dogSglt2 is the ortholog of human SGLT2 and available in SOLVO’s portfolio. Functionality of the dog and human transporter are largely overlapping, although difference may exist in kinetics and IC50 values. Cell lines overexpressing pre-clinical species orthologs of human transporters can be used to assessing species-differences in compound handling.
Click here to read more about the human SGLT2 or request data on the assay characterization from our team.