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Products
- Other Products
- Licensing
- HepatoPac®
- Ready-to-use Monolayers
- PreadyPort™
- SB PP BCRP 24-well
- SB PP BCRP 96-well
- SB PP MDR1 24-well
- SB PP MDR1 96-well
- SB PP CTRL 24-well
- SB PP CTRL 96-well
- SB PP BCRP mix 24TW
- SB PP MDR1 mix 24TW
- SB PP MDR1 mix(1:1) 96MW
- SB PP MDR1 mix(3:1) 96MW
- SB PP MDR1 mix(c) 96MW
- SB PP BCRP-OATP2B1 24TW
- SB PP BCRP-OATP2B1 96MW
- SB PP BCRP mix(1:1) 96MW
- SB PP BCRP mix(3:1) 96MW
- SB PP OATP2B1-BCRP mix 24TW
- SB PP OATP2B1-BCRP mix 96TW
- CACOREADY™
- PreadyPort™
- Efflux Transporter Kits
- Uptake Transporter Kits
- TranSelect™ Cryopreserved Cells
- PREDICELL™ Kits
- SB-OAT1-PREDICELL™ UT-24w Kit
- SB-OAT1-PREDICELL™ UT-96w Kit
- SB-NTCP-PREDICELL™ UT-24w Kit
- SB-NTCP-PREDICELL™ UT-96w Kit
- SB-OATP1B1-PREDICELL™ UT-24w Kit
- SB-OATP1B1-PREDICELL™ UT-96w Kit
- SB-OATP1B3-PREDICELL™ UT-24w Kit
- SB-OATP1B3-PREDICELL™ UT-96w Kit
- SB-OCT2-PREDICELL™ UT-24w Kit
- SB-OCT2-PREDICELL™ UT-96w Kit
- SB-MATE1-PREDICELL™ UT-24w Kit
- SB-MATE1-PREDICELL™ UT-96w Kit
- SB-MATE2-K-PREDICELL™ UT-24w Kit
- SB-MATE2-K-PREDICELL™ UT-96w Kit
- SB-OAT3-PREDICELL™ UT-96w Kit
- SB-OCT1-PREDICELL™ UT-24w Kit
- SB-OCT1-PREDICELL™ UT-96w Kit
- SB-OCTN1-PREDICELL™ UT-24w Kit
- SB-OCTN1-PREDICELL™ UT-96w Kit
- SB-OCTN2-PREDICELL™ UT-24w Kit
- SB-OCTN2-PREDICELL™ UT-96w Kit
- SB-ASBT-PREDICELL™ UT-24w Kit
- SB-ASBT-PREDICELL™ UT-96w Kit
- SB-OATP1A2-PREDICELL™ UT-24w Kit
- SB-OATP1A2-PREDICELL™ UT-96w Kit
- SB-OATP2B1-PREDICELL™ UT-24w Kit
- SB-OATP2B1-PREDICELL™ UT-96w Kit
- SB-OAT3-PREDICELL™ UT-24w Kit
- Membrane Preparations
- Vesicular Transport Membranes
- SB BCRP HEK293 Membrane
- SB BSEP HEK293 Membrane
- SB MDR1/P-gp HEK293 Membrane
- SB MRP1 HEK293 Membrane
- SB MRP2 HEK293 Membrane
- SB MRP3 HEK293 Membrane
- SB MRP4 HEK293 Membrane
- SB MRP5 HEK293 Membrane
- SB cyMdr1 HEK293 Membrane
- SB cyBcrp HEK293 Membrane
- SB cyBsep HEK293 Membrane
- SB dogBsep HEK293 Membrane
- SB mouseBcrp HEK293 Membrane
- SB mouseMdr1a HEK293 Membrane
- SB ratBcrp HEK293 Membrane
- SB ratBsep HEK293 Membrane
- SB ratMdr1b Sf9 HAM Membrane
- SB ratMrp2 HEK293 Membrane
- SB ratMrp3 HEK293 Membrane
- SB BSEP Hi5 Membrane
- Control Membranes
- Vesicular Transport Membranes
Metabolism Services
Services
- DILIScreen Services
- B-Clear® assays
- Proximal Tubule Cell Monolayer Assays
- Hepatic Kp,uu Determination
- Lysosomal Trapping Assays
- Hepatocyte Uptake Assays
- Caco-2 Services
- Caco-2 Monolayer Assay
- Caco-2 permeability testing
- Caco-2 BCRP substrate assessment / Chemical inhibition
- Caco-2 MDR1 substrate assessment / Chemical inhibition
- Caco-2 MRP2 substrate assessment / Chemical inhibition
- Caco-2 BCRP inhibitor assessment
- Caco-2 BCRP/MRP2 inhibitor assessment
- Caco-2 MDR1 inhibitor assessment
- Caco-2 MRP2 inhibitor assessment
- Caco-2 Transporter Knockout Cell-Based Assays
- Caco-2 BCRP substrate assessment / Transporter knockout
