Uptake Transporter Assays

Service Cell Line Transporter Technology Membrane Type Probe Substrate Read Out Reference Inhibitor Positive Control Dynamic Range
Asbt-rat Uptake Transporter Assay Asbt - rat
Uptake Transporter Assay
Taurocholate Taurochenodeoxycholate (TCDC)
ASBT Uptake Transporter Assay ASBT
Uptake Transporter Assay
Taurocholate Taurochenodeoxycholate (TCDC), Fluvastatin
CNT1 Uptake Transporter Assay CNT1
Uptake Transporter Assay
Uridine Adenosine
CNT2 Uptake Transporter Assay CNT2
Uptake Transporter Assay
Uridine Adenosine
CNT3 Uptake Transporter Assay CNT3
Uptake Transporter Assay
Uridine 2′-Deoxycytidine
ENT1 Uptake Transporter Assay ENT1
Uptake Transporter Assay
Uridine Dilazep
ENT2 Uptake Transporter Assay ENT2
Uptake Transporter Assay
Adenosine Dipyridamole
ENT4 Uptake Transporter Assay ENT4
Uptake Transporter Assay
MPP+ Pyrimethamine
HPT1 Uptake Transporter Assay HPT1
Uptake Transporter Assay
Gly-Sar Cefadroxil
MATE1 Uptake Transporter Assay - Metformin MATE1
Uptake Transporter Assay
Metformin Quinidine, Pyrimethamine
MATE1 Uptake Transporter Assay - Tetraethylammonium chloride (TEA) MATE1
Uptake Transporter Assay
Tetraethylammonium chloride (TEA) Quinidine, Pyrimethamine
MATE2-K Uptake Transporter Assay - Metformin MATE2
Uptake Transporter Assay
Metformin Pyrimethamine
MATE2-K Uptake Transporter Assay - Tetraethylammonium chloride (TEA) MATE2
Uptake Transporter Assay
Tetraethylammonium chloride (TEA) Pyrimethamine
MCT10 Uptake Transporter Assay MCT10
Uptake Transporter Assay
Triiodothyronine (T3) Imatinib mesylate
MCT8 Uptake Transporter Assay MCT8
Uptake Transporter Assay
Triiodothyronine (T3) Sorafenib
NIS Uptake Transporter Assay NIS
Uptake Transporter Assay
Iodide Potassium perchlorate
Ntcp- Cynomolgus monkey Uptake Transporter Assay Ntcp - cynomolgus monkey
Uptake Transporter Assay
Taurocholate Taurochenodeoxycholate (TCDC)
Ntcp- Rat Uptake Transporter Assay Ntcp - rat
Uptake Transporter Assay
Taurocholate Taurochenodeoxycholate (TCDC), Troglitazone
NTCP Uptake Transporter Assay NTCP
Uptake Transporter Assay
Taurocholate Taurochenodeoxycholate (TCDC)
Oat1- Rat Uptake Transporter Assay Oat1 - rat
Uptake Transporter Assay
p-Aminohippuric acid (PAH) Benzbromarone
OAT1 Uptake Transporter Assay - Para-Aminohippuric acid (PAH) OAT1
Uptake Transporter Assay
p-Aminohippuric acid (PAH) Benzbromarone
OAT1 Uptake Transporter Assay - Tenofovir OAT1
Uptake Transporter Assay
Tenofovir Probenecid
OAT1 Uptake Transporter Assay - Uric acid OAT1
Uptake Transporter Assay
Uric acid Benzbromarone
OAT2v1 Uptake Transporter Assay - cGMP OAT2
Uptake Transporter Assay
cGMP Indomethacin
OAT2v1 Uptake Transporter Assay - Creatinine OAT2
Uptake Transporter Assay
Creatinine Indomethacin
OAT2v1 Uptake Transporter Assay - Uric acid OAT2
Uptake Transporter Assay
Uric acid Indomethacin
OAT3 Uptake Transporter Assay - Estrone 3-sulfate (E3S) OAT3
Uptake Transporter Assay
Estrone-3-Sulfate (E3S) Probenecid
OAT3 Uptake Transporter Assay - Methotrexate (MTX) OAT3
Uptake Transporter Assay
Methotrexate (MTX) Probenecid
