Recent Developments

SOLVO is continuously expanding its product and service portfolio, with 10-20 new launches annually. Our focus is to develop new products and services based on the latest results in drug transporter science, the needs of the pharmaceutical industry and suggestion of the various regulatory agencies such as FDA and EMA regarding transporter related drug drug interaction studies. You can easily catch up with our latest developments by visiting this page which summarizes the newest offerings in our portfolio. Want our news on our latest developments delivered directly to your inbox?

Get the news automatically by subscribing via: Sign up for e-mail Newsletter!

Service and Product Launches

2024 Q2

• Vesicular Transport Assays BCRP- HEK293 with sulfasalazine

2023 Q4

• Vesicular Transport Assays mouseBcrp- HEK293 with estrone-3-sulfate (E3S)

2023 Q2

• Uptake Transporter Assays RFVT3-HEK293 with Riboflavin

2023 Q1

• Vesicular Transport Assays MRP1(ABCC1) -HEK293 with estradiol-17β-D-glucuronide
• Uptake Transporter Assays ratEnt1 with adenosine

2022 Q4

• Uptake Transporter Assays ratNis-HEK293 with iodide
• Vesicular Transport Assays MRP3-HEK293 with coproporphyrine I
• MDCKII Monolayer Assays Abcb1KO-MDCKII-cyMdr1 with digoxin as probe substrate

2022 Q3

• Uptake Transporter Assays ASCT2-HEK293 with serine

2022 Q2

• Metabolism Services
• Uptake Transporter Assays ASCT1-HEK293 with serine

2022 Q1

• DILIScreen Services - Early Drug-Induces Liver Injury (DILI) risk assessment via transporter interaction assays
• MDCKII Monolayer Assays Abcb1KO-MDCKII-ratMdr1a with digoxin
• MDCKII Monolayer Assays Abcb1KO-MDCKII-mouseMdr1a with digoxin
• Uptake Transporter Assays LAT2-HEK293 with leucine

The LAT2 transporter was made newly available in our portfolio!

• PREDIVEZ™ Vesicular Transport Reagent Kits MDR1-HEK293 for Predivez Reagent kit

2021 Q4

• BCS-based Biowaiver Permeability Classification
• Uptake Transporter Assays MATE2-HEK293 with metformin
• Uptake Transporter Assays MATE1-HEK293 with metformin

2021 Q3

• Uptake Transporter Assays OAT7-HEK293 with estrone-3-sulfate

2021 Q2

• SOLVO TranSelect™ Solute Carrier Transporter-Overexpressing HEK293 Cells 

2021 Q1

• Vesicular Transport Membranes - Vesicular Transport Assays  ratBcrp-HEK293 with estrone-3-sulfate (E3S)
• MDCKII Monolayer Assays Abcb1KO-MDCKII-MDR1 and MDCKII with quinidine
• Vesicular Transport Assays MDR1-HEK293 with vincristine sulphate

2020 Q4

• Uptake Transporter Assays OCTN1-HEK293 with tetraethyl-ammonium (TEA)
• Vesicular Transport Assays BCRP-HEK293 with uric acid

The OCTN1 and BCRP assay was fully characterized with a clinically relevant substrate.

2020 Q3

• Uptake Transporter Assays THTR1-HEK293 and THTR2-HEK293 with thiamine

The THTR1 and THTR2 transporter were made newly available in our portfolio!

• P-gp are now available: PSC-833 (valspodar), verapamil and ketoconazole
• BCRP are now available: Ko143, novobiocin, FTC

Additional P-gp inhibitors were characterized for P-gp (MDR1) and BCRP in Caco-2 and newly added to our portfolio!

• Caco-2 Monolayer Assay  Caco-2 with sulfasalazine

Our Caco-2 assay has in addition to Estrone-3-sulfate now also been characterized with sulfasalazine as BCRP probe substrate!

• Vesicular Transport Assays BCRP-HEK293 with rosuvastatin

The BCRP assay was fully characterized with a clinically relevant substrate.

• Uptake Transporter Assays dogSglt2 (dSglt2)-HEK293 with methyl-α-D-glucopyranoside (AMG)

The dogSglt2 transporter was made newly available in our portfolio!

• Uptake Transporter Assays mouseSglt2 (mSglt2)-HEK293 with methyl-α-D-glucopyranoside (AMG)

The mouseSglt2 transporter was made newly available in our portfolio!

