Role of transporters in drug ADME

10/30/2017
Successful prediction of in vivo hepatobiliary clearances and hepatic concentrations of rosuvastatin using sandwich-cultured rat hepatocytes, transporter-expressing cell lines, and quantitative proteo arrow_forward

06/16/2017
Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice. arrow_forward

01/04/2015
Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions arrow_forward

01/01/2015
Membrane Assays to Characterize Interaction of Drugs with ABCB1 arrow_forward

03/05/2014
A P-gp vesicular transport inhibition assay - optimization and validation for drug-drug interaction testing arrow_forward

01/01/2014
Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes arrow_forward

05/11/2013
ABCG2 modulates chlorothiazide permeability—in vitro-characterization of its interactions arrow_forward

01/09/2013
Synthesis and ABCG2 inhibitory activity of novel fumitremorgin C analogs—specificity and structure activity correlations arrow_forward

01/05/2013
Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3 arrow_forward

01/01/2013
Prediction of Therapy Response and Prognosis in Leukemias by Flow Cytometric MDR Assays arrow_forward

01/01/2013
The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier arrow_forward

12/05/2012
Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences arrow_forward

05/08/2012
Digoxin is not a Substrate for Organic Anion Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a Substrate for a Sodium Dependent Transporter Expressed in HEK293 Cell arrow_forward

01/06/2012
Interactions of bilastine, a new oral H₁ antihistamine, with human transporter systems arrow_forward

01/01/2012
The vesicular transport assay: validated in vitro methods to study drug-mediated inhibition of canalicular efflux transporters ABCB11/BSEP and ABCC2/MRP2 arrow_forward

01/01/2012
The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related arrow_forward

01/01/2012
Verification of brain penetration of the unbound fraction of a novel HER2/EGFR dual kinase inhibitor (TAK-285) by microdialysis in rats arrow_forward

10/08/2011
Quinidine as an ABCB1 probe for testing drug interactions at the blood-brain barrier: an in vitro in vivo correlation study arrow_forward

09/06/2011
Calcein assay: a high-throughput method to assess P-gp inhibition arrow_forward

01/12/2011
Specific inhibition of the ABCG2 transporter could improve the efficacy of photodynamic therapy arrow_forward

01/12/2011
Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells arrow_forward

10/08/2010
ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor arrow_forward

07/12/2010
MRP2-mediated E2-17βG transport potentiation: in vitro - in vivo correlation and species specificity arrow_forward

05/11/2010
Comparison of 3 Assay Systems Using a Common Probe Substrate, Calcein AM, for Studying P-gp Using a Selected Set of Compounds arrow_forward

05/08/2010
A novel screening strategy to identify ABCB1 substrates and inhibitors arrow_forward

06/05/2009
ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions arrow_forward

06/03/2009
Characterization of 5(6)-carboxy-2,‘7’-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4 arrow_forward

05/08/2009
Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes arrow_forward

01/03/2009
Kinetic characterization of sulfasalazine transport by human ABCG2 (BCRP) arrow_forward

01/01/2009
Multidrug resistance protein 2-mediated estradiol-17beta-D-glucuronide transport potentiation: in vitro-in vivo correlation and species specificity arrow_forward

08/04/2008
Leflunomide and A771726, its metabolite are high affinity substrates of BCRP - implications for drug resistance arrow_forward

08/03/2007
Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2 arrow_forward

03/10/2007
Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp) arrow_forward

01/01/2007
In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions arrow_forward

01/01/2007
[In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions] arrow_forward

06/07/2006
Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization arrow_forward

01/01/2005
Comparative analysis of human multidrug resistance associated protein 2 (MRP2) and rat MRP2 arrow_forward

01/07/2001
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells arrow_forward