab Dispos. 2009 Sep;37(9):1878-86. Epub 2009 Jun 11.
  2. Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs
    3. E. Kis, Z. Rajnai, E. Ioja, K. Herédi-Szabó, T. Nagy, D. Méhn and P. Krajcsi
    J Biomol Screen. 2009 Jan;14(1):10-5. Epub 2008 Nov 21.

Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

  1. Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1
    2. Dreiseitel A, Oosterhuis B, Vukman KV, Schreier P, Oehme A, Locher S, Hajak G, Sand PG
    Br J Pharmacol. 2009 Dec;158(8):1942-50.
  2. Specific interactions of chloroacetanilide herbicides with human ABC transporter proteins
    3. Oosterhuis B, Vukman K, Vági E, Glavinas H, Jablonkai I, Krajcsi P
    Toxicology. 2008 Jun 3;248(1):45-51. Epub 2008 Mar 14.
  3. Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2)
    4. Williamson G, Aeberli I, Miguet L, Zhang Z, Sanchez MB, Crespy V, Barron D, Needs P, Kroon PA, Glavinas H, Krajcsi P, Grigorov M
    Drug Metab Dispos. 2007 Aug;35(8):1262-8. Epub 2007 May 3.
  4. Mechanistic study on the intestinal absorption and disposition of baicalein
    5. Zhang L, Lin G, Kovács B, Jani M, Krajcsi P, Zuo Z
    Eur J Pharm Sci. 2007 Jul;31(3-4):221-31. Epub 2007 Apr 9.
  5. Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3)
    6. Lespine A, Dupuy J, Orlowski S, Nagy T, Glavinas H, Krajcsi P, Alvinerie M
    Chem Biol Interact. 2006 Feb 25;159(3):169-79. Epub 2005 Dec 27.

Miscellaneous

  1. Characterisation of a GroEL Single-Ring Mutant that Supports Growth of Escherichia coli and Has GroES-Dependent ATPase Activity
    2. Kovács E, Sun Z, Liu H, Scott DJ, Karsisiotis AI, Clarke AR, Burston SG, Lund PA.
    J Mol Biol. 2010 Mar 12;396(5):1271-83. Epub 2009 Dec 16.
  2. Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties
    3. Fantin M, Quintieri L, Kúsz E, Kis E, Glavinas H, Floreani M, Padrini R, Duda E, Vizler C
    Eur J Pharmacol. 2006 Mar 27;535(1-3):301-9.

Book chapters

  1. ABC transporters in the blood-brain barrier - relevance in stroke therapy in Recent advances and new strategies in stroke research
    2. In: Recent advances and new strategies in stroke research (editors: Z Nagy, F Erdo)
    M. Bollók, J. Jánossy and P. Krajcsi
    2008, Transworld Research Network, Kerala, pp167-190
  2. Microdialysis techniques in stroke research: Experimental and clinical aspects
    3. In: Recent advances and new strategies in stroke research (editors: Z Nagy, F Erdo)
    F Erdő, F Andrási and I Sziráki
    2008, Transworld Research Network, Kerala, pp291-317

Relevant Scientific Publications

1. Endicott, J.A. and Ling, V. Annu.Rev.Biochem., 1989, 58, 137-171.

2. Higgins, C.F. Ann.Rev.Cell Biol., 1992, 8, 67-113.

3. Gottesman, M.M. and Pastan, I. Annu.Rev.Biochem., 1993, 62, 385-427.

4. Gottesman, M.M.; Fojo, T.; Bates, S.E. Nat. Rev. Cancer, 2002, 2 (1), 48-58.

5. Klein, I.; Sarkadi, B.; Váradi, A. Biochim. Biophys. Acta, 1999, 1461 (2), 237-262.

6. Ueda, K.; Taguchi, Y.; Morishima, M. Semin Cancer Biol., 1997, 8 (3), 151-159.

7. Váradi, A.; Tusnády, G.E.; Sarkadi, B. In ABC Proteins From Bacteria to Man, Holland, I.B.; Cole, S.P.C.; Kuchler, K.; Higgins, C.F. Ed.; Elsevier Science, 2003, pp. 37-47.

8. Karpowich, N.; Martsinkevich, O.; Millen, L.; Yuan, Y.R.; Dai, P.L.; MacVey, K.; Thomas, P.J.; Hunt, J.F. Structure, 2001, 9 (7), 571-86.

9. Dean, M.; Rzhetsky, A.; Allikmets, R. Genome Res., 2001, 11 (7), 1156-1166.

10. Linton, K.J.; Rosenberg, MF.; Kerr, I.D.; Higgins, C.F. In ABC Proteins From Bacteria to Man, Holland, I.B.; Cole, S.P.C.; Kuchler, K.; Higgins, C.F. Ed.; Elsevier Science, 2003, pp. 65-80

11. Bates, S. In ABC Proteins From Bacteria to Man, Holland, I.B.; Cole, S.P.C.; Kuchler, K.; Higgins, C.F. Ed.; Elsevier Science, 2003, pp. 359-391.