• Uptake Transporter Assays SGLT6-HEK293 with myo-inositol (MI)

The SGLT6 transporter was made newly available in our portfolio!

• MDCKII Monolayer Assays Abcb1KO-MDCKII-MDR1 with digoxin

Human MDR1 was expressed into canine-P-gp knock-out MDCKII cells transfected and the cell line added newly to our portfolio!

• Uptake Transporter Assays SGLT5-HEK293 with D-fructose

The SGLT5 transporter was made newly available in our portfolio!

• Uptake Transporter Assays OAT4-HEK293 with estrone-3-sulfate
• Uptake Transporter Assays OAT1-HEK293 and OAT3-HEK293 with uric acid

In addition to using uric acid as substrate for OAT4, the assay was characterized with E3S as well! Uric acid was fully characterized as new substrate in our existing for OAT1 and OAT3 cell lines!

2020 Q2

• Uptake Transporter Assays LAT1-HEK293 with leucine

The LAT1 transporter was made newly available in our portfolio!

• Uptake Transporter Assays NIS-HEK293 with iodide

The NIS transporter was made newly available in our portfolio!

• Uptake Transporter Assays OCT1-HEK293 with sumatriptan

The OCT1 assay was fully characterized with a clinically relevant substrate and newly added to our portfolio.

2020 Q1

• Uptake Transporter Assays OATP1B1 rosuvastatin

The OATP1B1 assay was fully characterized with a clinically relevant substrate and newly added to our portfolio.

• Uptake Transporter Assays  OATP1B3 rosuvastatin

The OATP1B3 assay was fully characterized with a clinically relevant substrate and newly added to our portfolio.

• Caco-2 Monolayer Assay   Caco-2 with CDCF-DA

The Caco-2 assay was set-up for testing MRP2 substrate CDCF-DA, confirming this Caco-2 clone has activity of MRP2.

2019 Q4

• Uptake Transporter Assays  MCT8

The MCT8 transporter was made newly available in our portfolio!

• Uptake Transporter Assays  MCT10

The MCT10 transporter was made newly available in our portfolio!

• Uptake Transporter Assays  ratNtcp-HEK293

The rat Ntcp transporter was made newly available in our portfolio!

2019 Q3

• Uptake Transporter Assays - Uptake Transporter Kits  HEK-based PREDICELL products: NTCP, OAT1, OAT3, OCT1, OCT2, OATP2B1

The PREDICELL product line was updated for use of HEK293 cells expressing the transporters of interest, instead of CHO cells used previously in the product.

2019 Q2

• Uptake Transporter Assays  OATP1B1 with coproporphyrin I

The OATP1B1 assay was fully characterized with a clinically relevant substrate and newly added to our portfolio.

• Uptake Transporter Assays  OATP1B3 with coproporphyrin I

The OATP1B3 assay was fully characterized with a clinically relevant substrate and newly added to our portfolio.

2019 Q1

• Uptake Transporter Assays  OATP2B1 expressed in HEK293 cells instead of MDCKII

An improved, HEK293-derived cell line was developed to replace the historically used MDCKII-OATP2B1 cell line.

2018 Q4

• Vesicular Transport Membranes - Vesicular Transport Assays  MRP1 with estradiol-17-beta-glucuronide

The MRP1 assay was fully characterized with a well known substrate and newly added to our portfolio.

• Vesicular Transport Membranes - Vesicular Transport Assays  MRP2 with coproporphyrin I

The MRP2 assay was fully characterized with a clinically relevant substrate and newly added to our portfolio.

2018 Q3

• Uptake Transporter Services – inhibition and substrate assessment studies  OAT4-HEK293-LV with Uric Acid

2018 Q2

• Uptake Transporter Services – inhibition and substrate assessment studies  OAT2v1-HEK293-LV with Creatinine and with Uric Acid
• Vesicular Transport Membranes - Vesicular Transport Assays cyBsep-HEK293-LV with Taurocholate

2018-Q1

• MDCKII Monolayer Assays MDCKII-cyBcrp

• Uptake Transporter Services – inhibition and substrate assessment studies ASBT-HEK293-LV with Taurocholate, OSTα/β-HEK293-LV with Estrone-3-Sulfate, rAsbt-HEK293-LV with Taurocholate
• Vesicular Transport Membranes - Vesicular Transport Assays  dogBsep-HEK293-LV with Taurocholate

