As a pioneer in the drug transporter field for 20 years, SOLVO is dedicated to exploring the science of transporters and their role in xenobiotic efficacy and safety. With frequent Webinars hosted by respected scholars and professionals, as well as numerous peer-reviewed publications, our commitment and scientific contribution to the transporter field is well recognized.
After the great success of our events in SOLVO’s Meet the Experts: Transporter Conference series, we are pleased to announce that the ninth event will be held in Boston on September 3-5, 2019. With the Meet the Experts: Transporter Conference series, we took our commitment to the transporter field to a new level. The sessions will focusing on the most relevant and up-to-date aspects of transporter science and industry applications.
Venue: Boston Marriott Cambridge, 50 Broadway, Cambridge, MA 02142, US
Thank you for sponsoring:
Call for Abstract:
SOLVO invites all attendees to submit poster abstracts for this meeting. Moreover, we will select 2 abstracts for short oral poster presentations during the plenary session of the conference. Once registered for the conference, submit your abstract to email@example.com by Friday, August 9, 2019.
Free Registrations Available for Academic Researchers:
A limited number of FREE REGISTRATIONS are available for attendees from academic institutions who have submitted a poster abstract. To apply, submit your abstract to firstname.lastname@example.org by Friday 9th August, 2019.
2-day conference registration fees:
Early bird registration fee until 4 July 2019: $250
Standard registration fee after 4 July 2019: $350
One-day pre-conference Workshop on 3 September: $50
Early bird registration fee for Academic researchers: $200
Standard registration fee for Academic researchers: $300
Payment can be made by wire-transfer or credit card. Please click here for credit card authorization form.
Cancellation policy: “Refunds will be issued for all requests received in writing by 4 July 2019. Refunds will not be issued for requests received after 4 July 2019.” Send cancellation request to email@example.com.
Your registration fee covers besides the conference program, lunchbox, coffee breaks, reception.
|9:00-||Registration and coffee|
|10:20-||Intro||Péter Krajcsi, PhD, SOLVO Biotechnology|
|Session 1: Oral exposure, DDI|
|10:40-||Variability In Oral Exposure and Formulation Strategies||Laurent Salphati, PhD, Genentech|
|11:10-||The Gut-Brain-Microbiome Axis: Epacadostat Transport and Metabolism on Brain Serotonin Concentration||Yan Zhang, PhD, Incyte Corporation|
|11:40-||Selection of an Optimal In Vitro Assay and Clinical Probe Substrate to Assess P-gp Inhibition: Challenges and Path Forward||Xiaoyan Chu, PhD, Merck|
|Session 2: Hepatic, Renal DDI and Toxicity|
|13:10-||Keynote: ADME Biomarkers of Drug-drug Interaction||David Rodrigues, PhD, Pfizer|
|13:50-||Emerging In Vitro Kidney Models to Study Drug Elimination and Nephrotoxicity||Piyush Bajaj, PhD, Takeda Pharmaceuticals|
|14:20-||In-vitro and In-vivo Models to Study Drug Inflicted Changes on Bile Acids/Salt Homeostasis||Yutai Li, PhD, Merck|
|Session 3: CNS Disposition|
|15:20-||Blood-Brain Barrier Transporters in Ischemic Stroke: Focus on Oatps||Patrick T. Ronaldson, PhD, University of Arizona|
|15:50-||Organoid Platform for Modeling the Blood-brain-barrier||Choi-Fong Cho, PhD, MIT, Broad Institure of Harvard|
|16:20-||Translating Transporter Activity into Quantitative Brain Penetration Predictions||Jennifer Liras, PhD, Pfizer|
|17:00-||Reception with poster session|
|Session 4: Protein Binding, Metabolism and Transport|
|8:30-||Keynote: Transporter-Enzyme Interplay in Hepatic Clearance…More Common than We Think||Manthena V. Varma, PhD, Pfizer|
|9:10-||Metabolism and Transporter-based Drug-drug Interactions In Recent New Drug Applications: Mechanistic Understanding and Clinical Relevance||Isabelle Ragueneau-Majlessi, MD, MS, University of Washington|
|9:40-||Protein Binding Methodologies and Relevance for DDI - an Industry Perspective||Li Di, PhD, Pfizer|
|Session 5: Physiology, pathophysiology and therapy|
|10:40-||Heme /Porhyrin Metabolism and Transport||John Schuetz, PhD, St. Jude Children's Research Hospital|
|11:10-||Structure-based Ligand Discovery for Human Nutrient Transporters||Avner Schlessinger, PhD, Icahn School of Medicine at Mount Sinai|
|11:40-||Improvement of Nanoparticle Drug Delivery by Surface Conjugation with L-carnitine: Role of OCTN2/SLC22A5 and ATB0,+ (SLC6A14)||Vadivel Ganapathy, PhD, Texas Tech University|
|Session 6: Methods and Models|
|13:10-||Utilizing DILIsym, a QST Platform, to Extract More from Your Data to Support Decisions||Brett A. Howell, PhD, DILIsym|
|14:10-||Closing Remarks||Péter Krajcsi, PhD, SOLVO Biotechnology|
*We reserve the right to change the Agenda.
