Molecular Imaging – Preclinical and Clinical PET
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Description
SOLVO Biotechnology (SOLVO) and Austrian Institute of Technology (AIT), Austria, have established a strategic partnership with the goal to offer Preclinical and Clinical Molecular Imaging Services and a wide portfolio of related Services, including transporter-specific microPET-MRI.
SERVICE PORTFOLIO
- Development of PET tracers
- Direct radiolabelling of drug candidates
- Clinical PET
- Preclinical: Small-animal PET & MRI
- Animal models (e.g. tumor, epilepsy, transgenic animals)
- Kinetic modelling
- Assessment of radiotracer metabolism
- In vivo brain distribution studies
- In vivo drug-drug interaction studies
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Watch the recorded WEBINAR presented on June 5th, 2013 by Oliver Langer, PhD: “Imaging of ABC transporters at the blood-brain barrier with positron emission tomography”.
Small-animal positron emission tomography (PET) allows measuring the tissue distribution and pharmacokinetics of radiolabelled molecules non-invasively in living animals (e.g. mice, rats, rabbits).
For PET imaging positron-emitting radionuclides, such as carbon-11 (11C), fluorine-18 (18F), gallium-68 (68Ga) or iodine-124 (124I) need to be incorporated into the molecule of interest. PET data combined with magnetic resonance imaging (MRI) data provide detailed anatomical information about the tissue distribution of radiolabelled molecules.
AIT’s Molecular Imaging Group has access to a GMP-certified radiochemistry laboratory including a cyclotron for production of PET radionuclides (11C, 18F) and automated synthesis systems. Moreover, procedures for labelling of molecules with 68Ga and 124I are in place. A palette of established PET tracers from literature is readily available (e.g. FDG, FDOPA).
AIT´s imaging laboratory is equipped with a Siemens microPET Focus 220 scanner and a Bruker 1 Tesla ICON MRI scanner. The laboratory includes a metabolite lab, an autoradiography system, a computer-based well counter, and all equipment necessary for cell culture work. The Molecular Imaging Group has built up a large body of expertise in different radiolabelling methods and in performing small-animal studies. A large number of established imaging protocols, standard operating procedures (SOPs) and data analysis tools guarantee reliable scientific results.
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Figure 1. Brain distribution of 11 C-verapamil (MDR1/P-gp substrate) in the presence (A), and in the absence (B) of tariquidar (MDR1/P-gp inhibitor) on whole body scan images of mice. Left: MR image, middle: coregistered MR-PET image, right: PET image.
Learn more about the small animal Molecular Imaging Services available through Solvo!
Learn more about the PET Imaging technology!