- Caco-2 MDR1 substrate assessment / Transporter knockout
- Caco-2 MRP2 substrate assessment / Transporter knockout
- Caco-2 MDR1/BCRP substrate assessment / Transporter double knockout
- Caco-2 MDR1/MRP2 substrate assessment / Transporter double knockout
- Caco-2 MRP2/BCRP substrate assessment / Transporter double knockout
- Excipients and Absorption Service
- BCS-based Biowaiver Permeability Classification (Caco-2 model)
- Caco-2 Monolayer Assay
- Efflux Transporter Services
- ATPase Assays
- Vesicular Transport Assays
- BCRP Vesicular Transport Assay - Estrone 3-sulfate
- BSEP Vesicular Transport Assay
- MDR1/P-gp Vesicular Transport Assay
- MRP1 Vesicular Transport Assay - Leukotriene C4
- MRP2 Vesicular Transport Assay - β-Estradiol 17-(β-D-glucuronide)
- MRP3 Vesicular Transport Assay - β-Estradiol 17-(β-D-glucuronide)
- MRP4 Vesicular Transport Assay
- MRP5 Vesicular Transport Assay
- MRP1 Vesicular Transport Assay - β-Estradiol 17-(β-D-glucuronide)
- MRP2 Vesicular Transport Assay - Coproporphyrin I
- BCRP Vesicular Transport Assay - MTX
- BCRP Vesicular Transport Assay - Rosuvastatin
- BCRP Vesicular Transport Assay - Uric acid
- MRP3 Vesicular Transporter Assay - Coproporphyrin I
- MRP1 Vesicular Transporter Assay - Estradiol-17β-D-glucuronide
- Bsep- Dog Vesicular Transporter Assay
- Bcrp1- Mouse Vesicular Transport Assay
- Bcrp- Rat Vesicular Transporter Assay- Estrone 3-sulfate
- Bsep- Mouse Vesicular Transport Assay
- Bsep- Rat Vesicular Transport Assay
- Bsep- Cynomolgus monkey Vesicular Transporter Assay
- Bcrp- Cynomolgus monkey Vesicular Transporter Assay
- Mdr1a- Mouse Vesicular Transport Assay
- Mdr1- Cynomolgus monkey Vesicular Transporter Assay
- Mdr1b- Rat Vesicular Transport Assay
- Mrp2 - Rat Vesicular Transport Assay
- Mrp3- Rat Vesicular Transport Assay
- BCRP Vesicular Transporter Assay - Sulfasalazine
- MDCKII Monolayer Assays
- MDCKII-BCRP - Prazosin
- MDCKII-BCRP - Chlorothiazide
- MDCKII-MDR1 - Quinidine
- MDCKII-MDR1 - Digoxin
- MDCKII-Bcrp1- Mouse
- MDCKII-OATP2B1/BCRP
- MDCKII-OCT2/MATE1 - Metformin
- MDCKII-OCT2/MATE1 - Tetraethylammonium chloride (TEA)
- MDCKII-OCT2/MATE2K - Metformin
- MDCKII-OCT2/MATE2K - Tetraethylammonium chloride (TEA)
- MDCKII-Mdr1- Cynomolgus monkey
- MDCKII-BCRP - Teriflunomide
- MDCKII-Bcrp- Cynomolgus monkey
- MDCKII-Bcrp- Rat
- Abcb1KO-MDCKII-MDR1 - Digoxin
- Abcb1KO-MDCKII-mouseMdr1a - Digoxin
- Abcb1KO-MDCKII-ratMdr1a - Digoxin
- Abcb1KO-MDCKII-cyMdr1 - Digoxin
- Caco-2 Transporter Knockout Cell-Based Assays
- Caco-2 BCRP substrate assessment / Transporter knockout
- Caco-2 MDR1 substrate assessment / Transporter knockout
- Caco-2 MRP2 substrate assessment / Transporter knockout
- Caco-2 MDR1/BCRP substrate assessment / Transporter double knockout
- Caco-2 MDR1/MRP2 substrate assessment / Transporter double knockout
- Caco-2 MRP2/BCRP substrate assessment / Transporter double knockout
- LLC-PK1 Monolayer Assays
- Uptake Transporter Services
- Uptake Transporter Assays