In addition to the main conference, SOLVO will be hosting a Workshop on Tuesday, September 3 in which SOLVO scientists will provide training on the theory and practice of studying drug transporters in the lab, including in vitro methods for staying transporters, transporter study design, bioanalytics, transporter data evaluation and interpretation, and timing and application of transporter studies in drug development. Please note that this event is an optional add-on for attendees who have registered for the Transporter Conference.
Scientist II, Investigative Toxicology, Drug Safety Research and Evaluation, Takeda Pharmaceuticals, Cambridge, MA
Piyush Bajaj got his PhD from the University of Illinois Urbana Champaign. Dr. Bajaj then did a postdoc at Los Alamos national lab (LANL) developing organs-on-a-chip which could be used for both efficacy and safety assessment. After his postdoc at LANL, Dr. Bajaj moved to Pfizer where he developed/validated protocols for generating human pluripotent stem cell-derived three-dimensional (3D) kidney organoids and was involved in de-risking of potential target organ toxicities using physiologically relevant in vitro models. Dr. Bajaj is now a part of Takeda’s investigative toxicology group where he co-leads liver and kidney de-risking strategies which are applied for proactive management of potential safety liabilities of compounds in the discovery stages.
Affiliate in Dept. of Chemistry, Massachusetts Institute of Technology; Associated Scientist | Broad Institute of Harvard and MIT, Boston, MA
Choi-Fong Cho, PhD is an Instructor in the Department of Neurosurgery at the Brigham and Women’s Hospital (BWH), Harvard Medical School. She is an Affiliate at the Massachusetts Institute of Technology (MIT), and an Associated Scientist at the Broad Institute of Harvard and MIT. She received her PhD in Medical Biophysics at Western University in Canada, which was fully supported by multiple national and provincial scholarships. She later completed her post-doctoral fellowship in Neuro-oncology at BWH, where her fellowship was fully funded by the Canadian Institute of Health Research. She was promoted to become a junior faculty member within the Neurosurgery Department in 2017 to initiate her own laboratory. The Cho group at BWH has pioneered an organoid platform to model the blood-brain-barrier in culture for high-throughput screening and analysis of brain-penetrant drugs. They continue to employ this technology for designing novel anti-brain cancer drugs with improved tumor-specificity and delivery into the brain.
Senior Principle Scientist Merck &Co. Rahway, NJ, USA
Dr. Xiaoyan Chu is a Senior Principle Scientist in the Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM), Merck & Co., Inc., Rahway, NJ. She received her Ph.D. from the Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan. After completing her post-doctoral research at the Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, she joined the Department of PPDM at Merck & Co., Inc. As the scientific leader for the Transporter & In Vitro Technology Group, her main responsibilities are to develop transporter strategies to support Merck discovery and development portfolio, and to evaluate and establish new technologies to study the role of drug transporters in drug disposition and drug-drug interactions. She has authored 70 peer-reviewed research papers, book chapters, and is an invited speaker at over 30 national/international scientific conferences. She is a member of the International Transport Consortium (ITC) and serves as organizer and steering committee member of various scientific meetings/organizations.
