Peer Reviewed PublicationsRole of transporters in drug ADME

12/01/2023 New

Successful Prediction of Human Hepatic Concentrations of Transported Drugs Using the Proteomics-Informed Relative Expression Factor Approach

08/28/2023 New

Co-consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants

08/11/2023 New

Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice

07/08/2023 New

Interactions of the Anti-SARS-CoV-2 Agents Molnupiravir and Nirmatrelvir/Paxlovid with Human Drug Transporters

07/05/2023

In Vitro Interaction of Tetrahydrouridine with Key Human Nucleoside Transporters

06/13/2023

The Inhibitor Preincubation Effect is Universal to SLC Transporter Assays and is only Partially Eliminated in the Presence of Extracellular Protein

01/20/2023

Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk

Considerations for choosing the best in vitro system for efflux inhibition assessment. What we learned from comparing MDR1 inhibition data from multiple systems across laboratories?

11/30/2022

Modulation of Monepantel Secretion into Milk by Soy Isoflavones

09/01/2022

Prediction of Hepatobiliary Clearances and Hepatic Concentrations of Transported Drugs in Humans Using Rosuvastatin as a Model Drug

09/15/2021

Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics

10/09/2020

Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models

09/13/2020

Inhibition of ABCG2/BCRP-mediated Transport-correlation Analysis of Various Expression Systems and Probe Substrates

08/17/2020

Pitfalls in Predicting Hepatobiliary Drug Transport Using Human Sandwich-Cultured Hepatocytes

03/09/2020

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters

05/08/2019

A Systematic In Vitro Investigation of the Inhibitor Preincubation Effect on Multiple Classes of Clinically Relevant Transporters

04/05/2019

Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney

02/06/2019

Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics

02/04/2019

Involvement of Renal Efflux Transporter MATE1 in Renal Excretion of Flecainide

10/23/2018

Determination of Reference Values of MDR-ABC Transporter Activities in CD3+ Lymphocytes of Healthy Volunteers Using a Flow Cytometry Based Method

09/12/2018

Inhibitor selectivity of CNTs and ENTs

07/25/2018

Correlation Analysis of Potential Breast Cancer Resistance Protein Probes in Different Monolayer Systems

07/06/2018

Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2

03/30/2018

Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001

10/30/2017

Successful prediction of in vivo hepatobiliary clearances and hepatic concentrations of rosuvastatin using sandwich-cultured rat hepatocytes, transporter-expressing cell lines, and quantitative proteo

06/16/2017

Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice.

01/04/2015

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions

01/01/2015

Membrane Assays to Characterize Interaction of Drugs with ABCB1

03/05/2014

A P-gp vesicular transport inhibition assay - optimization and validation for drug-drug interaction testing

01/01/2014

Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes

05/11/2013

ABCG2 modulates chlorothiazide permeability—in vitro-characterization of its interactions

01/09/2013

Synthesis and ABCG2 inhibitory activity of novel fumitremorgin C analogs—specificity and structure activity correlations

01/05/2013

Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3

01/01/2013

Prediction of Therapy Response and Prognosis in Leukemias by Flow Cytometric MDR Assays

01/01/2013

The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier

12/05/2012

Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences

05/08/2012

Digoxin is not a Substrate for Organic Anion Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a Substrate for a Sodium Dependent Transporter Expressed in HEK293 Cell

01/06/2012

Interactions of bilastine, a new oral H₁ antihistamine, with human transporter systems

01/01/2012

The vesicular transport assay: validated in vitro methods to study drug-mediated inhibition of canalicular efflux transporters ABCB11/BSEP and ABCC2/MRP2

01/01/2012

The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related

01/01/2012

Verification of brain penetration of the unbound fraction of a novel HER2/EGFR dual kinase inhibitor (TAK-285) by microdialysis in rats

10/08/2011

Quinidine as an ABCB1 probe for testing drug interactions at the blood-brain barrier: an in vitro in vivo correlation study

09/06/2011

Calcein assay: a high-throughput method to assess P-gp inhibition

01/12/2011

Specific inhibition of the ABCG2 transporter could improve the efficacy of photodynamic therapy

01/12/2011

Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells

10/08/2010

ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor

07/12/2010

MRP2-mediated E2-17βG transport potentiation: in vitro - in vivo correlation and species specificity

05/11/2010

Comparison of 3 Assay Systems Using a Common Probe Substrate, Calcein AM, for Studying P-gp Using a Selected Set of Compounds

05/08/2010

A novel screening strategy to identify ABCB1 substrates and inhibitors

06/05/2009

ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions

06/03/2009

Characterization of 5(6)-carboxy-2,‘7’-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4

05/08/2009

Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes

01/03/2009

Kinetic characterization of sulfasalazine transport by human ABCG2 (BCRP)

01/01/2009

Multidrug resistance protein 2-mediated estradiol-17beta-D-glucuronide transport potentiation: in vitro-in vivo correlation and species specificity

08/04/2008

Leflunomide and A771726, its metabolite are high affinity substrates of BCRP - implications for drug resistance

08/03/2007

Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2

03/10/2007

Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)

01/01/2007

In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions

01/01/2007

[In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions]

06/07/2006

Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization

01/01/2005

Comparative analysis of human multidrug resistance associated protein 2 (MRP2) and rat MRP2

01/07/2001