12. Arnould, I.; Schriml, L.; Prades, C.; Lachtermacher-Triunfol, M.; Schneider, T.; Maintoux, C. GeneScreen, 2001, 1, 157-164.

13. Young, S.G. and Fielding, C.J. Nat. Genet, 1999, 22 (4), 316-318.

14. Bodzioch, M.; Orso, E.; Klucken, J.; Langmann, T.; Bottcher, A.; Diederich, W.; Drobnik, W.; Barlage, S.; Buchler, C.; Porsch-Ozcurumez, M.; Kaminski, W.E.; Hahmann, H.W.; Oette, K.; Rothe, G.; Aslanidis, C.; Lackner, K.J.; Schmitz, G. Nat Genet. 1999, 22 (4), 347-51.

15. Rust, S.; Rosier, M.; Funke, H.; Real, J.; Amoura, Z.; Piette, J.C.; Deleuze, J.F.; Brewer, H.B.; Duverger, N.; Denefle, P.; Assmann, G. Nat Genet., 1999, 22 (4), 352-5.

16. Kaminski, W.E.; Orso, E.; Diederich, W.; Klucken, J.; Drobnik, W.; Schmitz, G. Biochem Biophys Res Commun., 2000, 273 (2), 532-8.

17. Allikmets, R.; Singh, N.; Sun, H.; Shroyer, N.F.; Hutchinson, A.; Chidambaram, A.; Gerrard, B.; Baird, L.; Stauffer, D.; Peiffer, A.; Rattner, A.; Smallwood, P.; Li, Y.; Anderson, K.L.; Lewis, R.A.; Nathans, J.; Leppert, M.; Dean, M.; Lupski, J.R. Nat. Genet, 1997, 15 (3), 236-246.

18. Allikmets, R. Am. J. Hum. Genet., 2000, 67 (4), 793-799.

19. Juliano, R.L. and Ling, V.A. Biochim. Biophys. Acta, 1976, 455 (1), 152-162.

20. Thiebaut, F.; Tsuruo, T.; Hamada, H.; Gottesman, M.M.; Pastan, I.; Willingham, M.C. Proc. Natl. Acad. Sci. U S A. 1987, 84 (21) 7735-7738.

21. Abele, R.; Tampe, R. Biochim Biophys Acta. 1999 1461 (2), 405-19.

22. van Helvoort, A.; Smith, A.J.; Sprong, H.; Fritzsche, I.; Schinkel, A.H.; Borst, P.; van Meer, G. Cell, 1996, 87 (3), 507-517.

23. Deleuze, J.F.; Jacquemin, E.; Dubuisson, C.; Cresteil, D.; Dumont, M.; Erlinger, S.; Bernard, O.; Hadchouel, M. Hepatology, 1996, 23 (4) 904-8.

24. de Vree, J.M.; Jacquemin, E.; Sturm, E.; Cresteil, D.; Bosma, P.J.; Aten, J.; Deleuze, J.F.; Desrochers, M.; Burdelski, M.; Bernard, O.; Oude Elferink, R.P.; Hadchouel, M. Proc Natl Acad Sci U S A., 1998, 6, 95 (1) 282-7.

25. Strautnieks, S.S.; Bull, L.N.; Knisely, A.S.; Kocoshis, S.A.; Dahl, N.; Arnell, H.; Sokal, E.; Dahan, K.; Childs, S.; Ling, V.; Tanner, M.S.; Kagalwalla, A.F.; Nemeth, A.; Pawlowska, J.; Baker, A.; Mieli-Vergani, G.; Freimer, N.B.; Gardiner, R.M.; Thompson, R.J. Nat. Genet. 1998, 20 (3), 233-238.

26. Zhang, F.; Zhang, W.; Liu, L.; Fisher, C.L.; Hui, D.; Childs, S.; Dorovini-Zis, K.; Ling, V. J Biol Chem. 2000, 275 (30), 23287-94.

27. Cole, S.P.; Bhardwaj, G.; Gerlach, J.H.; Mackie, J.E.; Grant, C.E.; Almquist, K.C.; Stewart, A.J.; Kurz, E.U.; Duncan, A.M.; Deeley, R.G. Science, 1992, 258 (5088), 1650-1654.

28. Borst, P.; Evers, R.; Kool, M.; Wijnholds, J. J. Natl. Cancer. Inst., 2000, 92 (16), 1295-1302.

29. Deeley, R.G. and Cole, S.P.C. Semin.Cancer Biol., 1997, 8 (3), 193-204.

30. Paulusma, C.C.; Bosma, P.J.; Zaman, G.J.; Bakker, C.T.; Otter, M.; Scheffer, G.L.; Scheper, R.J.; Borst, P.; Oude Elferink, R.P. Science, 1996, 271 (5252), 1126-1128.

31. Cole, S.P.; Sparks, K.E.; Fraser, K.; Loe, D.W.; Grant, C.E.; Wilson, G.M.; Deeley, R.G. Cancer Res., 1994, 54 (22), 5902-10.

