Uptake Transporter Assays

Service Cell Line Transporter Technology Membrane Type Probe Substrate Read Out Reference Inhibitor Positive Control Dynamic Range
ASBT Uptake Transporter Assay ASBT
Uptake Transporter Assay
Taurocholic acid Fluvastatin
CNT1 Uptake Transporter Assay CNT1
Uptake Transporter Assay
Uridine Adenosine
CNT2 Uptake Transporter Assay CNT2
Uptake Transporter Assay
Uridine Adenosine
CNT3 Uptake Transporter Assay CNT3
Uptake Transporter Assay
Uridine Adenosine
ENT1 Uptake Transporter Assay ENT1
Uptake Transporter Assay
Uridine Dilazep
ENT2 Uptake Transporter Assay ENT2
Uptake Transporter Assay
Adenosine Dipyridamole
ENT4 Uptake Transporter Assay ENT4
Uptake Transporter Assay
MPP+ Pyrimethamine
HPT1 Uptake Transporter Assay HPT1
Uptake Transporter Assay
Gly-Sar Cefadroxil
MATE1 Uptake Transporter Assay MATE1
Uptake Transporter Assay
Tetraethylammonium-chloride (TEA), Metformin Quinidine
MATE2-K Uptake Transporter Assay MATE2
Uptake Transporter Assay
Tetraethylammonium-chloride (TEA), Metformin Pyrimethamine
NTCP Uptake Transporter Assay NTCP
Uptake Transporter Assay
Taurocholate TCDC
Ntcp - cynomolgus monkey Uptake Transporter Assay Ntcp - cynomolgus monkey
Uptake Transporter Assay
Taurocholate Troglitazone
Ntcp - Rat Uptake Transporter Assay Ntcp - rat
Uptake Transporter Assay
Taurocholate TCDC
OAT1 Uptake Transporter Assay OAT1
Uptake Transporter Assay
p-Aminohippuric acid (PAH), Tenofovir Benzbromarone, Probenecid
OAT1 Uptake Transporter Assay - probe substrate: tenofovir OAT1
Uptake Transporter Assay
p-Aminohippuric acid (PAH), Tenofovir Benzbromarone
Oat1 - rat Uptake Transporter Assay Oat1 - rat
Uptake Transporter Assay
p-Aminohippuric acid (PAH) Benzbromarone
OAT2v1 Uptake Transporter Assay OAT2
Uptake Transporter Assay
cGMP Indomethacin
OAT3 Uptake Transporter Assay OAT3
Uptake Transporter Assay
Estrone-3-Sulfate (E3S), Methotrexate Probenecid
Oatp1a1 - Rat Uptake Transporter Assay Oatp1a1 - rat
Uptake Transporter Assay
Estrone-3-Sulfate (E3S) Ketoconazole
OATP1A2 Uptake Transporter Assay OATP1A2
Uptake Transporter Assay
Estrone-3-Sulfate (E3S) Sulfobromophthalein (BSP)
Oatp1a4 - rat Uptake Transporter Assay Oatp1a4 - rat
Uptake Transporter Assay
Taurocholic acid Rifampicin
OATP2A1 Uptake Transporter Assay OATP2A1
Uptake Transporter Assay
Prostaglandin-E2 Diclofenac
OATP1B1 Uptake Transporter Assay OATP1B1
Uptake Transporter Assay
Estrone-3-Sulfate (E3S), Estradiol-17-β-glucuronide (E217βG) Cerivastatin, Rifampicin
Oatp1b1 - monkey Uptake Transporter Assay Oatp1b1 - cynomolgus monkey
Uptake Transporter Assay
E3S Cyclosporin A
Oatp1b2 - rat Uptake Transporter Assay Oatp1b2 - rat
Uptake Transporter Assay
Taurocholate Fluvastatin
OATP1B3 Uptake Transporter Assay OATP1B3
Uptake Transporter Assay
CCK-8 Rifampicin
Oatp1b3 - monkey Uptake Transporter Assay Oatp1b3 -cynomolgus monkey
Uptake Transporter Assay
E217βG/CCK-8 Cyclosporin A
OATP2B1 Uptake Transporter Assay OATP2B1
Uptake Transporter Assay
Estrone-3-Sulfate (E3S) Fluvastatin
Oatp2b1 - cynomolgus monkey Uptake Transporter Assay Oatp2b1 - cynomolgus monkey
Uptake Transporter Assay
E3S Sulfasalazine
OCT1 Uptake Transporter Assay OCT1
Uptake Transporter Assay
Tetraethylammonium-chloride (TEA), Metformin, MPP+ Verapamil
OCT2 Uptake Transporter Assay OCT2
Uptake Transporter Assay
Tetraethylammonium-chloride (TEA), Metformin, MPP+ Verapamil, Quinine
OCT3 Uptake Transporter Assay OCT3
Uptake Transporter Assay
MPP+ Quinidine
OCTN1 Uptake Transporter Assay OCTN1
Uptake Transporter Assay
Tetraethylammonium-chloride (TEA) Verapamil
OCTN2 Uptake Transporter Assay OCTN2
Uptake Transporter Assay
Carnitine Verapamil
Octn2-rat Uptake Transporter Assay Octn2 - rat
Uptake Transporter Assay
Carnitine Verapamil
PEPT1 Uptake Transporter Assay PEPT1
Uptake Transporter Assay
Gly-Sar Tyr-Phe
PEPT2 Uptake Transporter Assay PEPT2
Uptake Transporter Assay
Gly-Sar Cefadroxil
SGLT1 Uptake Transporter Assay SGLT1
Uptake Transporter Assay
methyl-a-D-glucopyranoside Phloridzin
SGLT2 Uptake Transporter Assay SGLT2
Uptake Transporter Assay
methyl-a-D-glucopyranoside Dapagliflozin
URAT1 Uptake Transporter Assay URAT1
Uptake Transporter Assay
Uric acid, Orotic acid Benzbromarone
Asbt-rat Uptake Transporter Assay Asbt - rat
Uptake Transporter Assay
OST alpha and beta Uptake Transporter Assay OST alpha and beta
Uptake Transporter Assay
Ost alpha and beta-rat Uptake Transporter Assay Ost alpha and beta - rat
Uptake Transporter Assay

Description

SOLVO provides two types of uptake transporter studies: inhibition assessment, and substrate assessment. Both are suitable for drug-drug interaction studies: the inhibition (indirect) assays use predefined uptake transporter substrates for this purpose, while the substrate (direct) assays can be designed to test the drug-drug interaction of the client’s test article with any potential perpetrator compound.

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Learn more about our uptake transporter assay services.

Learn more about our uptake transporter assay technology.