Citoxlab group services
Toxicology services
- General toxicology in all species
- Special toxicology : infusion, Inhalation, Dermal, Ocular
- Immunotoxicology
- Regenerative medicine
- Reproductive toxicology including minipigs and NHPs
- Carcinogenicity studies also in rasH2 and p53+/- mice
- Genetic toxicology: ICH compliant package
- In vitro toxicology : BCOP, h-CLAT, KeratinoSens™, DPRA, Photo 3T3-NRU,
- Episkin™, chicken eye test
- Agrochemical / chemical / REACH
- QSAR
- Physico-chemical testing
- Ecotoxicology: wide range of test species
Safety pharmacology
Integrated safety pharmacology in toxicology studies
- CV (JET), BP
- Respiratory (JET), plethysmography
- CNS (FOB) and JET-EEG
Safety pharmacology core battery
In vitro assays
- GLP compliant ion channel testing panel (hERG +5)
- CNS ex vivo models for seizure liability screening
Screening and follow-up models
- Rodent and non-rodent LVP telemetry
- Anesthetized models
- Polysomnography
- Gastrointestinal motility
DMPK, Bioanalysis, Biomarkers
- 14C and 3H ADME studies in all species
- In vitro metabolic clearance, metabolite ID and profiling, DDI package (metabolism and transporters)
- Bioanalysis: LC -MS/MS, GC-MS/MS, LC -ICP/MS, LC -Radiodetection, ELISA, RIA
- Toxicogenomics, miRNA: Affymetrix™ accredited service provider, next generation sequencing (Illumina®)
- Immunology: 10-color flow cytometer, Luminex, Meso Scale
Medical Device
- Biocompatibility testing
- Cardiovascular stents, electrophysiology and structural heart studies
- Long-bone defects and craniomaxillofacial/dental models
- Spinal fusion models
- Joint and cartilage repair models
- Regenerative medicine (growth factors, biomaterials, cell and gene therapy)
Specialized expertise
- Juvenile studies including minipigs
- Ototoxicity in rats
- Fertility studies in rodents and NHPs
- Radiation safety and efficacy studies
- Drug transporter studies and Drug-Drug Interactions
- Tissue Cross Reactivity (TCR): human and animal tissue banks
- Gene therapy vector biodistribution via qPCR
- ES cell testing: devTOX™ and cardioTOX™ (with Stemina)
- Lead optimization and predictive toxicology services: Leadscreen™
For more information please visit Citoxlab website.
