Group Leader, DMPK Global Pharmaceutical R&D AbbVie Inc. North Chicago, IL, USA
Dan Bow leads the drug transporter group at AbbVie, where he is responsible for drug transporter activities and provides pre-clinical DMPK support for multiple discovery and development projects. He received his PhD from the University of Aberdeen, Scotland where his research focused on renal organic anion and cation transport. In 2002, he moved to the United States and continued research in the area of renal transport with a visiting fellow position at the National Institute of Environmental Health Sciences in North Carolina. Prior to joining AbbVie in 2007, he held a post doctoral position at the University of North Carolina at Chapel Hill, where his research interests were on drug transporter localization in hepatocytes, transporter expression, and canalicular membrane development in the hepatocyte sandwich-culture model. Current research interests include the interpretation of endogenous substrate exposure related to metabolism and transport, drug and drug transporter trafficking, and the translation of pre-clinical transporter data to the clinic. In 2013, he was a co-author on an International Transporter Consortium (ITC) white paper; “In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development” and in 2014 was invited to join the ITC as a main committee member. Dan chaired the AAPS Drug Transporter Focus Group from 2012-2014, and was recently elected to serve as AAPS section vice chair for PPDM (2015). He has been involved in organization of the bi-annual AAPS Drug Transporter workshop since 2011 and partnered with the ITC to co-chair the 2015 AAPS/ITC Joint Workshop on Drug Transporters.