Peer Reviewed Publications


09/15/2021 - Miscellaneous New

Modulation of Urate Transport by Drugs arrow_forward


09/15/2021 - Role of transporters in drug ADME New

Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics arrow_forward


06/01/2021 - Role of transporters in drug toxicity New

Quantitative Investigation of Irinotecan Metabolism, Transport and Gut Microbiome Activation arrow_forward


10/09/2020 - Role of transporters in drug ADME

Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models arrow_forward


09/13/2020 - Role of transporters in drug ADME

Inhibition of ABCG2/BCRP-mediated Transport-correlation Analysis of Various Expression Systems and Probe Substrates arrow_forward


08/17/2020 - Role of transporters in drug ADME

Pitfalls in Predicting Hepatobiliary Drug Transport Using Human Sandwich-Cultured Hepatocytes arrow_forward


07/11/2020 - Reviews

Prediction of Drug-Induced Hyperbilirubinemia by In Vitro Testing arrow_forward


06/25/2020 - Miscellaneous

Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake of Glucuronide Metabolites of Androgens arrow_forward


03/09/2020 - Role of transporters in drug ADME

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters arrow_forward


07/30/2019 - Reviews

Age-Related Functional and Expressional Changes in Efflux Pathways at the Blood-Brain Barrier arrow_forward


05/08/2019 - Role of transporters in drug ADME

A Systematic In Vitro Investigation of the Inhibitor Preincubation Effect on Multiple Classes of Clinically Relevant Transporters arrow_forward


04/05/2019 - Role of transporters in drug ADME

Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney arrow_forward


03/16/2019 - Reviews

ABCG2/BCRP: variants, transporter interaction profile of substrates and inhibitors arrow_forward


02/06/2019 - Role of transporters in drug ADME

Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics arrow_forward


02/04/2019 - Role of transporters in drug ADME

Involvement of Renal Efflux Transporter MATE1 in Renal Excretion of Flecainide arrow_forward


02/01/2019 - Role of transporters in drug toxicity

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury arrow_forward


10/23/2018 - Role of transporters in drug ADME

Determination of Reference Values of MDR-ABC Transporter Activities in CD3+ Lymphocytes of Healthy Volunteers Using a Flow Cytometry Based Method arrow_forward


09/12/2018 - Role of transporters in drug ADME

Inhibitor selectivity of CNTs and ENTs arrow_forward


08/15/2018 - Miscellaneous

The oncomir face of microRNA-206: A permanent miR-206 transfection study arrow_forward


07/25/2018 - Role of transporters in drug ADME

Correlation Analysis of Potential Breast Cancer Resistance Protein Probes in Different Monolayer Systems arrow_forward


07/06/2018 - Role of transporters in drug ADME

Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2 arrow_forward


06/19/2018 - Role of transporters in drug toxicity

Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency arrow_forward


06/11/2018 - Role of transporters in drug toxicity

Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides arrow_forward


06/05/2018 - Miscellaneous

Third-generation Sequencing Reveals Extensive Polycistronism and Transcriptional Overlapping in a Baculovirus arrow_forward


03/30/2018 - Role of transporters in drug ADME

Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001 arrow_forward


10/30/2017 - Role of transporters in drug ADME

Successful prediction of in vivo hepatobiliary clearances and hepatic concentrations of rosuvastatin using sandwich-cultured rat hepatocytes, transporter-expressing cell lines, and quantitative proteo arrow_forward


10/09/2017 - Role of transporters in drug toxicity

Kinetic characterization of bile salt transport by human NTCP (SLC10A1) arrow_forward


08/26/2017 - Miscellaneous

Species specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2) arrow_forward


07/26/2017 - Miscellaneous

First cloned human immortalized adipose derived mesenchymal stem-cell line with chimeric SS18-SSX1 gene (SS-iASC) arrow_forward


07/24/2017 - Miscellaneous

Optimization and Application of a Biotinylation Method for Quantification of Plasma Membrane Expression of Transporters in Cells arrow_forward


