PREDICELL™ Kits
Description
PREDICELLTM, the world’s first commercially available ready-to-use uptake transporter assay kits for the following transporters: ASBT MATE1 MATE2K NTCP OAT1 OAT3 OATP1B1 OATP1B3 OATP2B1 OATP1A2 OCT1 OCT2 OCTN1 OCTN2 PREDICELLTM kits enable interaction studies with drug uptake transporters. The kits contain transfected as well as parental control cells on tissue culture plates. Transporter interactions are detected through changes in accumulation inside the cells. The assays are available as:
- 96-well kit for inhibition studies
- 24-well kit for direct uptake studies (substrate assessment)
Benefits
With the PREDICELLTM Kits SOLVO aims to provide access to uptake transporters
- if you prefer in-house studies
- if you do not have cell culturing capacities
- if you do not plan to acquire or develop cell lines
In the box
- Plates with cells
- User’s Manual with sample transport assay protocol
- Product data sheet
- Optional reagents
- Thermal and mechanical insulation
Additional reagents to conduct a study straight out of the box can be included upon request..
How to perform uptake assay with ready to use PREDICELL kit? Watch our PREDICELLTM video in the Download Center! - Click here!
Technical aspects
Standard timeline comprises seeding on Monday, Kit assembly and dispatch on Tuesday and delivery on Wednesday or Thursday (depending on your location). Studies may be conducted within 24 hours upon delivery. Alternative schedules are possible upon request. One 30x30x40 cm box contains up to five plates, documentation and optional reagents. During shipment, the activity of uptake transporters in the PREDICELLTM Kit remains stable during shipment for 48 hours, as shown in Figure 1.
Figure 1.: Testing insulation capabilities of the packaging in a 4°C refrigerator. Estrone-3-sulfate uptake activity of OATP1B1 trasfected cells and TEA uptake activity of OCT1 cells were tested on packaged cells put into the refrigerator as well as control cells kept in incubator. Learn more about the scientific background of the uptake transporter assay technology.
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