OAT3 Uptake Transporter Assay - Uric acid OAT3
Uptake Transporter Assay
Uric acid Benzbromarone
OAT4 Uptake Transporter Assay OAT4
Uptake Transporter Assay
Uric acid Benzbromarone
Oatp1a1 - Rat Uptake Transporter Assay - Estrone 3-sulfate (E3S) Oatp1a1 - rat
Uptake Transporter Assay
Estrone-3-Sulfate (E3S) Ketoconazole, Dehydroisoandrosterone 3-sulfate
Oatp1a1 - Rat Uptake Transporter Assay - Taurocholate Oatp1a1 - rat
Uptake Transporter Assay
Taurocholate Dehydroisoandrosterone 3-sulfate
OATP1A2 Uptake Transporter Assay OATP1A2
Uptake Transporter Assay
Estrone-3-Sulfate (E3S) Sulfobromophthalein (BSP)
Oatp1a4 - Rat Uptake Transporter Assay Oatp1a4 - rat
Uptake Transporter Assay
Taurocholate Rifampicin
Oatp1b1- Cynomolgus monkey Uptake Transporter Assay - Estrone 3-sulfate (E3S) Oatp1b1 - cynomolgus monkey
Uptake Transporter Assay
Estrone 3-sulfate (E3S) Fluvastatin
Oatp1b1 - Cynomolgus monkey Uptake Transporter Assay - β-Estradiol 17-(β-D-glucuronide) Oatp1b1 - cynomolgus monkey
Uptake Transporter Assay
β-Estradiol 17-(β-D-glucuronide) Rifampicin
OATP1B1 Uptake Transporter Assay - Estrone 3-sulfate (E3S) OATP1B1
Uptake Transporter Assay
Estrone-3-Sulfate (E3S) Cerivastatin, Cyclosporin A
OATP1B1 Uptake Transporter Assay - Coproporphyrin I OATP1B1
Uptake Transporter Assay
Coproporphyrin I Rifampicin
OATP1B1 Uptake Transporter Assay - β-Estradiol 17-(β-D-glucuronide) OATP1B1
Uptake Transporter Assay
β-Estradiol 17-(β-D-glucuronide) Rifampicin
OATP1B1 Uptake Transporter Assay - Olmesartan OATP1B1
Uptake Transporter Assay
Olmesartan Rifampicin
OATP1B1 Uptake Transporter Assay - Rosuvastatin OATP1B1
Uptake Transporter Assay
Rosuvastatin Rifampicin
Oatp1b2- Rat Uptake Transporter Assay Oatp1b2 - rat
Uptake Transporter Assay
Taurocholate Taurochenodeoxycholate (TCDC)
Oatp1b3- Cynomolgus monkey Uptake Transporter Assay - β-Estradiol 17-(β-D-glucuronide) Oatp1b3 -cynomolgus monkey
Uptake Transporter Assay
β-Estradiol 17-(β-D-glucuronide) Cyclosporin A
Oatp1b3- Cynomolgus monkey Uptake Transporter Assay - CCK8 Oatp1b3 -cynomolgus monkey
Uptake Transporter Assay
CCK8 Cyclosporin A
OATP1B3 Uptake Transporter Assay - CCK8 OATP1B3
Uptake Transporter Assay
CCK8 Rifampicin
OATP1B3 Uptake Transporter Assay - Coproporphyrin I OATP1B3
Uptake Transporter Assay
Coproporphyrin I Rifampicin
OATP1B3 Uptake Transporter Assay - Coproporphyrin III OATP1B3
Uptake Transporter Assay
Coproporphyrin III Rifampicin
OATP1B3 Uptake Transporter Assay - Fluo-3 OATP1B3
Uptake Transporter Assay
Fluo-3 Fluvastatin
OATP1B3 Uptake Transporter Assay - Olmesartan OATP1B3
Uptake Transporter Assay
Olmesartan Rifampicin
OATP1B3 Uptake Transporter Assay - Rosuvastatin OATP1B3
Uptake Transporter Assay
Rosuvastatin Cyclosporin A
OATP1B3 Uptake Transporter Assay - β-Estradiol 17-(β-D-glucuronide) OATP1B3
Uptake Transporter Assay
β-Estradiol 17-(β-D-glucuronide) Cyclosporin A, Rifampicin
OATP2A1 Uptake Transporter Assay OATP2A1
Uptake Transporter Assay
Prostaglandin-E2 Diclofenac
Oatp2b1- Cynomolgus monkey Uptake Transporter Assay Oatp2b1 - cynomolgus monkey
