01/01/2007

[In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions]

Pal A, Kis E, Mehn D, Glavinas H, Nagy T, Meszaros P, Bathori G, Krajcsi P, Falkay G. ACTA PHARM HUNG. 2007 77(4):205-16. PubMed PMID: 18290540.

Abstract

ABCG2, a transporter of the ATP-binding cassette family, is known to play a prominent role in the absorption, distribution, metabolism, and excretion of xenobiotics. Drug-transporter interactions are commonly screened by in vitro systems using transfected insect and/or human cell lines.

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