06/16/2017 - Role of transporters in drug ADME

Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice. arrow_forward


05/04/2017 - Miscellaneous

Repeated-dose toxicity of common ragweed on rats arrow_forward


01/01/2016 - Reviews

Investigating ABCB1-Mediated Drug-Drug Interactions: Considerations for In vitro and In vivo Assay Design arrow_forward


01/01/2016 - Reviews

Membrane Transporters in Physiological Barriers of Pharmacological Importance arrow_forward


03/05/2015 - Reviews

MDR-ABC transporters: biomarkers in rheumatoid arthritis arrow_forward


01/04/2015 - Role of transporters in drug ADME

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions arrow_forward


01/01/2015 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Multiple ABC Transporters Efflux Baicalin arrow_forward


01/01/2015 - Role of transporters in drug ADME

Membrane Assays to Characterize Interaction of Drugs with ABCB1 arrow_forward


01/01/2015 - Reviews

Mechanisms and therapeutic potential of inhibiting drug efflux transporters arrow_forward


01/01/2015 - Reviews

Pre-Plated Cell Lines for ADMETox Applications in the Pharmaceutical Industry arrow_forward


09/09/2014 - Miscellaneous

mRNA levels of related Abcb genes change opposite to each other upon histone deacetylase inhibition in drug-resistant rat hepatoma cells arrow_forward


05/04/2014 - Reviews

In vitro methods in drug transporter interaction assessment arrow_forward


03/05/2014 - Role of transporters in drug ADME

A P-gp vesicular transport inhibition assay - optimization and validation for drug-drug interaction testing arrow_forward


01/01/2014 - Role of transporters in drug ADME

Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes arrow_forward


01/01/2014 - Reviews

Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics arrow_forward


09/03/2013 - Reviews

Drug-transporter interaction testing in drug discovery and development arrow_forward


05/11/2013 - Role of transporters in drug ADME

ABCG2 modulates chlorothiazide permeability—in vitro-characterization of its interactions arrow_forward


01/09/2013 - Role of transporters in drug ADME

Synthesis and ABCG2 inhibitory activity of novel fumitremorgin C analogs—specificity and structure activity correlations arrow_forward


01/05/2013 - Role of transporters in drug ADME

Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3 arrow_forward


01/01/2013 - Role of transporters in drug ADME

Prediction of Therapy Response and Prognosis in Leukemias by Flow Cytometric MDR Assays arrow_forward


01/01/2013 - Role of transporters in drug ADME

The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier arrow_forward


12/05/2012 - Role of transporters in drug ADME

Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences arrow_forward


06/11/2012 - Role of transporters in drug toxicity

BSEP inhibition – in vitro screens to assess cholestatic potential of drugs. arrow_forward


05/08/2012 - Role of transporters in drug ADME

Digoxin is not a Substrate for Organic Anion Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a Substrate for a Sodium Dependent Transporter Expressed in HEK293 Cell arrow_forward


01/06/2012 - Role of transporters in drug ADME

Interactions of bilastine, a new oral H₁ antihistamine, with human transporter systems arrow_forward


01/04/2012 - Reviews

Efflux transporters in the blood-brain interfaces—in vitro and in vivo methods and correlations arrow_forward


01/01/2012 - Role of transporters in drug ADME

The vesicular transport assay: validated in vitro methods to study drug-mediated inhibition of canalicular efflux transporters ABCB11/BSEP and ABCC2/MRP2 arrow_forward


01/01/2012 - Role of transporters in drug ADME

The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related arrow_forward


01/01/2012 - Role of transporters in drug ADME

Verification of brain penetration of the unbound fraction of a novel HER2/EGFR dual kinase inhibitor (TAK-285) by microdialysis in rats arrow_forward


10/08/2011 - Role of transporters in drug ADME

Quinidine as an ABCB1 probe for testing drug interactions at the blood-brain barrier: an in vitro in vivo correlation study arrow_forward


09/06/2011 - Role of transporters in drug ADME

Calcein assay: a high-throughput method to assess P-gp inhibition arrow_forward


05/12/2011 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters arrow_forward