Uptake Transporter Assay
Estrone 3-sulfate (E3S) Sulfasalazine
OATP2B1 Uptake Transporter Assay - Estrone 3-sulfate (E3S) OATP2B1
Uptake Transporter Assay
Estrone-3-Sulfate (E3S) Fluvastatin, Rifamycin SV
OATP2B1 Uptake Transporter Assay - Coproporphyrin III OATP2B1
Uptake Transporter Assay
Coproporphyrin III Erlotinib
OATP2B1 Uptake Transporter Assay - Rosuvastatin OATP2B1
Uptake Transporter Assay
Rosuvastatin Erlotinib
OCT1 Uptake Transporter Assay - Metformin OCT1
Uptake Transporter Assay
Metformin Verapamil
OCT1 Uptake Transporter Assay - Sumatriptan OCT1
Uptake Transporter Assay
Sumatriptan Verapamil
OCT1 Uptake Transporter Assay - Tetraethylammonium chloride (TEA) OCT1
Uptake Transporter Assay
Tetraethylammonium chloride (TEA) Verapamil
OCT2 Uptake Transporter Assay - Metformin OCT2
Uptake Transporter Assay
Metformin Verapamil
OCT2 Uptake Transporter Assay - Creatinine OCT2
Uptake Transporter Assay
Creatinine Verapamil
OCT2 Uptake Transporter Assay - MPP+ OCT2
Uptake Transporter Assay
MPP+ Phenoxybenzamine
OCT2 Uptake Transporter Assay - Tetraethylammonium chloride (TEA) OCT2
Uptake Transporter Assay
Tetraethylammonium chloride (TEA) Verapamil
OCT3 Uptake Transporter Assay OCT3
Uptake Transporter Assay
MPP+ Quinidine
OCTN1 Uptake Transporter Assay OCTN1
Uptake Transporter Assay
Tetraethylammonium-chloride (TEA) Verapamil
Octn2- Rat Uptake Transporter Assay Octn2 - rat
Uptake Transporter Assay
Carnitine Verapamil
OCTN2 Uptake Transporter Assay OCTN2
Uptake Transporter Assay
Carnitine Verapamil
OSTα/β- Rat Uptake Transporter Assay Ost alpha and beta - rat
Uptake Transporter Assay
Estrone 3-sulfate (E3S) Ko143
OSTα/β Uptake Transporter Assay OST alpha and beta
Uptake Transporter Assay
Estrone 3-sulfate (E3S) Ko143
PEPT1 Uptake Transporter Assay PEPT1
Uptake Transporter Assay
Gly-Sar Tyr-Phe
PEPT2 Uptake Transporter Assay PEPT2
Uptake Transporter Assay
Gly-Sar Cefadroxil
SGLT1 Uptake Transporter Assay SGLT1
Uptake Transporter Assay
methyl-α-D-glucopyranoside Phloridzin
SGLT2 Uptake Transporter Assay SGLT2
Uptake Transporter Assay
methyl-α-D-glucopyranoside Dapagliflozin
SGLT5 Uptake Transporter Assay SGLT5
Uptake Transporter Assay
Fructose Dapagliflozin
SGLT6 Uptake Transporter Assay SGLT6
Uptake Transporter Assay
myo-Inositol Dapagliflozin
URAT1 Uptake Transporter Assay - Orotic acid URAT1
Uptake Transporter Assay
Orotic acid Benzbromarone
URAT1 Uptake Transporter Assay - Uric acid URAT1
Uptake Transporter Assay
Uric acid Benzbromarone

Description

SOLVO provides two types of uptake transporter studies: inhibition assessment, and substrate assessment. Both are suitable for drug-drug interaction studies: the inhibition (indirect) assays use predefined uptake transporter substrates for this purpose, while the substrate (direct) assays can be designed to test the drug-drug interaction of the client’s test article with any potential perpetrator compound.

#Check for availability.

Learn more about our uptake transporter assay services.

Learn more about our uptake transporter assay technology.