July 03, 2020
Like much of the world, we are limiting our travel and putting face-to-face meetings on hold as a result of the COVID-19 pandemic. The pace of scientific progress continues however, and with it the need for discourse and debate. Since taking the difficult decision to postpone our Meet the Experts Transporter Conference at the start of the year, we have received a significant level of interest from our colleagues in the transporter field for an alternative venue in which to showcase the latest in transporter research. We are therefore delighted to announce the start of the SOLVO Biotechnology Meet the Experts Transporter Webinar Series!
Title: New Insights on Fat-soluble Vitamin Efflux by the Intestine
Presenter: Emmanuelle Reboul, PhD, Head of the research axis “Bioavailability of Micronutrients” in the “Human Micronutrition” team of the “Cardiovascular and Nutrition Center of Marseille, France
Date: 16 July 2020, 4 pm (GMT)
Summary: Efficient intestinal absorption of dietary fat-soluble vitamins is required in most people to ensure an adequate status. However, fat-soluble vitamin absorption process is more complex than previously thought and our understanding of the molecular mechanisms responsible for their uptake and efflux at the brush-border level has substantially progressed over the past decade. We recently investigated the involvement of ATP-binding cassette B1 (ABCB1, P-glycoprotein) in fat-soluble vitamin intestinal efflux. Interestingly, vitamin D, E and K apical effluxes were decreased by chemical inhibition of ABCB1 in Caco-2 cells and increased by ABCB1 overexpression in Griptites or MDCKII cells. The involvement of ABCB1 in vitamin transport was further confirmed in Abcb1-/- mice. We also highlighted that a trans-intestinal efflux of vitamin D could occur and that it was partly mediated by ABCB1. ABCB1 thus appear as a key protein in fat-soluble vitamin transport as it is involved in neo-absorbed vitamin efflux by the enterocytes, and that it may also contribute to their transintestinal excretion and impact on their status. Identifying other proteins involved in intestinal uptake and transport of fat-soluble vitamins across the intestinal cells, as well as understanding their molecular functioning, is of major importance. Indeed, some of these proteins are already targets for the development of drugs able to reduce cholesterol or lipid absorption and these drugs may also interfere with fat-soluble vitamin uptake. A better understanding of the molecular mechanisms involved in fat-soluble vitamin absorption is a priority to better optimize their bioavailability.
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