Research Fellow, Pharmacokinetics, Dynamics Metabolism Department, Pfizer, Groton, CT
Dr. Li Di has over 20 years of experience in the pharmaceutical industry including Pfizer, Wyeth and Syntex. She is currently a research fellow at Pfizer, Groton, CT. Her research interests include the areas of drug metabolism, pharmacokinetics, drug-drug interactions, absorption, transporters, and blood–brain barrier. She has over 140publications including two books and presented over 80 invited lectures. She is a recipient of the Thomas Alva Edison Patent Award, the New Jersey Association for Biomedical Research Outstanding Woman in Science Award, the Wyeth President’s Award and Peer Award for Excellence.
Grover Murray Professor & the Chair, & the Welch Endowed Chair in Biochemistry in the Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX
Dr. Vadivel Ganapathy received his Ph. D. in biochemistry from the University of Madras, India in 1978. He joined the Medical College of Georgia, Augusta, GA in the United States in 1979 for his post-doctoral training. He has cloned and characterized more than 40 mammalian transporters; these transporters mediate the cellular uptake of amino acids, vitamins, monocarboxylates, citric acid cycle intermediates, carnitine, and drugs. He has published 485 full-length papers and 30 reviews/book chapters. His Google Scholar citation h-index is 96. In recognition of his contributions to the field of nutrient transporters, he was awarded the Rank Prize for Nutrition in 2004, which he shared with two other scientists. To date, he has trained 13 Ph. D. students and mentored more than 15 post-doctoral fellows. His current lab consists of 5 graduate students (2 PhD. and 3 MD/PhD) and 4 post-doctoral fellows. Presently, he is a Grover Murray Professor and the Chair and also the Welch Endowed Chair in Biochemistry in the Department of Cell Biology and Biochemistry at the Texas Tech University Health Sciences Center, Lubbock, TX, USA. His research areas include colitis, colon cancer, breast cancer, host-microbiome interaction, iron homeostasis, G-protein-coupled receptors for metabolites, obesity, and Alzheimer’s disease. He holds several patents related to therapeutic strategies for inflammatory bowel disease and cancer. He also teaches medical students various aspects of biochemistry and physiology, and has received numerous awards and recognition for outstanding teaching and innovation in education.
President of DILIsym Services, a Simulations Plus company, Research Tringle Park, NC, US
Brett A. Howell is the President of DILIsym Services, a Simulations Plus company developing and using DILIsym and other software tools to improve the development of safer and more effective drug therapies. He is also an associate director of the DILI-sim Initiative since its inception in 2011. In addition to overseeing DILIsym Services operations, Dr. Howell also helps guide the architecture and use of the DILIsym modeling software. Dr. Howell has published over 30 scientific papers in the areas of PBPK/PD modeling, in vitro toxicity testing, novel drug delivery systems, and drug safety. He has given invited scientific presentations at numerous national and international meetings, including the Society of Toxicology annual meeting, the Japanese Society of Toxicology annual meeting, the annual FDA/AASLD Drug-Induced Liver Injury meeting, the American Conference on Pharmacometrics (ACOP) annual meeting, the European Microsomes and Drug Oxidations annual meeting, and the Drug Information Association (DIA) annual safety meeting. He serves on the editorial board for the prominent Quantitative Systems Pharmacology (QSP) journal, “CPT: Pharmacometrics & Systems Pharmacology,” published by the American Society for Clinical Pharmacology and Therapeutics. Dr. Howell holds a Ph.D. in chemical engineering from the University of Florida and Bachelor of Science degrees in chemical engineering and textile engineering from North Carolina State University.
Chief Scientific Officer, SOLVO Biotechnology Budaors, Hungary
Dr. Peter Krajcsi has extensive experience in biotechnology. He received his PhD in biochemistry from University of Szeged and later a Doctor of Sciences degree in biological sciences from the Hungarian Academy of Sciences. In his academic career he has focused on three major topics (i) steroid receptors (ii) molecular biology of adenoviruses and (iii) apoptosis. For the past 13 years he has been working in R&D management positions for small and medium size enterprises in drug research and gene therapy in Hungary as well as in the United States. Since 2002 he is the Chief Scientific Officer of Solvo Biotechnology. At Solvo the focus is on membrane transporters and utilization of membrane transporter technology in drug discovery and development as well as in development of diagnostics tools for cancer and inflammatory diseases.