32. Leslie, E.M.; Deeley, R.G.; Cole, S.P. Toxicology. 2001, 167, (1), 3-23.

33. Kartenbeck, J.; Leuschner, U.; Mayer, R.; Keppler, D. Hepatology, 1996, 23 (5),1061-6.

34. Paulusma, C.C.; Kool, M.; Bosma, P.J.; Scheffer, G.L.; ter Borg, F.; Scheper, R.J.; Tytgat, G.N.; Borst, P.; Baas, F.; Oude Elferink, R.P. Hepatology, 1997, 25 (6), 1539-1542.

35. Kool, M.; van der Linden, M.; de Haas, M.; Scheffer, G.L.; de Vree, J.M.; Smith, A.J.; Jansen, G.; Peters, G.J.; Ponne, N.; Scheper, R.J.; Elferink, R.P.; Baas, F.; Borst, P. Proc Natl Acad Sci USA, 1999, 96 (12), 6914-9.

36. Konig, J.; Rost, D.; Cui, Y.; Keppler, D. Hepatology, 1999, 29 (4),1156-63

37. Schuetz, J.D.; Connelly, M.C.; Sun, D.; Paibir, S.G.; Flynn, P.M.; Srinivas, R.V.; Kumar. A.; Fridland, A. Nat. Med., 1999, 5, (9) 1048-51.

38. Rius, M.; Nies, A.T.; Hummel-Eisenbeiss, J.; Jedlitschky, G.; Keppler, D. Hepatology. 2003, 38 (2), 374-84.

39. Wijnholds, J.; Mol, C.A.; van Deemter, L.; de Haas, M.; Scheffer, G.L.; Baas, F.; Beijnen, J.H.; Scheper, R.J.; Hatse, S.; De Clercq, E.; Balzarini, J.; Borst, P. Proc. Natl. Acad. Sci. U S A., 2000, 97, (13) 7476-81.

40. Ilias, A.; Urban, Z.; Seidl, T.L.; Le Saux, O.; Sinko, E.; Boyd, C.D.; Sarkadi, B.; Varadi, A. J. Biol. Chem., 2002, 277 (19), 16860-7.

41. Belinsky, M.G.; Chen, Z.S.; Shchaveleva, I.; Zeng, H.; Kruh, G.D. Cancer Research, 2002, 62 (21), 6172-7.

42. Tammur, J.; Prades, C.; Arnould, I.; Rzhetsky, A.; Hutchinson, A.; Adachi, M.; Schuetz, J.D.; Swoboda, K.J.; Ptacek, L.J.; Rosier, M. Dean, M.; Allikmets, R. Gene. 2001, 273 (1):89-96.

43. Rommens, J.M.; Iannuzzi, M.C.; Kerem, B.; Drumm, M.L.; Melmer, G.; Dean, M.; Rozmahel, R.; Cole, J.L.; Kennedy, D.; Hidaka, N.; et al. Science, 1989, 245 (4922), 1059-65.

44. Hanrahan, J.W.; Gentzsch, M.; Riordan, J.R. In ABC Proteins From Bacteria to Man, Holland, I.B.; Cole, S.P.C.; Kuchler, K.; Higgins, C.F. Ed.; Elsevier Science, 2003, pp. 589-618.

45. Aguilar-Bryan, L.; Nichols, C.G.; Wechsler, S.W.; Clement, J.P.; Boyd, A.E.; Gonzalez, G.; Herrera-Sosa, H.; Nguy, K.; Bryan, J.; Nelson, D.A. Science. 1995, 268 (5209), 423-6.

46. Mosser, J.; Douar, A.M.; Sarde, C.O.; Kioschis, P.; Feil, R.; Moser, H.; Poustka, A.M.; Mandel, J.L.; Aubourg, P. Nature, 1993, 361 (6414), 726-730.

47. Chen, H.; Rossier, C.; Lalioti, M.D.; Lynn, A.; Chakravarti, A.; Perrin, G.; Antonarakis, S.E. Am. J. Hum. Genet., 1996, 59, (1), 66-75.

48. Klucken, J.; Buchler, C.; Orso, E.; Kaminski, W.E.; Porsch-Ozcurumez, M.; Liebisch, G.; Kapinsky, M.; Diederich, W.; Drobnik, W.; Dean, M.; Allikmets, R.; Schmitz, G. Proc Natl Acad Sci USA, 2000, 97, (2), 817-822.

49. Berge, K.E.; Tian, H.; Graf, G.A.; Yu, L.; Grishin, N.V.; Schultz, J.; Kwiterovich, P.; Shan, B.; Barnes, R.; Hobbs, H.H. Science, 2000, 290 (5497),1771-1775.

50. Shulenin, S.; Schriml, L.M.; Remaley, A.T.; Fojo, S.; Brewer, B.; Allikmets, R.; Dean, M. Cytogenet. Cell Genet., 2001, 92 (3-4), 204-208.