- ASBT Uptake Transporter Assay
- CNT1 Uptake Transporter Assay
- CNT2 Uptake Transporter Assay
- CNT3 Uptake Transporter Assay
- ENT1 Uptake Transporter Assay
- ENT2 Uptake Transporter Assay
- ENT4 Uptake Transporter Assay
- HPT1 Uptake Transporter Assay
- MATE1 Uptake Transporter Assay - Metformin
- MATE2-K Uptake Transporter Assay - Metformin
- NTCP Uptake Transporter Assay
- Ntcp- Cynomolgus monkey Uptake Transporter Assay
- Ntcp- Rat Uptake Transporter Assay
- OAT1 Uptake Transporter Assay - Para-Aminohippuric acid (PAH)
- OAT1 Uptake Transporter Assay - Tenofovir
- Oat1- Rat Uptake Transporter Assay
- OAT2v1 Uptake Transporter Assay - cGMP
- OAT3 Uptake Transporter Assay - Estrone 3-sulfate (E3S)
- Oatp1a1 - Rat Uptake Transporter Assay - Estrone 3-sulfate (E3S)
- OATP1A2 Uptake Transporter Assay
- Oatp1a4 - Rat Uptake Transporter Assay
- OATP2A1 Uptake Transporter Assay
- OATP1B1 Uptake Transporter Assay - Estrone 3-sulfate (E3S)
- Oatp1b1 - Cynomolgus monkey Uptake Transporter Assay - β-Estradiol 17-(β-D-glucuronide)
- Oatp1b2- Rat Uptake Transporter Assay
- OATP1B3 Uptake Transporter Assay - β-Estradiol 17-(β-D-glucuronide)
- Oatp1b3- Cynomolgus monkey Uptake Transporter Assay - CCK8
- OATP2B1 Uptake Transporter Assay - Estrone 3-sulfate (E3S)
- Oatp2b1- Cynomolgus monkey Uptake Transporter Assay
- OCT1 Uptake Transporter Assay - Metformin
- OCT2 Uptake Transporter Assay - Metformin
- OCT3 Uptake Transporter Assay
- OCTN1 Uptake Transporter Assay
- OCTN2 Uptake Transporter Assay
- Octn2- Rat Uptake Transporter Assay
- PEPT1 Uptake Transporter Assay
- PEPT2 Uptake Transporter Assay
- SGLT1 Uptake Transporter Assay
- SGLT2 Uptake Transporter Assay
- URAT1 Uptake Transporter Assay - Orotic acid
- Asbt-rat Uptake Transporter Assay
- OSTα/β Uptake Transporter Assay
- OSTα/β- Rat Uptake Transporter Assay
- MATE1 Uptake Transporter Assay - Tetraethylammonium chloride (TEA)
- MATE2-K Uptake Transporter Assay - Tetraethylammonium chloride (TEA)
- MCT10 Uptake Transporter Assay
- MCT8 Uptake Transporter Assay
- NIS Uptake Transporter Assay
- OAT1 Uptake Transporter Assay - Uric acid
- OAT2v1 Uptake Transporter Assay - Creatinine
- OAT2v1 Uptake Transporter Assay - Uric acid
- OAT3 Uptake Transporter Assay - Methotrexate (MTX)
- OAT3 Uptake Transporter Assay - Uric acid
- OAT4 Uptake Transporter Assay- Uric acid
- Oatp1a1 - Rat Uptake Transporter Assay - Taurocholate
- OATP1B1 Uptake Transporter Assay - Coproporphyrin I
- OATP1B1 Uptake Transporter Assay - Olmesartan
- OATP1B1 Uptake Transporter Assay - Rosuvastatin
- OATP1B1 Uptake Transporter Assay - β-Estradiol 17-(β-D-glucuronide)
- Oatp1b1- Cynomolgus monkey Uptake Transporter Assay - Estrone 3-sulfate (E3S)
- OATP1B3 Uptake Transporter Assay - CCK8
- OATP1B3 Uptake Transporter Assay - Coproporphyrin I
- OATP1B3 Uptake Transporter Assay - Coproporphyrin III
- OATP1B3 Uptake Transporter Assay - Fluo-3
- OATP1B3 Uptake Transporter Assay - Olmesartan
- OATP1B3 Uptake Transporter Assay - Rosuvastatin
