Like much of the world, we are limiting our travel and putting face-to-face meetings on hold as a result of the COVID-19 pandemic. The pace of scientific progress continues however, and with it the need for discourse and debate. Since taking the difficult decision to postpone our Meet the Experts Transporter Conference at the start of the year, we have received a significant level of interest from our colleagues in the transporter field for an alternative venue in which to showcase the latest in transporter research. We are therefore delighted to announce the start of the SOLVO Biotechnology Meet the Experts Transporter Webinar Series!
Date: 6 April 2022
8:00 am (PT)
11:00 am (ET)
4:00 pm (GMT)
5:00 pm (CET)
6:00 pm (IST)
12:00 pm (Beijing)
01:00 am (Tokyo, Seoul)
Efflux Transporters – Challenges, Failures, and Success Stories
SOLVO distinguishes itself by the emphasis we put on continuously improving the quality, accuracy, and predictive value of our in vitro assays to deliver high quality data to our clients. Although our service portfolio is constantly growing, much of the efforts, failures, and success stories of our Research and Development team often remains hidden behind the scenes. While efflux transporters have a key role in drug absorption, distribution, and clearance and are common mediators of drug-drug interactions, their investigation has always been challenging. Due to their localization and mode of action, in vitro methods available for their investigation range from rather simple methods to complex models. When comparing the most commonly used assay systems, we need to consider or avoid endogenous efflux transporter expression, as well as drug concentration at the binding site of transporter, and assay duration. Despite such differences, however, the calibration of vesicular transport versus transcellular transport assays with drugs of known DDI effects resulted in comparable DDI prediction accuracy, both for P-gp and BCRP. While the in vitro transporter assays may seem straightforward, it is recognized that experimental outcomes and predictive value are influenced by several factors. Therefore, better understanding of these experimental models, more complex study setups using the appropriate controls are needed to acquire high quality in vitro data that can be reliably used for establishing physiologically based PK models. Considering all these requirements, our latest webinar aims to give an insight into the challenges, difficulties, and ideas behind our assay developments.
Please click here to download the webinar slides!