Citoxlab group services

Toxicology services   

  • General toxicology in all species
  • Special toxicology : infusion, Inhalation, Dermal, Ocular
  • Immunotoxicology
  • Regenerative medicine
  • Reproductive toxicology including minipigs and NHPs
  • Carcinogenicity studies also in rasH2 and p53+/- mice
  • Genetic toxicology: ICH compliant package
  • In vitro toxicology : BCOP, h-CLAT, KeratinoSens™, DPRA, Photo 3T3-NRU,
  • Episkin™, chicken eye test
  • Agrochemical / chemical / REACH
  • QSAR
  • Physico-chemical testing
  • Ecotoxicology: wide range of test species

Safety pharmacology   

Integrated safety pharmacology in toxicology studies

  • CV (JET), BP
  • Respiratory (JET), plethysmography
  • CNS (FOB) and JET-EEG

Safety pharmacology core battery

In vitro assays

  • GLP compliant ion channel testing panel (hERG +5)
  • CNS ex vivo models for seizure liability screening

Screening and follow-up models

  • Rodent and non-rodent LVP telemetry
  • Anesthetized models
  • Polysomnography
  • Gastrointestinal motility

DMPK, Bioanalysis, Biomarkers   

  • 14C and 3H ADME studies in all species
  • In vitro metabolic clearance, metabolite ID and profiling, DDI package (metabolism and transporters)
  • Bioanalysis: LC -MS/MS, GC-MS/MS, LC -ICP/MS, LC -Radiodetection, ELISA, RIA
  • Toxicogenomics, miRNA: Affymetrix™ accredited service provider, next generation sequencing (Illumina®)
  • Immunology: 10-color flow cytometer, Luminex, Meso Scale

Medical Device   

  • Biocompatibility testing
  • Cardiovascular stents, electrophysiology and structural heart studies
  • Long-bone defects and craniomaxillofacial/dental models
  • Spinal fusion models
  • Joint and cartilage repair models
  • Regenerative medicine (growth factors, biomaterials, cell and gene therapy)

Specialized expertise   

  • Juvenile studies including minipigs
  • Ototoxicity in rats
  • Fertility studies in rodents and NHPs
  • Radiation safety and efficacy studies
  • Drug transporter studies and Drug-Drug Interactions
  • Tissue Cross Reactivity (TCR): human and animal tissue banks
  • Gene therapy vector biodistribution via qPCR
  • ES cell testing: devTOX™ and cardioTOX™ (with Stemina)
  • Lead optimization and predictive toxicology services: Leadscreen™



For more information please visit Citoxlab website.