PreadyPort™
Description
PreadyPortTM, the Ready-to-use Transfected MDCKII Monolayer Assay Kits, contain differentiated MDCKII cells expressing a selected drug transporter on 24- or 96-well cell culture insert plates. PreadyPortTM Kits are suitable for both substrate and inhibition assessments and are often used to model the net transport events of important fluid compartment barriers in the organism that expresses a specific transporter at a high level. The PreadyPortTM Kits allow researchers to perform transporter interaction studies on monolayers without bothering about cell line licensing and culturing. The innovative shipping medium, developed and patented by ReadyCell, preserves the properties of the barrier throughout transportation, allowing us to provide customers with a robust, ready-to-use drug transport assay kit. Monolayer assays using transfected MDCKII cells are widely recognized tools, recommended by the FDA, to study the interaction of drugs with efflux transporters. SOLVO Biotechnology introduced PreadyPortTM in collaboration with ReadyCell (Spain). Applications- Substrate assessment (direct transport studies) on MDR1, BCRP, OATP2B1
- Inhibitor assessment (drug-drug interaction studies) on MDR1, BCRP, OATP2B1
- Models the net transport events of barriers where MDR1, BCRP, OATP2B1 are present.
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