- Oatp1b3- Cynomolgus monkey Uptake Transporter Assay - β-Estradiol 17-(β-D-glucuronide)
- OATP2B1 Uptake Transporter Assay - Coproporphyrin III
- OATP2B1 Uptake Transporter Assay - Rosuvastatin
- OCT1 Uptake Transporter Assay - Sumatriptan
- OCT1 Uptake Transporter Assay - Tetraethylammonium chloride (TEA)
- OCT2 Uptake Transporter Assay - Creatinine
- OCT2 Uptake Transporter Assay - MPP+
- OCT2 Uptake Transporter Assay - Tetraethylammonium chloride (TEA)
- URAT1 Uptake Transporter Assay - Uric acid
- SGLT6 Uptake Transporter Assay
- SGLT5 Uptake Transporter Assay
- OAT7 Uptake Transporter Assay
- LAT1 Uptake Transporter Assay
- LAT2 Uptake Transporter Assay
- THTR1 Uptake Transporter Assay
- THTR2 Uptake Transporter Assay
- Sglt2-dog Uptake Transporter Assay
- Sglt2-mouse Uptake Transporter Assay
- OAT4 Uptake Transporter Assay- Estrone-3-sulfate
- ASCT1 Uptake Transporter Assay- Serine
- ASCT2 Uptake Transporter Assay- Serine
- Nis - Rat Uptake Transporter Assay
- Ent1-Rat Uptake Transporter Assay
- RFVT3 Uptake Transporter Assay - Riboflavin
- Mate1 - cynomolgus monkey Uptake Transporter Assay
- Mate2 - cynomolgus monkey Uptake Transporter Assay
- Uptake Transporter Assays
Transporters
- Mate2 - cynomolgus monkey
- Mate1 - cynomolgus monkey
- RFVT3
- Ent1-rat
- Nis - rat
- Mrp3 - mouse
- Sglt2 - dog
- Sglt2 - mouse
- THTR2
- ASCT1
- SGLT5
- SGLT6
- THTR1
- SGLT4
- OAT7
- OAT4
- NIS
- MDR3
- MCT8
- MCT10
- LAT2
- LAT1
- ASCT2
- Ost α and β - rat
- Bsep - cynomolgus monkey
- Bsep - dog
- OST α and β
- Asbt - rat
- OAT2
- Bcrp - cynomolgus monkey
- Mdr1 - cynomolgus monkey
- ENT4
- SGLT2
- Mrp3 - rat
- Mdr1b - rat
- ENT2
- CNT3
- CNT2
- ENT1
- CNT1
- Ntcp - cynomolgus monkey
- Oatp2b1 - cynomolgus monkey
- Oatp1b3 -cynomolgus monkey
- Oatp1b1 - cynomolgus monkey
- Oatp1a4 - rat
- OATP2B1
- Oatp1b2 - rat
- SGLT1
- ASBT
- OCT3
- URAT1
- OATP1A2
- Octn2 - rat
- MATE2
- OATP2A1
- Mdr1a - mouse
- Bsep - rat
- Oat1 - rat
- HPT1
- Bcrp - rat
- OATP1B1
- OCTN2
- MATE1
- Mdr1a - rat
- Bcrp - mouse
- Mrp2 - rat
- Ntcp - rat
- Bsep - mouse
- BSEP
- OCT1
- OCT2
- OAT1
- BCRP
- MRP4
- OAT3
- NTCP
- Oatp1a1 - rat
- OCTN1
- PEPT2
- PEPT1
- OATP1B3
- MRP5
- MRP3
- MRP2
- MDR1/P-gp
- MRP1
Barriers
Technologies
- Renal Proximal Tubule Cell Monolayer Assay
- Sandwich-cultured hepatocyte services
- Hepatocyte Uptake Assay
- Monolayer Assay
- Uptake Transporter Assay
- Vesicular Transport Assay
- ATPase Assay
Recent Developments
Webinars
- Evolving Approaches on Measurements and Applications of Intracellular Free Drug Concentration and Kpuu in Drug Discovery
- MDR1 Promotes Intrinsic and Acquired Resistance to PROTACs in Cancer Cells – a Case Report
- Proteomics-informed Modeling Reveals Glucuronidation as a Transport Mechanism for Drugs and Endobiotics
- ICH M12 Draft Guidance on Drug Interaction Studies
- Gaining Mechanistic Insight in Drug Induced Cholestasis: What Can We Learn from Bile Acid Profiling in Human Hepatocytes?