Principal Scientist, Pharmaceuticals, Merck, West Point, PA
Yutai Li obtained her BS in 1986 from Liaoning University, China and Ph.D. in 1995 from North Carolina State University. She worked at DuPont, Schering Plough, and University of North Carolina at Chapel Hill before she joined the proteomics and metabolomics group in Merck & Co. in 2004. She currently works on toxicity biomarker discovery using LC-MS based metabolomics approach. Also, she has been working on drug induced liver injury due to transporter inhibition using rodent models.
Vice President Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Inc. Cambridge, MA
Dr. Jennifer Liras is the Pharmacokinetics, Dynamics, and Metabolism Portfolio Lead at Pfizer, Inc. She has more than 20 years of experience leading scientists responsible for characterizing and optimizing the pharmacokinetic properties of large and small molecule drugs. She has a successful record of drug discovery and development across the portfolio in Cardiovascular Metabolic and Endocrine Diseases (CVMED), Antibacterials, Inflammation and Immunology, Neuroscience, Oncology and Rare Disease therapeutic areas. She has dedicated her career to advancing predictive ADME sciences and most recently in tissue targeting, where she was instrumental in the development of predictive capabilities in brain penetration of efflux substrates. Jenny received a Ph.D. in organic chemistry in 1995 from The University of Texas at Austin and conducted her postdoctoral research in enzymology at Brandeis University.
Clinical Professor, Director, Drug Interaction Database (DIDB) Program, Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA
Dr. Ragueneau is a Clinical Professor in the Department of Pharmaceutics, School of Pharmacy, at the University of Washington (UW) and the Director of the Drug Interaction Database program. She received her medical degree from St Antoine University in Paris, France, and specialized in Clinical Pharmacology. Prior to moving to the US, Dr. Ragueneau designed and supervised clinical studies in the private sector and in academia for over 6 years. She started working at the UW in 1999, as a Research Associate, then Principal Research Scientist and Project Manager for the Drug Interaction Database. In November 2009, Dr. Ragueneau joined the faculty of the Department of Pharmaceutics as Clinical Associate Professor and was promoted to full Professor in 2014. Dr. Ragueneau has published in the areas of drug-drug interactions (DDIs), drug disposition and clinical pharmacology. She is interested in the regulatory framework of DDI assessment and the clinical relevance of drug interactions. Dr. Ragueneau graduated from the UW’s Master’s Degree Program in Biomedical Regulatory Affairs in 2010. In 2015, she was named a UW CoMotion Presidential Innovation Fellow.
Senior Scientific Director, Head of the Transporter Sciences Group, Pfizer (ADME Sciences, Medicine Design) Groton, CT
Dr. Rodrigues has been in the pharmaceutical industry for 29 years and now serves as Senior Scientific Director, head of the Transporter Sciences Group, at Pfizer (ADME Sciences, Medicine Design, Groton, CT). Before joining Pfizer, he worked at Bristol-Myers Squibb, Merck, Abbott, and Searle (serving on both scientific and managerial ladders). He has authored nearly 20 book chapters, over 150 peer-reviewed manuscripts, and has presented at over 70 symposia/meetings. Dr. Rodrigues was inducted as AAPS Fellow in 2009 (American Association of Pharmaceutical Scientists). At various times, he has served on the Editorial Board of drug metabolism journals (e.g., Current Drug Metabolism, Drug Metabolism Letters, Xenobiotica, Drug Metabolism & Disposition), is a member of the International Transporter Consortium (ITC), and has edited/co-edited 4 books (3 related to drug interactions and one on the topic of drug metabolism). Presently, Dr. Rodrigues also serves as adjunct professor at the School of Pharmacy, University of Rhode Island.