51. Allikmets, R.; Schriml, L.M.; Hutchinson, A.; Romano-Spica, V.; Dean, M. Cancer Res., 1998, 58 (23), 5337-5339.

52. Doyle, L.A.; Yang, W.; Abruzzo, L.V.; Krogmann, T.; Gao, Y.; Rishi, A.K.; Ross, D.D. Proc Natl Acad Sci USA, 1998, 95 (26) 15665-15670.

53. Miyake, H.; Tolcher, A.; Gleave, M.E. Cancer Res., 1999, 59 (16), 4030-4.

54. Loo, T.W.; Clarke, D.M. J. Biol. Chem., 2001, 276 (40), 36877-36880.

55. Higgins, C.F. and Gottesman, M.M. Trends. Biochem. Sci., 1992, 17 (1), 18-21.

56. Qian, Y.M.; Qiu, W.; Gao, M.; Westlake, C.J.; Cole, S.P.; Deeley, R.G. J. Biol. Chem., 2001, 276 (42), 38636-38644.

57. Homolya, L.; Varadi, A.; Sarkadi, B. Biofactors, 2003, 17 (1-4), 103-14.

58. Ambudkar, S.V.; Dey, S.; Hrycyna, C.A.; Ramachandra, M.; Pastan, I.; Gottesman, M.M. Annu Rev Pharmacol Toxicol. 1999, 39, 361-98.

59. Loo, T.W.; Clarke, D.M. J Biol Chem., 2001, 276 (18), 14972-9.

60. Szabó, K.; Welker, E.; Bakos, Á.; Müller, M.; Roninson, I.; Varadi, A.; Sarkadi, B. J. Biol. Chem. 1998, 273 (17), 10132-10138.

61. Hrycyna, C.A.; Ramachandra, M.; Ambudkar, S.V.; Ko, Y.H.; Pedersen, P.L.; Pastan, I.; Gottesman, M.M. J. Biol. Chem., 1998, 273 (27), 16631-16634.

62. Hrycyna, C.A.; Airan, L.E.; Germann, U.A.; Ambudkar, S.V.; Pastan, I.; Gottesman, M.M. Biochemistry, 1998, 37 (39), 13660-13673.

63. Sauna, Z.E.; Ambudkar, S.V. J. Biol. Chem., 2001, 276 (15), 11653-11661.

64. Senior, A.E.; Gadsby, D.C. Semin Cancer Biol. 1997, 8 (3), 143-50.

65. Ozvegy, C.; Varadi, A.; Sarkadi, B. J Biol Chem, 2002, 277 (50), 47980-90.

66. Rao, V.V.; Dahlheimer, J.L.; Bardgett, M.E.; Snyder, A.Z.; Finch, R.A.; Sartorelli, A.C.; Piwnica-Worms, D. Proc. Natl. Acad. Sci., 1999, 96 (7), 3900-3905.

67. Bart, J.; Groen, H.J.; Hendrikse, N.H.; van der Graaf, W.T.; Vaalburg, W.; de Vries, E.G. Cancer Treat. Rev., 2000, 26 (6), 449-462.

68. Bates, S.E.; Robey, R.; Miyake, K.; Rao, K.; Ross, D.D.; Litman, T. J. Bioenerg. Biomembr., 2001, 33 (6) 503-511.

69. Zhou, S.; Schuetz, J.D.; Bunting, K.D.; Colapietro, A.M.; Sampath, J.; Morris, J.J.; Lagutina, I.; Grosveld, G.C.; Osawa, M.; Nakauchi, H.; Sorrentino, B.P. Nat. Med., 2001, 7 (9), 1028-1034.

70. Kipp, H.; Arias, I.M. Semin. Liver Dis., 2000, 20 (3), 339-351.

71. Jonker, J.W.; Smit, J.W.; Brinkhuis, R.F.; Maliepaard, M.; Beijnen, J.H.; Schellens, J.H.; Schinkel, A.H. J. Natl. Cancer Inst., 2000, 92 (20), 1651-1656.

72. Ozvegy, C.; Litman, T.; Szakacs, G.; Nagy, Z.; Bates, S.; Varadi, A.; Sarkadi, B. Biochem Biophys Res Commun., 2001, 285 (1), 111-7.

