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Catalog > Services > Uptake Transporter Services > Uptake Transporter Assays

Uptake Transporter Assays

Service	Transporter	Technology	Probe Substrate	Reference Inhibitor	Barrier
ASBT Uptake Transporter Assay	ASBT	Uptake Transporter Assay	Taurocholic acid	Fluvastatin	Intestinal Barrier Renal Barrier
HPT1 Uptake Transporter Assay	HPT1	Uptake Transporter Assay	Gly-Sar	Cefadroxil	Intestinal Barrier
MATE1 Uptake Transporter Assay	MATE1	Uptake Transporter Assay	Tetraethylammonium-chloride (TEA), Metformin	Quinidine	Renal Barrier Hepatic Barrier
MATE2-K Uptake Transporter Assay	MATE2-K	Uptake Transporter Assay	Tetraethylammonium-chloride (TEA), Metformin	Pyrimethamine	Renal Barrier
NTCP Uptake Transporter Assay	NTCP	Uptake Transporter Assay	Taurocholate	TCDC	Hepatic Barrier
Ntcp - Rat Uptake Transporter Assay	Ntcp - rat	Uptake Transporter Assay	Taurocholate	TCDC	Hepatic Barrier
OAT1 Uptake Transporter Assay	OAT1	Uptake Transporter Assay	p-Aminohippuric acid (PAH), Tenofovir	Benzbromarone, Probenecid	Renal Barrier
Oat1 - rat Uptake Transporter Assay	Oat1 - rat	Uptake Transporter Assay	p-Aminohippuric acid (PAH)	Benzbromarone	Renal Barrier
OAT3 Uptake Transporter Assay	OAT3	Uptake Transporter Assay	Estrone-3-Sulfate (E3S), Methotrexate	Probenecid	Renal Barrier
Oatp1a1 - Rat Uptake Transporter Assay	Oatp1a1 - rat	Uptake Transporter Assay	Estrone-3-Sulfate (E3S)	Ketoconazole	Blood-brain-barrier
OATP1A2 Uptake Transporter Assay*	OATP1A2	Uptake Transporter Assay	Estrone-3-Sulfate (E3S)	Fexofenadine	Hepatic Barrier Blood-brain-barrier Intestinal Barrier Renal Barrier
OATP2A1 Uptake Transporter Assay	OATP2A1	Uptake Transporter Assay	Prostaglandin-E2	Diclofenac	Renal Barrier
OATP1B1 Uptake Transporter Assay	OATP1B1	Uptake Transporter Assay	Estrone-3-Sulfate (E3S)	Cerivastatin	Hepatic Barrier
OATP1B3 Uptake Transporter Assay	OATP1B3	Uptake Transporter Assay	Fluo-3	Fluvastatin	Hepatic Barrier
OATP2B1 Uptake Transporter Assay	OATP2B1	Uptake Transporter Assay	Estrone-3-Sulfate (E3S)	Fluvastatin	Hepatic Barrier Intestinal Barrier Renal Barrier
OCT1 Uptake Transporter Assay	OCT1	Uptake Transporter Assay	Tetraethylammonium-chloride (TEA), Metformin, MPP+	Verapamil	Hepatic Barrier Intestinal Barrier
OCT2 Uptake Transporter Assay	OCT2	Uptake Transporter Assay	Tetraethylammonium-chloride (TEA), Metformin, MPP+	Verapamil, Quinine	Renal Barrier
OCT3 Uptake Transporter Assay*	OCT3	Uptake Transporter Assay	Tetraethylammonium-chloride (TEA)	b-estradiol	Hepatic Barrier Renal Barrier
OCTN1 Uptake Transporter Assay	OCTN1	Uptake Transporter Assay	Tetraethylammonium-chloride (TEA)	Verapamil	Renal Barrier
OCTN2 Uptake Transporter Assay	OCTN2	Uptake Transporter Assay	Carnitine	Verapamil	Renal Barrier
Octn2-rat Uptake Transporter Assay	Octn2-rat	Uptake Transporter Assay	Carnitine	Verapamil	Renal Barrier Blood-brain-barrier
PEPT1 Uptake Transporter Assay	PEPT1	Uptake Transporter Assay	Gly-Sar	Tyr-Phe	Intestinal Barrier
PEPT2 Uptake Transporter Assay	PEPT2	Uptake Transporter Assay	Gly-Sar	Cefadroxil	Renal Barrier Blood-brain-barrier
SGLT1 Uptake Transporter Assay	SGLT1	Uptake Transporter Assay	methyl-a-D-glucopyranoside	Phloridzin	Intestinal Barrier Renal Barrier
URAT1 Uptake Transporter Assay	URAT1	Uptake Transporter Assay	Uric acid, Orotic acid	Benzbromarone	Renal Barrier

Description

SOLVO provides two types of uptake transporter studies: inhibition assessment, and substrate assessment. Both are suitable for drug-drug interaction studies: the indirect assays use predefined uptake transporter substrates for this purpose, while the direct assays can be designed to test the drug-drug interaction of the client’s test article with any potential perpetrator compound.

*OATP1A2 and OCT3 uptake transporter assays are currently available on HEK 293 cells transiently transfected with OATP1A2 or OCT3, respectively.

Unique services at SOLVO: OCT1, OCT2, and MATE2-K inhibition assessment assays are available for alternative probe substrates; TEA and Metformin as well.

Learn more about our uptake transporter assay services.

Learn more about our uptake transporter assay technology.