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Catalog > Products > Ready-to-use Monolayers > PreadyPort™

PreadyPort™

Product	Transporter	Technology	Barrier
SB PP BCRP 24TW	BCRP	Monolayer Assay	Blood-brain-barrier Hepatic Barrier Intestinal Barrier
SB PP BCRP mix 24TW	BCRP	Monolayer Assay	Blood-brain-barrier Hepatic Barrier Intestinal Barrier
SB PP MDR1 24TW	MDR1/P-gp	Monolayer Assay	Blood-brain-barrier Intestinal Barrier Hepatic Barrier Renal Barrier
SB PP MDR1 mix 24TW	MDR1/P-gp	Monolayer Assay	Blood-brain-barrier Intestinal Barrier Hepatic Barrier Renal Barrier
SB PP MDR1 96MW	MDR1/P-gp	Monolayer Assay	Blood-brain-barrier Intestinal Barrier Renal Barrier Hepatic Barrier
SB PP MDR1 mix(1:1) 96MW	MDR1/P-gp	Monolayer Assay	Blood-brain-barrier Intestinal Barrier Renal Barrier Hepatic Barrier
SB PP MDR1 mix(3:1) 96MW	MDR1/P-gp	Monolayer Assay	Blood-brain-barrier Intestinal Barrier Hepatic Barrier Renal Barrier
SB PP MDR1 mix(c) 96MW	MDR1/P-gp	Monolayer Assay	Blood-brain-barrier Intestinal Barrier Renal Barrier Hepatic Barrier
SB PP CTRL 24TW		Monolayer Assay
SB PP CTRL 96MW		Monolayer Assay

Description

PreadyPort^TM, the Ready-to-use Transfected MDCKII Monolayer Assay Kits, contain differentiated MDCKII cells expressing a selected drug transporter on 24- or 96-well cell culture insert plates.

PreadyPort^TM Kits are suitable for both substrate and inhibition assessments and are often used to model the net transport events of important fluid compartment barriers in the organism that expresses a specific transporter at a high level.

The PreadyPort^TM Kits allow researchers to perform transporter interaction studies on monolayers without bothering about cell line licensing and culturing. The innovative shipping medium, developed and patented by Advancell, preserves the properties of the barrier throughout transportation, allowing us to provide customers with a robust, ready-to-use drug transport assay kit.
Monolayer assays using transfected MDCKII cells are widely recognized tools, recommended by the FDA, to study the interaction of drugs with efflux transporters.

SOLVO Biotechnology introduced PreadyPort^TM in collaboration with ADVANCELL.

Applications

• MDR1 substrate assessment (direct transport studies)
• MDR1 inhibitor assessment (drug-drug interaction studies)
• Models the net transport events of barriers like the human blood-brain-barrier and the intestine

 

 

Features Differentiated MDCKII-MDR1 barrier (11 day system) Ready-to-use The Kit can be used up to 7 days after reception 24-TranswellTM (Costar) or 96-Multiwell (Millipore) format Up to 4 days of transportation and storage at room temperature in proprietary shipping medium Shipping medium is easy to remove after liquefaction at 37 °C Available under a Limited Single-use License without extra charge Sample Assay Protocol Sample Plate Layouts

Benefits Available on demand User-friendly system and easy-handling Flexibility: a window of 4 days for transport measurements Adaptable to automation Transporter experiments without in-house cell propagation Transporter experiments without in-house cell line development or acquisition

For detailed information on the PreadyPort^TM-MDR1 Kit and validation data, please click here.
We highly recommend reading the Chemicals and Instruments needed and the Tips for Success guide before your PreadyPort^TM Kits arrive.

The PreadyPort^TM product line will be expanded with MDCKII-BCRP and MDCKII-OATPB/BCRP in the near future.