Peer Reviewed Publications

12/01/2023 - Role of transporters in drug ADME New

Successful Prediction of Human Hepatic Concentrations of Transported Drugs Using the Proteomics-Informed Relative Expression Factor Approach

08/28/2023 - Role of transporters in drug ADME New

Co-consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants

08/11/2023 - Role of transporters in drug ADME New

Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice

07/08/2023 - Role of transporters in drug ADME New

Interactions of the Anti-SARS-CoV-2 Agents Molnupiravir and Nirmatrelvir/Paxlovid with Human Drug Transporters

07/05/2023 - Role of transporters in drug ADME

In Vitro Interaction of Tetrahydrouridine with Key Human Nucleoside Transporters

06/13/2023 - Role of transporters in drug ADME

The Inhibitor Preincubation Effect is Universal to SLC Transporter Assays and is only Partially Eliminated in the Presence of Extracellular Protein

06/13/2023 - Role of transporters in drug toxicity

A Unique In Vitro Assay to Investigate ABCB4 Transport Function

01/20/2023 - Role of transporters in drug ADME

Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk

Considerations for choosing the best in vitro system for efflux inhibition assessment. What we learned from comparing MDR1 inhibition data from multiple systems across laboratories?

01/06/2023 - Miscellaneous

Toward Better Drug Development: Three-dimensional Bioprinting in Toxicological Research

12/22/2022 - Role of transporters in drug toxicity

Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing

11/30/2022 - Role of transporters in drug ADME

Modulation of Monepantel Secretion into Milk by Soy Isoflavones

09/01/2022 - Role of transporters in drug ADME

Prediction of Hepatobiliary Clearances and Hepatic Concentrations of Transported Drugs in Humans Using Rosuvastatin as a Model Drug

09/15/2021 - Miscellaneous

Modulation of Urate Transport by Drugs

09/15/2021 - Role of transporters in drug ADME

Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics

06/01/2021 - Role of transporters in drug toxicity

Quantitative Investigation of Irinotecan Metabolism, Transport and Gut Microbiome Activation

10/09/2020 - Role of transporters in drug ADME

Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models

09/13/2020 - Role of transporters in drug ADME

Inhibition of ABCG2/BCRP-mediated Transport-correlation Analysis of Various Expression Systems and Probe Substrates

08/17/2020 - Role of transporters in drug ADME

Pitfalls in Predicting Hepatobiliary Drug Transport Using Human Sandwich-Cultured Hepatocytes

07/11/2020 - Reviews

Prediction of Drug-Induced Hyperbilirubinemia by In Vitro Testing

06/25/2020 - Miscellaneous

Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake of Glucuronide Metabolites of Androgens

03/09/2020 - Role of transporters in drug ADME

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters

07/30/2019 - Reviews

Age-Related Functional and Expressional Changes in Efflux Pathways at the Blood-Brain Barrier

05/08/2019 - Role of transporters in drug ADME

A Systematic In Vitro Investigation of the Inhibitor Preincubation Effect on Multiple Classes of Clinically Relevant Transporters

04/05/2019 - Role of transporters in drug ADME

Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney

03/16/2019 - Reviews

ABCG2/BCRP: variants, transporter interaction profile of substrates and inhibitors

02/06/2019 - Role of transporters in drug ADME

Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics

02/04/2019 - Role of transporters in drug ADME

Involvement of Renal Efflux Transporter MATE1 in Renal Excretion of Flecainide

02/01/2019 - Role of transporters in drug toxicity

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

10/23/2018 - Role of transporters in drug ADME

Determination of Reference Values of MDR-ABC Transporter Activities in CD3+ Lymphocytes of Healthy Volunteers Using a Flow Cytometry Based Method

09/12/2018 - Role of transporters in drug ADME

Inhibitor selectivity of CNTs and ENTs

08/15/2018 - Miscellaneous

The oncomir face of microRNA-206: A permanent miR-206 transfection study

07/25/2018 - Role of transporters in drug ADME

Correlation Analysis of Potential Breast Cancer Resistance Protein Probes in Different Monolayer Systems

07/06/2018 - Role of transporters in drug ADME

Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2

06/19/2018 - Role of transporters in drug toxicity

Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency

06/11/2018 - Role of transporters in drug toxicity

Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides

06/05/2018 - Miscellaneous

Third-generation Sequencing Reveals Extensive Polycistronism and Transcriptional Overlapping in a Baculovirus

03/30/2018 - Role of transporters in drug ADME

Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001

10/30/2017 - Role of transporters in drug ADME

Successful prediction of in vivo hepatobiliary clearances and hepatic concentrations of rosuvastatin using sandwich-cultured rat hepatocytes, transporter-expressing cell lines, and quantitative proteo

10/09/2017 - Role of transporters in drug toxicity

Kinetic characterization of bile salt transport by human NTCP (SLC10A1)

08/26/2017 - Miscellaneous

Species specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2)

07/26/2017 - Miscellaneous

First cloned human immortalized adipose derived mesenchymal stem-cell line with chimeric SS18-SSX1 gene (SS-iASC)

07/24/2017 - Miscellaneous

Optimization and Application of a Biotinylation Method for Quantification of Plasma Membrane Expression of Transporters in Cells

06/16/2017 - Role of transporters in drug ADME

Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice.