01/12/2011 - Role of transporters in drug ADME

Specific inhibition of the ABCG2 transporter could improve the efficacy of photodynamic therapy arrow_forward


01/12/2011 - Role of transporters in drug ADME

Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells arrow_forward


01/01/2011 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Ivermectin interacts with human ABCG2. arrow_forward


10/08/2010 - Role of transporters in drug ADME

ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor arrow_forward


07/12/2010 - Role of transporters in drug ADME

MRP2-mediated E2-17βG transport potentiation: in vitro - in vivo correlation and species specificity arrow_forward


05/11/2010 - Role of transporters in drug ADME

Comparison of 3 Assay Systems Using a Common Probe Substrate, Calcein AM, for Studying P-gp Using a Selected Set of Compounds arrow_forward


05/08/2010 - Role of transporters in drug ADME

A novel screening strategy to identify ABCB1 substrates and inhibitors arrow_forward


01/08/2010 - Reviews

ABCC2/Abcc2: a multispecific transporter with dominant excretory functions arrow_forward


12/12/2009 - Reviews

Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays arrow_forward


12/09/2009 - Miscellaneous

Characterisation of a GroEL Single-Ring Mutant that Supports Growth of Escherichia coli and Has GroES-Dependent ATPase Activity arrow_forward


11/06/2009 - Role of transporters in drug toxicity

Effect of membrane cholesterol on BSEP/Bsep activity - species specificity studies for substrates and inhibitors arrow_forward


09/11/2009 - Role of transporters in drug toxicity

Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs arrow_forward


09/04/2009 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Mechanistic study on the intestinal absorption and disposition of baicalein arrow_forward


06/05/2009 - Role of transporters in drug ADME

ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions arrow_forward


06/03/2009 - Role of transporters in drug ADME

Characterization of 5(6)-carboxy-2,‘7’-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4 arrow_forward


05/08/2009 - Role of transporters in drug ADME

Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes arrow_forward


02/03/2009 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Specific interactions of chloroacetanilide herbicides with human ABC transporter proteins arrow_forward


01/12/2009 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1 arrow_forward


01/11/2009 - Reviews

Potentiation of MRP2/Mrp2-mediated estradiol-17beta-glucuronide transport by drugs—a concise review arrow_forward


01/03/2009 - Role of transporters in drug ADME

Kinetic characterization of sulfasalazine transport by human ABCG2 (BCRP) arrow_forward


01/03/2009 - Reviews

Interaction of macrocyclic lactones with the multidrug transporters: the bases of the pharmacokinetics of lipid-like drugs arrow_forward


01/01/2009

Kinetic characterization of sulfasalazine transport by human ATP-binding cassette G2 arrow_forward


01/01/2009 - Role of transporters in drug ADME

Multidrug resistance protein 2-mediated estradiol-17beta-D-glucuronide transport potentiation: in vitro-in vivo correlation and species specificity arrow_forward


08/04/2008 - Role of transporters in drug ADME

Leflunomide and A771726, its metabolite are high affinity substrates of BCRP - implications for drug resistance arrow_forward


01/06/2008 - Reviews

Utilization of membrane vesicle preparations to study drug-ABC transporter interactions arrow_forward


08/03/2007 - Role of transporters in drug ADME

Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2 arrow_forward


03/10/2007 - Role of transporters in drug ADME

Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp) arrow_forward


03/05/2007 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2) arrow_forward


01/01/2007 - Role of transporters in drug ADME

In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions arrow_forward


01/01/2007 - Role of transporters in drug ADME

[In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions] arrow_forward


06/07/2006 - Role of transporters in drug ADME

Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization arrow_forward


12/27/2005 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3) arrow_forward


01/01/2005 - Role of transporters in drug ADME

Comparative analysis of human multidrug resistance associated protein 2 (MRP2) and rat MRP2 arrow_forward


01/01/2004 - Reviews

The role of ABC transporters in drug resistance, metabolism and toxicity arrow_forward


01/07/2001 - Role of transporters in drug ADME

Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells arrow_forward


12/31/1969 - Miscellaneous

Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties arrow_forward