Head of Division of Pharmacology Leiden Academic center for Drug Research (LACDR), Leiden University, The Netherlands
Elizabeth de Lange, PhD, is Head of Division of Pharmacology at the Leiden Academic center for Drug Research (LACDR), Leiden University, the Netherlands. Her ultimate aim is to aid in the prediction of the dose-response relationship of CNS drugs in the clinical setting on the basis of preclinical data (translational research) by identification and characterization of the rate and extent of systems processes that govern the dose-response relationship of CNS drugs in health and CNS disorders. This includes not only BBB transport but also intra-brain distribution of drugs and associated CNS effects. To that end, Elizabeth de Lange’s group combines comprehensive preclinical experimentation (intracerebral microdialysis, EEG monitoring, PET scanning, etc) with advanced mathematical modeling. She provides general pharmacokinetic and BBB lecture series for Bio-Pharmaceutical Sciences Students. Furthermore, Dr de Lange has been the cofounder and (co-)Chair at the 1st, 2nd and 5th of the series of International Symposia on Microdialysis in Drug Research and Development. She has been the Chair of the Organizing Committee of the 9th International CerebroVascular Biology Conference, held in Leiden, The Netherlands, in 2011. Furthermore, she has been the chair of the Microdialysis Focus Group (2005-2007), of the Pharmacokinetics Pharmacodynamics and drug metabolism (PPDM)(2012)section, and OF the Annual Meeting Programming Committee (AMPC) (2014) of the American Association of Pharmaceutical Scientists (AAPS), With her company In Focus (www.infocus-ecmdelange.nl) she provides courses, training and advice within her area of expertise on microdialysis, PK, PKPD, BBB, and intra-brain distribution.