- Assessing Drug Interactions Using Solute Carrier (SLC) Biomarkers: A Report from the Front Line
- Efflux Transporters – Challenges, Failures, and Success Stories
- Endogenous Biomarkers to Detect Transporter Drug-drug Interactions: the Recent Updates
- Breast Cancer Resistance Protein (BCRP)-Mediated Drug-Drug Interactions: Clinical Implications and Quantitative Risk Assessment
- ECCS Class 3A: Interaction of Gabapentin and its Analogues with Transporters – a love-hate relationship
- The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology
- Drug Transporters in Human Stem Cells
- Vitamin Transport in Clinical Toxicities: Folate and Neural Tube Birth Defects
- New Insights on Fat-Soluble Vitamin Efflux by the Intestine
- The Next Frontier in ADME Science: Predicting and Verifying Tissue Drug Exposure
- Validating and Optimizing In Vitro Assays for Improved DDI Prediction – assay calibration and time-dependent inhibition
- Using DILIsym to Predict Hepatotoxicity Risk During Pre-clinical Development
- Role of Organic Anionic Transporter (OAT2) in the Hepatic Clearance of Anionic/Zwitterionic Drugs – ‘A missing piece of the puzzle’
- Highlights of ITC3: Clinically-Relevant Transporters, Clinical Probes and DDI Evaluation
- Transporter-Enzyme and Transporter-Transporter Interplay in Predicting Drug Absorption and Disposition
- Rapid and accurate high-throughput in vitro prediction of nephrotoxicity in humans with ProxTox-HTS
- In Vitro PK Studies in a Long-Term Liver Model
- Natural Product-Drug Interactions: Case Studies from the NaPDI Center
- Application of sandwich-cultured hepatocytes and the B-Clear assay for the IVIVE of hepatic clearance, drug-drug interactions and unbound intracellular drug concentrations
- Sulfate Conjugates as Solute Carrier Transporter Substrates; Probes, Biomarkers, and Utility?
- Combining transporter data with quantitative systems toxicology modeling (DILIsym) to impact decisions in drug development
- The potential of engineered human liver co-cultures in phenotypic drug discovery for liver diseases
- The utility of microscale human liver co-cultures for investigating drug toxicity outcomes
- Using micropatterned co-cultures to model human-specific drug metabolism, disposition and drug-drug interactions
- Engineering Micropatterned Co-cultures for Drug Development
- The Promises of Quantitative Transporter Proteomics: IVIVE to Precision Medicine
- Understanding Hepatobiliary Disposition:The Importance of an Integrative Platform in Evaluating Transporter Interactions
- Predictive cross-species proximal tubule cell models for drug development and safety assessment studies
- Transporter-driven Vectorial Transport of Cationic, Anionic, and Zwitterionic Drugs in the Intestine
- Role of inhibition of the bile salt export pump (BSEP) in drug induced liver injury
- Imaging of ABC transporters at the blood-brain barrier with positron emission tomography
- Principles of Transporter Drug Interactions with Special Focus on Hepatic and BBB Transporters
- Managing Digoxin DDI by the P-gp IC50 working group & Practical methods to assess role of hepatic uptake transporters
Grants
- GINOP_PLUSZ-2.1.1-21-2022-00043
- 2019-1.1.1-PIACI-KFI-2019-00245
- GINOP-2.2.1-15-2017-00047
- GINOP-2.2.1-15-2016-00009
- GINOP-2.1.1-15-2016-00826
- TÁMOP-2.4.5-12/7-2012-0687
- TÁMOP-2.1.3.B-12/1-2012-0021
- IPARJOG-12-1-2013-0109
- IVDMDQ08
- GOP-1.3.1-11/B-2011-0036 projekt
- GOP-1.1.1-11-2011-0064 projekt
- GOP-1.1.1-11-2011-0017 projekt
- GOP-1.1.1-09/1-2009-0055 projekt
- GOP-1.1.1-09/1-2009-0054 projekt
- GOP-1.3.2-09-2010-0008 Projekt