73. Bodo, A., Bakos, E., Szeri, F., Varadi, A., Sarkadi, B.; J Biol Chem. 2003, 278, (26), 23529-37

74. Zelcer, N.; Huisman, M.T.; Reid, G.; Wielinga, P.; Breedveld, P.; Kuil, A.; Knipscheer, P.; Schellens, J.H.; Schinkel, A.H.; Borst, P. J Biol Chem. 2003, 278, (26), 23538-44. Epub 2003 Apr 17

75. Goldstein, L.J.; Pastan, I.; Gottesman, M.M. Crit Rev Oncol Hematol. 1992, 12 (3), 243-53.

76. Borst, P.; Elferink, R.O. Annu Rev Biochem., 2002, 71, 537-92. Epub 2001 Nov 09.

77. Borst, P.; Kool, M.; Evers, R. Semin Cancer Biol., 1997, 8 (3) 205-13.

78. Borst, P.; Evers, R.; Kool, M.; Wijnholds, J. Biochim Biophys Acta., 1999, 1461 (2) 347-57.

79. Hipfner, D.R.; Deeley, R.G.; Cole, S.P. Biochim Biophys Acta. 1999, 1461 (2), 359-76.

80. Hirohashi, T.; Suzuki, H.; Sugiyama, Y. J Biol Chem., 1999, 274 (21), 15181-5.

81. Litman, T.; Druley, T.E.; Stein, W.D.; Bates, S.E. Cell Mol Life Sci, 2001, 58 (7), 931-59.

82. Lecureur, V.; Courtois, A.; Payen, L.; Verhnet, L.; Guillouzo, A.; Fardel, O. Toxicology., 2000, 153 (1-3), 203-19.

83. Smith, A.J.; van Helvoort, A.; van Meer, G.; Szabo, K.; Welker, E.; Szakacs, G,; Varadi, A.; Sarkadi, B.; Borst, P. J Biol Chem., 2000, 275 (31), 23530-9.

84. List, A.F.; Kopecky, K.J.; Willman, C.L.; Head, D.R.; Persons, D.L.; Slovak, M.L.; Dorr, R.; Karanes, C.; Hynes, H.E.; Doroshow, J.H.; Shurafa, M.; Appelbaum, F.R. Blood, 2001, 98 (12), 3212-20.

85. Krishna, R.; Mayer, L.D. Eur J Pharm Sci., 2000, 11 (4), 265-83.

86. Sharom, F.J.; Yu, X.; Lu, P.; Liu, R.; Chu, J.W.; Szabo, K.; Muller, M.; Hose, C.D.; Monks, A.; Varadi, A.; Seprodi, J.; Sarkadi, B. Biochem Pharmacol. 1999, 58 (4), 571-86.

87. Oram, J.F.; Lawn, R.M. J Lipid Res., 2001, 42 (8), 1173-9.

88. Srivastava, N. Mol Cell Biochem., 2002, 237 (1-2), 155-64.

89. Schmitz, G.; Langmann, T. Curr Opin Lipidol., 2001, 12 (2), 129-40.

90. Oram, J.F. Trends Mol Med., 2002, 8 (4), 168-73.

91. Oram, J.F. Curr Opin Lipidol., 2002, 13 (4), 373-81.

92. Schmitz, G.; Kaminski, W.E.; Front Biosci., 2001, 6, D505-14.

93. Santamarina-Fojo, S.; Remaley, A.T.; Neufeld, E.B.; Brewer, H.B. Jr. J Lipid Res., 2001, 42 (9), 1339-45.

94. Graf, G.A.; Li, W.P.; Gerard, R.D.; Gelissen, I.; White, A.; Cohen, J.C.; Hobbs, H.H. J Clin Invest., 2002, 110 (5), 659-69.

95. Bunting, K.D.; Zhou, S.; Lu, T.; Sorrentino, B.P. Blood., 2000, 96 (3), 902-9.

96. Hafkemeyer, P.; Licht, T.; Pastan, I.; Gottesman, M.M. Hum Gene Ther., 2000, 11, (4), 555-65.

97. Schiedlmeier, B.; Schilz, A.J.; Kuhlcke, K.; Laufs, S.; Baum, C.; Zeller, W.J.; Eckert, H.G.; Fruehauf, S. Hum Gene Ther., 2002, 13 (2), 233-42.

98. Sellers, S.E.; Tisdale, J.F.; Agricola, B.A.; Metzger, M.E.; Donahue, R.E.; Dunbar, C.E.; Sorrentino, B.P. Blood., 2001, 97 (6), 1888-91.

99. Smeets, M.E.; Raymakers, R.A.; Vierwinden, G.; Pennings, A.H.; Wessels, H.; de Witte, T. Blood., 1999, 94 (7), 2414-23.

100. Ross, D.D.; Yang, W.; Abruzzo, L.V.; Dalton, W.S.; Schneider, E.; Lage, H.; Dietel, M.; Greenberger, L.; Cole, S.P.; Doyle, L.A. J Natl Cancer Inst. 1999, 91 (5), 429-33.

101. Litman, T.; Brangi, M.; Hudson, E.; Fetsch, P.; Abati, A.; Ross, D.D.; Miyake, K.; Resau, J.H.; Bates, S.E. J Cell Sci., 2000, 3 ( Pt 11), 2011-21.

102. Bunting, K.D. Stem Cells., 2002, 20 (1), 11-20.

103. Kim, M.; Turnquist, H.; Jackson, J.; Sgagias, M.; Yan, Y.; Gong, M.; Dean, M.; Sharp, J.G.; Cowan, K. Clin Cancer Res, 2002, 8 (1), 22-28.

