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Take home messages from the ITC papers

The potential for drug-drug interactions (DDIs) involving membrane transporters has become an area of intense regulatory review over the past seven years.

Regulatory Guidance for Drug Interaction Studies

SOLVO Transporter Studies for Regulatory Submission. Regulatory Requirements. SOLVO solutions and capabilities. Transporter Decision Trees.

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Webinar - ECCS Class 3A: Interaction of Gabapentin and its Analogues with Transporters – a Love-hate Relationship 2021, 28 January

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Transporters A-Z

Human Transporters

ASBT
ASCT2 Under Development
BCRP
BSEP
CNT1
CNT2
CNT3
ENT1
ENT2
ENT4
HPT1
LAT1 New
LAT2 Under Development
MATE1
MATE2
MCT10 New
MCT8 New
MDR1/P-gp
MDR3 Under Development
MRP1
MRP2
MRP3
MRP4
MRP5
NIS New
NTCP
OAT1
OAT2
OAT3
OAT4 New
OAT7 Under Development
OATP1A2
OATP1B1
OATP1B3
OATP2A1
OATP2B1
OCT1
OCT2
OCT3
OCTN1
OCTN2
OST alpha and beta
PEPT1
PEPT2
SGLT1
SGLT2
SGLT5 New
SGLT6 New
THTR1 and THTR2 New
URAT1

Preclinical/Animal Transporters

Asbt - rat
Bcrp - cynomolgus monkey
Bcrp - mouse
Bcrp - rat
Bsep - cynomolgus monkey
Bsep - dog
Bsep - mouse
Bsep - rat
Mdr1 - cynomolgus monkey
Mdr1a - mouse
Mdr1a - rat
Mdr1b - rat
Mrp2 - rat
Mrp3 - rat
Ntcp - cynomolgus monkey
Ntcp - rat
Oat1 - rat
Oatp1a1 - rat
Oatp1a4 - rat
Oatp1b1 - cynomolgus monkey
Oatp1b2 - rat
Oatp1b3 -cynomolgus monkey
Oatp2b1 - cynomolgus monkey
Octn2 - rat
Ost alpha and beta - rat

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