• ProxTox-HTS - Predictive Nephrotoxicity Assay:  a new tool for accurate in vitro high-throughput human nephrotoxicity prediction in collaboration with CellBae

2017-Q4

• Uptake Transporter Services – inhibition and substrate assessment studies rOstα/β-HEK293-LV with Estrone-3-Sulfate

2017-Q2

• Vesicular Transport Membranes - Vesicular Transport Assays  cyMdr1-HEK293, cyBcrp-HEK293
• Uptake Transporter Services – inhibition and substrate assessment studies  OAT2v1-HEK293 with cGMP

2017-Q1

• Uptake Transporter Services – inhibition and substrate assessment studies rOatp1a1-HEK293 with Taurocholate, ENT4-HEK293-LV with MPP+, NTCP-HEK293-LV with Taurocholate

• LLC-PK1 Monolayer Assays LLC-PK1-MDR1, LLC-PK1-mMdr1a

2016-Q4

Vesicular Transport Membranes - Vesicular Transport Assays MRP2-HEK293, BCRP-HEK293 with Rosuvastatin

• PREDIVEZ™ Vesicular Transport Reagent Kits MRP2-HEK293 for Predivez Reagent kit

2016-Q3

• PREDIVEZ™ Vesicular Transport Reagent Kits MRP5-HEK293 for Predivez Reagent kit

• Vesicular Transport Membranes - Vesicular Transport Assays MDR1-HEK293-VT

2016-Q2

• Uptake Transporter Assays SGLT2-HEK293

2016-Q1

• Vesicular Transport Membranes - Vesicular Transport Assays MRP3-HEK293 BCRP-HEK293

2015-Q3

• Vesicular Transport Membranes - Vesicular Transport Assays ratMrp3-HEK293 VT ratMdr1b-HAM Sf9 VT mouseMdr1a-HEK293 VT

2015-Q2

• Uptake Transporter Services – inhibition and substrate assessment studies MDCKII-CNT1 MDCKII-CNT2 MDCKII-CNT3 MDCKII-ENT1 MDCKII-ENT2
• Vesicular Transport Membranes BSEP-HEK293 VT
• Vesicular Transport Membranes BCRP-HEK293 VT
• Uptake Transporter Services – inhibition and substrate assessment studies HEK293-OATP1B1 - Olmesartan and Estrone-3-sulfate as probe substrate
• LLC-PK1 MonolayerAssays LLC-PK1-rMdr1a

2015-Q1

• Vesicular Transport Membranes MRP3-HEK293 VT
• LLC-PK1 MonolayerAssays LLC-PK1-BCRP

2014-Q4

• Vesicular Transport Membranes - Vesicular Transport Assays ratBsep-HEK293 VT

2014-Q3

• Sandwich-cultured hepatocyte services Sandwich-cultured hepatocyte services certified by Qualyst
• Renal Proximal Tubule Cell Monolayer Assay Renal Proximal Tubule Cell Monolayer Assay in collaboration with NewCastle University

2014-Q2

• PreadyPort Product line PreadyPort-BCRP-OATP2B1 24- and 96-well plates

2013-Q4

• LC/MS-MS Quantification of Transporter Proteins PREDICELL Product line MATE2K-PREDICELL NTCP-PREDICELL OAT3-PREDICELL OCTN1-PREDICELL
• Uptake Transporter Services – inhibition and substrate assessment studies HEK-ratOatp1b2 - Taurocholate as probe substrate

2013-Q3

• MDCKII Monolayer Assays MDCKII-OAT1/BCRP: a renal vectorial transport model
• PREDICELL Product line MATE1-PREDICELL OCT1-PREDICELL OCTN2-PREDICELL

2013-Q2

• Molecular Imaging - Preclinical and Clinical PET & PET tracer synthesis (collaboration with AIT) Uptake Transporter Services – inhibition and substrate assessment studies MDCKII-MATE1 - TEA and metformin as probe substrates MDCKII-OAT3 - E3S as probe substrate

2013-Q1

• Uptake Transporter Services – inhibition and substrate assessment studies MDCKII-MATE2 - TEA and metformin as probe substrates CHO-OCT2 - MPP+ as probe substrate
• PreadyPort Product line PreadyPort-BCRP 96-well plates Membrane Product BSEP-Hi5 VT membrane