104. Honjo, Y.; Hrycyna, C.A.; Yan, Q.W.; Medina-Perez, W.Y.; Robey, R.W.; van de Laar, A.; Litman, T.; Dean, M.; Bates, S.E. Cancer Res., 2001, 61 (18), 6635-9.

105. Aungst, B.J.; J Pharm Sci, 1993, 82 (10), 979-987.

106. Kruijtzer, C.M.; Beijnen, J.H.; Schellens, J.H. The Oncologist, 2002, 7 (6), 516-30.

107. Taipalensuu, J.; Tornblom, H.; Lindberg, G.; Einarsson, C.; Sjoqvist, F.; Melhus, H.; Garberg, P.; Sjostrom, B.; Lundgren, B.; Artursson, P. J Pharm Exp Ther, 2001, 299 (1), 164.

108. Sparreboom, A.; van Asperen, J.; Mayer, U.; Schinkel, A.H.; Smit, J.W.; Meijer, D.K.; Borst, P.; Nooijen, W.J.; Beijnen, J.H.; van Tellingen, O. Proc Nat Acad Sci USA, 1997, 94 (5), 2031-5.

109. van Asperen, J.; van Tellingen, O.; Sparreboom, A.; Schinkel, A.H.; Borst, P.; Nooijen, W.J.; Beijnen, J.H. Br J Cancer, 1997, 76 (9), 1181-3.

110. Dietrich, C.G.; de Waart, D.R.; Ottenhoff, R.; Schoots, I.G.; Elferink, R.P. Mol Pharmacol, 2001, 59 (5), 974-80.

111. Lin H.J. and Yamazaki M, Clin Pharmacokinet, 2003, 42, (1), 59-98

112. Sugiyama et al. (1999) J Cont Release 62: 179-186

113. Mahar Doan, K.M.; Humphreys, J.E.; Webster, L.O.; Wring, S.A.; Shampine, L.J.; Serabjit-Singh, C.J.; Adkison, K.K.; Polli, J.W. J Pharm Exp Therapeutics, 2002, 303 (3), 1029-1037.

114. Ghersi-Egea, J.F.; Strazielle, N. Microsc Res Techn, 2001, 52 (1), 83-88.

115. Wijnholds, J.; deLange, E.C.; Scheffer, G.L.; van den Berg, D.J.; Mol, C.A.; van der Valk, M.; Schinkel, A.H.; Scheper, R.J.; Breimer, D.D.; Borst, P. J Clin Invest, 2000, 105 (3), 279-85.

116. Potschka, H.; Fedrowitz, M.; Loscher, W. J Pharmacol Exp Ther, 2003, 306 (1), 124-31.

117. Fricker, G.; Nobmann, S.; Miller, D.S. Br J Pharmacol, 2002, 135 (5), 1308-14.

118. Cooray, H.C.; Blackmore, C.G.; Maskell, L.; Barrand, M.A. Neuroreport, 2002, 13 (16), 2059-63.

119. Lankas, G.R.; Wise, L.D.; Cartwright, M.E.; Pippert, T.; Umbenhauer, D.R. Reprod Toxicol, 1998, 12 (4), 457-463.

120. St-Pierre, M.V.; Serrano, M.A.; Macias, R.I.; Dubs, U.; Hoechli, M.; Lauper, U.; Meier, P.J.; Marin, J.J. Am J Physiol Regul Integr Comp Physiol., 2000, 279 (4), R1495-503.

121. von Richter, O.; Greiner, B.; Fromm, M.F.; Fraser, R.; Omari, T.; Barclay, M.L.; Dent, J.; Somogyi, A.A.; Eichelbaum, M. Clin Pharmacol Ther, 2001, 70 (3), 217-227.

122. Mayer, U.; Wagenaar, E.; Dorobek, B.; Beijnen, J.H.; Borst, P.; Schinkel, A.H. J Clin Invest, 1997, 100 (10), 2430-2436.

123. Hochman, J.H.; Chiba, M.; Yamazaki, M.; Tang, C.; Lin, J.H. J Pharmacol Exp Ther, 2001, 298 (1), 323-330.

124. Lin, J.H.; Chiba, M.; Chen, I.W.; Nishime, J.A.; deLuna, F.A.; Yamazaki, M.; Lin, Y.J. Drug Metab Dispos, 1999, 27 (10), 1187-1193.

125. Kawahara, M.; Sakata, A.; Miyashita, T.; Tamai, I.; Tsuji, A. J Pharm Sci, 1999, 88 (12), 1281-1287.

126. van Asperen, J.; van Tellingen, O.; Tijssen, F.; Schinkel, A.H.; Beijnen, J.H. Br J Cancer, 1999, 79 (1), 108-13.