Associate Professor, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ
Dr. Patrick Ronaldson is an Associate Professor of Pharmacology in the College of Medicine at the University of Arizona in Tucson. Dr. Ronaldson’s research is focused on studying blood-brain barrier (BBB) physiology and pharmacology with an emphasis on the challenges of effectively delivering drugs to the brain in disease states. His research continues to develop “state of the art” methods/procedures/tools/models for the in vivo examination of BBB/neurovascular unit (NVU) integrity, regulation of endothelial “barrier” properties at the molecular level, and how pharmacology of drug transport proteins is altered by stroke, neurodegenerative diseases or acute/chronic pain. Dr. Ronaldson has over 40 peer-reviewed publications and 5 book chapters on BBB physiology and transporter pharmacology. Additionally, he is the past chair of the Drug Transporter Community of the American Association of Pharmaceutical Scientists (AAPS), the chair-elect of the Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) Community of AAPS, and the chair of the Drug Discovery for the Nervous System (DDNS) Study Section of the National Institutes of Health.
Principal Scientist Drug Metabolism and Pharmacokinetics Genentech San Francisco, CA, USA
Dr. Laurent Salphati is currently a Principal Scientist in the Drug Metabolism and Pharmacokinetics department at
Genentech, Inc. He heads the Permeability/Drug Transporters group and has been supporting and leading immunology
and oncology project teams from preclinical discovery to late stage clinical development. He received his Pharm.D.
from the University of Paris XI, France, and conducted his Ph.D research, investigating the complementary roles of
P-glycoprotein and CYP3A in drug absorption and disposition, at the University of California, San Francisco under
the guidance of Dr. Leslie Z. Benet. His research interests include the pharmacokinetics and pharmacodynamics of
drugs (PK/PD and PB/PK modeling) and the roles of drug transporters in drug absorption and disposition.
Assistant Professor, Department of Pharmacological Sciences, Associate Director, Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY
Dr. Avner Schlessinger is an Assistant Professor of Pharmacological Sciences at the Icahn School of Medicine at Mount Sinai in New York City, an Associate Director of Mt. Sinai Center for Therapeutics Discovery, and Co-Director of the Pharmacology, Discovery and Therapeutics Training Area. The overall goal of Dr. Schlessinger’s lab is to improve and automate the structure-based drug discovery process by developing and applying computational methods, and to characterize disease pathways, with a long-term goal of developing drugs against novel targets. His lab publishes in the areas of chemical biology, bioinformatics, and drug discovery, as well as in personalized medicine and pharmacogenomics.
Dr. Schlessinger graduated from Tel Aviv University with a BSc in Biology and Chemistry, and completed his PhD from Columbia University in the Department of Biochemistry and Molecular Biophysics. As a PhD student, he developed programs predicting protein structure and function using various machine-learning approaches such as artificial neural networks. Following his graduate studies, Dr. Schlessinger was an NIH NRSA postdoctoral fellow at the Department of Bioengineering and Therapeutic Sciences at UCSF, where he established methods for structure-based drug design and used these approaches to rationally design tool compounds for membrane proteins and protein kinases. Dr. Schlessinger serves on the editorial boards of PLOS Computational Biology and Journal of General Physiology. He is also an Advisory Board Member of the ReSolute Transporter Consortium as well as a Member of the International Transporter Consortium.
Vice Chair of the Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN, USA
John D. Schuetz received his Ph.D. in Biochemical Pharmacology/Toxicology (with Robert B. Diasio) from the Medical College of Virginia in Richmond in 1984 and completed his postdoctoral training in Molecular Cancer Biology (with I. David Goldman and Eric H. Westin (a Dr. Robert C. Gallo protégé), and subsequently worked with Dr. Philip Guzelian on CYPs, also at the Medical College of Virginia. In 1992, he joined the Pharmaceutical Sciences Department at St. Jude Children’s Research Hospital as an Assistant Member. He was promoted to the rank of Associate Member in 1997 and then to Member in 2005. In 2006, he was appointed Vice Chair of the department and currently holds this position. He has broad research interests in the role of ABC transporters in normal physiology and pathophysiology. His lab’s current studies are elucidating how transporters affect the biology as well as the therapeutic response of medulloblastoma and acute myeloid leukemia. Dr. Schuetz has authored over 154 articles in peer-reviewed journals and contributed several book chapters. Dr. Schuetz has been elected to the AAAS Electorate nominating committee, elected Chair of the Toxicology Division of American Society for Pharmacology and Experimental Therapeutics (ASPET), Councilor to ASPET and is currently serving as Past-President of ASPET. Further, he was nominated to membership in the ASBMB. He has also been a permanent member of the NIH DMP study section (2002-2007) and contributed service as an Ad hoc member on multiple other national and international grant review panels. Moreover, he is an Associate Editor for the journal Drug Metabolism and Disposition and serves on the editorial board of other peer-reviewed journals (e.g., Scientific Reports, The FASEB Journal).
