1. Lysosomal Trapping Measurement in Multiple Cell Types Using High Content Screening System
  2. Adaptation of In vitro Methods to Determine Unbound Cell to Medium Partition Coefficient, Kp,uu


  1. Comparative Hepatic Uptake Studies Using Suspension and Plated Hepatocyte Cultures Originating from Human and Preclinical Species
  2. A Novel In Vitro Tool for Testing Drug Interactions of Human MDR3 Transporter


  1. Teriflunomide, a Specific BCRP (ABCG2) Probe
  2. Predictive Value of Coproporphyrin I Compared to E217bG for OATP1B1-Mediated Drug-drug Interactions
  3. Assay Calibration to Refine Prediction of OATP1B1/1B3 Mediated Drug-drug Interactions (DDI) Based on In Vitro Uptake Transport Assay Data
  4. Correlation of BCRP kinetic transport and inhibitory potential parameters for different probe substrates in vesicular transport experiments using different expression systems
  5. Comparison of the transport of sulfated and non-sulfated bile salts by rat and human Mrp2/MRP2 and Bsep/BSEP transporters
  6. Characterization of GCDC transport by human hepatic uptake transporters for in vitro testing purposes
  7. Correlation Analysis of Potential BCRP Probes in Different Monolayer Systems
  8. In vitro tools to investigate creatine transport inhibition


  1. Evaluation of an Experimental Method for Ki Determination in Transporter Assays
  2. Tolcapone is a substrate of BCRP
  3. Time-Dependent Inhibition Demonstrated Across Multiple Classes of Uptake Transporters
  4. A systematic in vitro investigation of the preincubation effect on the inhibition of multiple uptake transporter families
  5. Rapid and Accurate High Throughput In Vitro Prediction of Nephrotoxicity in Humans with ProxTox HTS
  6. In vitro Evaluation of Hepatotoxicity by Amiodarone in Micropatterned Cocultured Hepatocytes (HepatoPac) using Liver-specific Biomarkers
  7. A systematic in vitro investigation of the inhibitor preincubation effect on multiple classes of clinically relevant transporters*


  1. Characterization of the specific interaction between BCRP (ABCG2/MXR) transporter and tolcapone
  2. Evaluation of Dabigatran etexilate as a potential new in vitro P-gp substrate
  3. Comparative study of enzyme kinetic parameters in different expression systems using relevant BCRP (ABCG2) probe substrates
  4. Assay calibration to refine prediction of P-gp mediated DDI based on in vitro vesicular transport assay data


  1. aProximate™ Human Primary Proximal Tubule Cell Monolayers as a Novel Predictive Model of Nephrotoxicity
  2. Ortholog identification of human, monkey and rat members of the OATP1 family in the liver
  3. Searching for specific and clinically relevant BCRP (ABCG2) probe
  4. In vitro evaluation of OATP1B1- and OATP1B3-mediated drug-drug interactions using statins as probe substrates
  5. Complementary in vitro tools to investigate renal drug transport
  6. Comparison of Inhibition Potency of Thirty-one Marketed Drugs Towards BSEP in Insect (Sf9) vs. Mammalian Based (HEK293) Cell Vesicles
  7. aProximate™ as a novel predictive model of polymyxin B and gentamicin induced nephrotoxicity


  1. Pre-plated Cell Lines to Address Membrane Transport Related Questions in the Pharmaceutical Industry

Before 2015

  1. Seliciclib (R-Roscovitine) is a selective ABCB1 substrate
  2. Multidrug resistance testing with in vitro ABC transporter assay
  3. Development of High-throughput Human OCT2 Expressing Uptake Assay System
  4. Mouse Bsep ATPase assay - a non-radioactive tool for assessment of the cholestatic potential of drug
  5. MRP2-mediated E217βG transport potentiation: in vitro - in vivo correlation and species specificity
  6. Kinetic characterization of sulfasalazine transport by ABCG2
  7. Passive permeability is a crucial parameter in choosing the right assay to detect the interaction of compounds with ABCB1 (Pgp) and ABCG2 (BCRP)
  8. Comparison of cell based and membrane based high throughput assays for the detection of drugs interacting with the BCRP transporter
  9. Comparative Analysis of Human Multidrug Resistance-Associated Protein 2 (MRP2) and Rat Mrp2
  10. Characterization of the interactions between BCRP (ABCG2/MXR) transporter and DMARDs; sulfasalazine, leflunomide and methotrexate
  11. Excipients may modulate the pathways in ADME/Tox via ABC-transporters
  12. Carry and Cramp - Cyclodextrins with dual function
  13. Interaction of quercetin and its metabolites with the transporter ABCC2 (cMOAT, MRP2)
  14. Chloroacetanilide herbicides and their metabolites interact with human Efflux Transporters and modulate drug absorption
  15. Interaction of Pesticides with human Efflux Transporters
  16. Laboratory validation and multicenter performance evaluation of the Solvo MDQ-Kit
  17. Chlorothiazide is an OAT1, OAT3 and BCRP substrate - implications in renal secretion of chlorothiazide
  18. Effect of PSC-833 (Valspodar) on the intestinal absorption of digoxin in mouse and rat, using different in vivo and ex vivo methods
  19. Revised approach in assessing Bsep-Cyclosporin A interactions in bile duct cannulated rats
  20. Optimization of cellular uptake assays for the determination of test compound interactions with OAT1 (SLC22A6)
  21. Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3