127. Smit, J.W.; Schinkel, A.H.; Weert, B.; Meijer, D.K. Br J Pharmacol, 1998, 124 (2), 416-424.

128. Stieger, B.; Fattinger, K.; Madon, J.; Kullak-Ublick, G.A.; Meier, P.J. Gastroenterology, 2000, 118 (2), 422-430.

129. Greiner, B.; Eichelbaum, M.; Fritz, P.; Kreichgauer, H.P.; von Richter, O.; Zundler, J.; Kroemer, H.K J Clin Invest, 1999, 104 (2), 147-153.

130. Hamman, M.A.; Bruce, M.A.; Haehner-Daniels, B.D.; Hall, S.D. Clin Pharmacol Ther, 2001, 69 (3), 114-121.

131. Deferme, S.; Van Gelder, J.; Augustijns, P. J Pharm Pharmacol, 2002, 54 (9), 1213-1219.

132. Marques-Santos, L.F.; Bernardo, R.R.; de Paula, E.F.; Rumjanek, V.M. Pharmacol Toxicol, 1999, 84 (3), 125-129.

133. Schinkel, A.H.; Smit, J.J.; van Tellingen, O.; Beijnen, J.H.; Wagenaar, E.; van Deemter, L.; Mol, C.A.; van der Valk, M.A.; Robanus-Maandag, E.C.; te Riele, H.P. et al. Cell, 1994, 77 (4), 491-502.

134. Kala, S.V.; Neely, M.W.; Kala, G.; Prater, C.I.; Atwood, D.W.; Rice, J.S.; Lieberman, M.W. J Biol Chem, 2000, 275 (43), 33404-33408.

135. Scheffer, G.L.; Kool, M.; de Haas, M.; de Vree, J.M.; Pijnenborg, A.C.; Bosman, D.K.; Elferink, R.P.; van der Valk, P.; Borst, P.; Scheper, R.J. Lab Invest, 2002, 82 (2), 193-201.

136. Hirohashi, T.; Suzuki, H.; Ito, K.; Ogawa, K.; Kume, K.; Shimizu, T.; Sugiyama, Y. Mol Pharmacol, 1998, 53 (6), 1068-1075.

137. Fattinger, K.; Funk, C.; Pantze, M.; Weber, C.; Reichen, J.; Stieger, B.; Meier, P.J. Clin Pharmacol Ther, 2001, 69 (4), 223-231.

138. Funk, C.; Ponelle, C.; Scheuermann, G.; Pantze, M. Mol Pharmacol, 2001, 59 (3), 627-635.

139. Zhang, Y.; Bachmeier, C.; Miller, D.W. Adv Drug Deliv Rev, 2003, 55 (1), 31-51.

140. Zeng, H.; Liu, G.; Rea, P.A.; Kruh, G.D.; Cancer Res. 2000, 60 (17), 4779-84.

141. Sarkadi, B.; Price, E.M.; Boucher, R.C.; Germann, U.A.; Scarborough, G.A. J Biol Chem. 1992, 267 (7), 4854-8.

142. Breuninger, L.M.; Paul, S.; Gaughan, K.; Miki, T.; Chan, A.; Aaronson, S.A.; Kruh, G.D. Cancer Res, 1995, 55 (22), 5342-7.

143. Reid, G.; Wielinga, P.; Zelcer, N.; De Haas, M.; Van Deemter, L.; Wijnholds, J.; Balzarini, J.; Borst, P. Mol Pharmacol. 2003, 63 (5), 1094-103.

144. Feller, N.; Kuiper, C.M.; Lankelma, J.; Ruhdal, J.K.; Scheper, R.J.; Pinedo, H.M.; Broxterman, H.J. Br J Cancer, 1995, 72 (3), 543-9. Erratum in: Br J Cancer 1996, 74, 2042.

145. Weaver, J.L.; Pine, P.S.; Aszalos, A.; Schoenlein, P.V.; Currier, S.J.; Padmanabhan, R.; Gottesman, M.M. Exp Cell Res 1991, 196 (2), 323-329.

146. Lee, J.S.; Paull, K.; Alvarez, M.; Hose, C.; Monks, A.; Grever, M.; Fojo, A.T.; Bates, S.E. Mol Pharmacol 1994, 46 (4), 627-638.

147. Chaudhury, P.M. and Roninson, I.B. Cell, 1991, 66 (1), 85-94.

148. Homolya, L.; Hollo, Z.; Germann, U.A.; Pastan, I.; Gottesman, M.M.; Sarkadi, B. J Biol Chem. 1993, 268 (29), 21493-6.

149. Haugland, R.P. and Larison, K.D. In Handbook of Fluorescent Probes and Research Chemicals, Molecular Probes, Eugene, OR, 1992-94, pp 163, 172-173

150. Hollo, Z.; Homolya, L.; Hegedus, T.; Sarkadi, B. FEBS Lett 1996, 383 (1-2), 99-104.

151. Karaszi, E.; Jakab, K.; Homolya, L.; Szakacs, G.; Hollo, Z.; Telek, B.; Kiss, A.; Rejto, L.; Nahajevszky, S.; Sarkadi, B.; Kappelmayer, J. Br J Hematol 2001, 112 (2), 308-314.