Senior Principal Scientist, Department of Pharmacokinetics, Dynamics and Drug Metabolism, Pfizer Inc. Groton, CT, USA
Dr. Manthena Varma, PhD is Associate Research Fellow, at Pfizer Inc. Dr. Varma received his B. Pharm. degree from the Kakatiya University, India in 2000, and an M.S. degree (2002) and PhD in Pharmaceutics (2005), from the National Institute of Pharmaceutical Education and research (NIPER), Punjab, India. Later, Dr. Varma worked as a Post Doctoral Fellow at the Department of Pharmaceutics, University of Minnesota (Minneapolis). In 2008, he joined Worldwide R&D, Pfizer, Groton, CT. Dr. Varma holds an Adjunct faculty position in the Department of Pharmacy of the University of Rhode Island. Manthena is a founding member and Instructor for a three-day Annual workshop on “Transporters in Drug Discovery and Development: Driving Knowledge from Laboratory to Label” at University of Rhode Island. He is member and ex-chair (2017-18) of North Jersey Drug Metabolism Discussion Group. His research is focused in the fields of ADME/PK technologies and strategies in drug design and development, role of drug transporters and transporter-enzyme interplay (extended clearance) in ADME/PK, clinical pharmacokinetics and DDI predictions/evaluation via mechanistic (PBPK) modeling. He published over 110 original articles/reviews/book chapters and presented over 60 presentations at the scientific conferences in these scientific areas.
Associate Director, Drug Metabolism Pharmacokinetics & Clinical Pharmacology, Incyte Corporation, Wilmington, US
Yan Zhang, PhD, is an Associate Director in the Department of Drug Metabolism, Pharmacokinetics & Clinical Pharmacology (DMPK/CP) at Incyte Corporation in Wilmington, Delaware. She received her M.Sc. degree from the Pharmacology Department at South Dakota State University and her PhD from the Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center. She has fifteen years’ experiences in oncology drug discovery and more than twenty years’ experience in the field of drug transporters. Dr. Zhang is the author of over 40 peer-reviewed publications, book chapters, and abstracts. She serves on the committees of the CPLG Transporter Working Group of the IQ Consortium and the Delaware Valley Drug Metabolism Discussion Group (DVDMDG). She is currently leading the drug absorption, transporter, and drug-drug interactions (DDI) strategies to support Incyte discovery and development programs. Research interests include the pharmacokinetics and pharmacodynamics, clinical pharmacology, and transporter mediated toxicity and DDI.
Conference will be organized at Boston Marriott Cambridge. Boston Marriott Cambridge welcomes you to the city's thriving downtown district with 4-star sophistication and exceptional service. The hotel is ideally situated in the vibrant Kendall Square neighborhood, just a short distance from landmarks including Massachusetts Institute of Technology (MIT) and Harvard University; downtown Boston is only moments away.
Boston Marriott Cambridge offers rooms on discounted prices for the Meet the Experts Transporter Conference – Boston/Cambridge 2019 participants till the August 12, subject to availability. After August 12 rooms can be booked on full price if available.
Room rate: 249 USD/night
Start date: Monday, September 2, 2019
End date: Friday, September 6, 2019
Please note that the price doesn't include the taxes & fees.
Reserve your room by contacting Marriott Central Reservations at 1-800-228-9290.
Book your room on this link.
We look forward to seeing you at Meet the Experts Transporter Conference - Boston/Cambridge, 2019.