Peer Reviewed PublicationsRole of transporters in drug ADME


09/15/2021 New

Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics arrow_forward


10/09/2020

Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models arrow_forward


09/13/2020

Inhibition of ABCG2/BCRP-mediated Transport-correlation Analysis of Various Expression Systems and Probe Substrates arrow_forward


08/17/2020

Pitfalls in Predicting Hepatobiliary Drug Transport Using Human Sandwich-Cultured Hepatocytes arrow_forward


03/09/2020

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters arrow_forward


05/08/2019

A Systematic In Vitro Investigation of the Inhibitor Preincubation Effect on Multiple Classes of Clinically Relevant Transporters arrow_forward


04/05/2019

Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney arrow_forward


02/06/2019

Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics arrow_forward


02/04/2019

Involvement of Renal Efflux Transporter MATE1 in Renal Excretion of Flecainide arrow_forward


10/23/2018

Determination of Reference Values of MDR-ABC Transporter Activities in CD3+ Lymphocytes of Healthy Volunteers Using a Flow Cytometry Based Method arrow_forward


09/12/2018

Inhibitor selectivity of CNTs and ENTs arrow_forward


07/25/2018

Correlation Analysis of Potential Breast Cancer Resistance Protein Probes in Different Monolayer Systems arrow_forward


07/06/2018

Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2 arrow_forward


03/30/2018

Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001 arrow_forward


10/30/2017

Successful prediction of in vivo hepatobiliary clearances and hepatic concentrations of rosuvastatin using sandwich-cultured rat hepatocytes, transporter-expressing cell lines, and quantitative proteo arrow_forward


06/16/2017

Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice. arrow_forward


01/04/2015

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions arrow_forward


01/01/2015

Membrane Assays to Characterize Interaction of Drugs with ABCB1 arrow_forward


03/05/2014

A P-gp vesicular transport inhibition assay - optimization and validation for drug-drug interaction testing arrow_forward


01/01/2014

Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes arrow_forward


05/11/2013

ABCG2 modulates chlorothiazide permeability—in vitro-characterization of its interactions arrow_forward


01/09/2013

Synthesis and ABCG2 inhibitory activity of novel fumitremorgin C analogs—specificity and structure activity correlations arrow_forward


01/05/2013

Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3 arrow_forward


01/01/2013

Prediction of Therapy Response and Prognosis in Leukemias by Flow Cytometric MDR Assays arrow_forward


01/01/2013

The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier arrow_forward


12/05/2012

Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences arrow_forward


05/08/2012

Digoxin is not a Substrate for Organic Anion Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a Substrate for a Sodium Dependent Transporter Expressed in HEK293 Cell arrow_forward


01/06/2012

Interactions of bilastine, a new oral H₁ antihistamine, with human transporter systems arrow_forward


01/01/2012

The vesicular transport assay: validated in vitro methods to study drug-mediated inhibition of canalicular efflux transporters ABCB11/BSEP and ABCC2/MRP2 arrow_forward


01/01/2012

The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related arrow_forward


01/01/2012

Verification of brain penetration of the unbound fraction of a novel HER2/EGFR dual kinase inhibitor (TAK-285) by microdialysis in rats arrow_forward


10/08/2011

Quinidine as an ABCB1 probe for testing drug interactions at the blood-brain barrier: an in vitro in vivo correlation study arrow_forward


09/06/2011

Calcein assay: a high-throughput method to assess P-gp inhibition arrow_forward


01/12/2011

Specific inhibition of the ABCG2 transporter could improve the efficacy of photodynamic therapy arrow_forward


01/12/2011

Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells arrow_forward


10/08/2010

ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor arrow_forward


07/12/2010

MRP2-mediated E2-17βG transport potentiation: in vitro - in vivo correlation and species specificity arrow_forward


05/11/2010

Comparison of 3 Assay Systems Using a Common Probe Substrate, Calcein AM, for Studying P-gp Using a Selected Set of Compounds arrow_forward


05/08/2010

A novel screening strategy to identify ABCB1 substrates and inhibitors arrow_forward


06/05/2009

ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions arrow_forward


06/03/2009

Characterization of 5(6)-carboxy-2,‘7’-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4 arrow_forward


05/08/2009

Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes arrow_forward


01/03/2009

Kinetic characterization of sulfasalazine transport by human ABCG2 (BCRP) arrow_forward


01/01/2009

Multidrug resistance protein 2-mediated estradiol-17beta-D-glucuronide transport potentiation: in vitro-in vivo correlation and species specificity arrow_forward


08/04/2008

Leflunomide and A771726, its metabolite are high affinity substrates of BCRP - implications for drug resistance arrow_forward


08/03/2007

Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2 arrow_forward


03/10/2007

Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp) arrow_forward


01/01/2007

In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions arrow_forward


01/01/2007

[In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions] arrow_forward


06/07/2006

Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization arrow_forward


01/01/2005

Comparative analysis of human multidrug resistance associated protein 2 (MRP2) and rat MRP2 arrow_forward


01/07/2001

Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells arrow_forward