152. Gaillard, P.J.; van der Sandt, I.C.; Voorwinden, L.H.; Vu, D.; Nielsen, J.L.; de Boer, A.G.; Breimer, D.D. Pharm Res, 2000, 17 (10), 1198-1205.

153. Adachi, Y.; Suzuki, H.; Sugiyama, Y. Pharm. Res, 2001, 18 (12), 1660-1668.

154. Sukhai, M. and Piquette-Miller, M. J Pharm Pharmaceut Sci, 2000<, 3 (2), 268-280.

155. Mechetner, E.B.; Roninson, I.B. Proc Nat Acad Sci USA, 1992, 89 (13), 5824-8.

156. Mechetner, E.B.; Schott, B.; Morse, B.S.; Stein, W.D.; Druley, T.; Davis, K.A.; Tsuruo, T.; Roninson, I.B. Proc Nat Acad Sci USA, 1997, 94 (24), 12908-13.

157. Nagy, H.; Goda, K.; Arceci, R.; Cianfriglia, M.; Mechetner, E.; Szabo, G. Jr. Eur J Biochem, 2001, 268 (8), 2416-20.

158. Tabas, L.B. and Dantzig, A.H. Anal Biochem, 2002, 310 (1), 61-66.

159. Bakos Á., Evers R., Sinkó E., Váradi A., Borst P., Sarkadi B.: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol, 2000; 57:760-768

160. Holló Zs., Homolya L., Davis C.W., Sarkadi B.: Calcein accumulation as a fluorometric functional assay of the multidrug transporter. Biochim Biophys Acta 1994; 1191: 384-388

161. Homolya L., Holló Z., Müller M., Mechetner E.B., Sarkadi B.: A new method for quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells. Br J Cancer 1996; 73: 849-855

162. Sarkadi B., Muller M., Homolya L. Hollo Zs., Seprodi J., Germann U.A., Gottesman M.M., Price E.M., Boucher R.C.: Interaction of bioactive hydrophobic peptides with the human multidrug transporter. FASEB J. 1994, 8: 766-770

163. Szabo K., Welker E., Bakos E., Muller M., Roninson I., Varadi A., Sarkadi B.: Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains. J Biol Chem 1998; 273: 10132-10138

164. Taguchi Y., Yoshida A., Takada Y., Komano T., Ueda K.: Anti-cancer drugs and glutathione stimulate vanadate-induced trapping of nucleotide in multidrug resistance-associated protein (MRP). FEBS Lett. 1997; 401: 11-14

165. BodÁ A., Bakos Á., Szeri F., Váradi A., Sarkadi B.: The role of multidrug transporters in drug availability, metabolism and toxicity. Toxicology Letters Toxicol Lett. 2003 Apr 11;140-141:133-43.

166. Madon J, Eckhardt U, Gerloff T, Stieger B, Meier PJ.: Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett. 1997 Apr 7;406(1-2):75-8.

167. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, Meier PJ.: The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem. 1998 Apr 17;273(16):10046-50

168. Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ.: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58.

169. NoÁ J, Stieger B, Meier PJ.: Functional expression of the canalicular bile salt export pump of human liver. Gastroenterology. 2002 Nov;123(5):1659-66.

170. Funk C, Pantze M, Jehle L, Ponelle C, Scheuermann G, Lazendic M, Gasser R.: Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate. Toxicology. 2001 Oct 5;167(1):83-98.

171. Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ.: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30.

172. Kullak-Ublick GA, Stieger B, Meier PJ.: Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322-42

173. Faber KN, Muller M, Jansen PL.: Drug transport proteins in the liver. Adv Drug Deliv Rev. 2003 Jan 21;55(1):107-24.

174. Kaplowitz N, DeLeve LD, Drug-induced liver disease. Eds Part II: Jansen Peter LM, Müller M.: The role of membrane transport in drug-induced hepatotoxicity and cholestasis; Marcel Dekker. 2003

175. Cserepes J, Szentpetery Z, Seres L, Ozvegy-Laczka C, Langmann T, Schmitz G, Glavinas H, Klein I, Homolya L, Varadi A, Sarkadi B, Elkind NB.: Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. Biochem Biophys Res Commun. 2004 Jul 30;320(3):860-7.

176. Van Aubel RA, Smeets PH, van den Heuvel JJ, and Russel FG. Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am J Physiol Renal Physiol 288: F327-F333, 2004

177. Van Aubel RA, Smeets PH, van den Heuvel JJ, Russel FG. Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am J Physiol Renal Physiol. 2005 Feb;288(2):F327-33. Epub 2004 Sep 28. PMID: 15454390 [PubMed - indexed for MEDLINE]

178. Homolya L, Varadi A, Sarkadi B. Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate. Biofactors. 2003;17(1-4):103-14. Review. PMID: 12897433 [PubMed - indexed for MEDLINE]

179. Van Aubel RA, Smeets PH, Peters JG, Bindels RJ, and Russel FG. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol 13: 595-603, 2002