05/04/2017 - Miscellaneous

Repeated-dose toxicity of common ragweed on rats

01/01/2016 - Reviews

Investigating ABCB1-Mediated Drug-Drug Interactions: Considerations for In vitro and In vivo Assay Design

01/01/2016 - Reviews

Membrane Transporters in Physiological Barriers of Pharmacological Importance

03/05/2015 - Reviews

MDR-ABC transporters: biomarkers in rheumatoid arthritis

01/04/2015 - Role of transporters in drug ADME

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions

01/01/2015 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Multiple ABC Transporters Efflux Baicalin

01/01/2015 - Role of transporters in drug ADME

Membrane Assays to Characterize Interaction of Drugs with ABCB1

01/01/2015 - Reviews

Mechanisms and therapeutic potential of inhibiting drug efflux transporters

01/01/2015 - Reviews

Pre-Plated Cell Lines for ADMETox Applications in the Pharmaceutical Industry

09/09/2014 - Miscellaneous

mRNA levels of related Abcb genes change opposite to each other upon histone deacetylase inhibition in drug-resistant rat hepatoma cells

05/04/2014 - Reviews

In vitro methods in drug transporter interaction assessment

03/05/2014 - Role of transporters in drug ADME

A P-gp vesicular transport inhibition assay - optimization and validation for drug-drug interaction testing

01/01/2014 - Role of transporters in drug ADME

Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes

01/01/2014 - Reviews

Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics

09/03/2013 - Reviews

Drug-transporter interaction testing in drug discovery and development

05/11/2013 - Role of transporters in drug ADME

ABCG2 modulates chlorothiazide permeability—in vitro-characterization of its interactions

01/09/2013 - Role of transporters in drug ADME

Synthesis and ABCG2 inhibitory activity of novel fumitremorgin C analogs—specificity and structure activity correlations

01/05/2013 - Role of transporters in drug ADME

Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3

01/01/2013 - Role of transporters in drug ADME

Prediction of Therapy Response and Prognosis in Leukemias by Flow Cytometric MDR Assays

01/01/2013 - Role of transporters in drug ADME

The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier

12/05/2012 - Role of transporters in drug ADME

Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences

06/11/2012 - Role of transporters in drug toxicity

BSEP inhibition – in vitro screens to assess cholestatic potential of drugs.

05/08/2012 - Role of transporters in drug ADME

Digoxin is not a Substrate for Organic Anion Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a Substrate for a Sodium Dependent Transporter Expressed in HEK293 Cell

01/06/2012 - Role of transporters in drug ADME

Interactions of bilastine, a new oral H₁ antihistamine, with human transporter systems

01/04/2012 - Reviews

Efflux transporters in the blood-brain interfaces—in vitro and in vivo methods and correlations

01/01/2012 - Role of transporters in drug ADME

The vesicular transport assay: validated in vitro methods to study drug-mediated inhibition of canalicular efflux transporters ABCB11/BSEP and ABCC2/MRP2

01/01/2012 - Role of transporters in drug ADME

The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related

01/01/2012 - Role of transporters in drug ADME

Verification of brain penetration of the unbound fraction of a novel HER2/EGFR dual kinase inhibitor (TAK-285) by microdialysis in rats

10/08/2011 - Role of transporters in drug ADME

Quinidine as an ABCB1 probe for testing drug interactions at the blood-brain barrier: an in vitro in vivo correlation study

09/06/2011 - Role of transporters in drug ADME

Calcein assay: a high-throughput method to assess P-gp inhibition

05/12/2011 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters

01/12/2011 - Role of transporters in drug ADME

Specific inhibition of the ABCG2 transporter could improve the efficacy of photodynamic therapy

01/12/2011 - Role of transporters in drug ADME

Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells

01/01/2011 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Ivermectin interacts with human ABCG2.

10/08/2010 - Role of transporters in drug ADME

ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor

07/12/2010 - Role of transporters in drug ADME

MRP2-mediated E2-17βG transport potentiation: in vitro - in vivo correlation and species specificity

05/11/2010 - Role of transporters in drug ADME

Comparison of 3 Assay Systems Using a Common Probe Substrate, Calcein AM, for Studying P-gp Using a Selected Set of Compounds

05/08/2010 - Role of transporters in drug ADME

A novel screening strategy to identify ABCB1 substrates and inhibitors

01/08/2010 - Reviews

ABCC2/Abcc2: a multispecific transporter with dominant excretory functions

12/12/2009 - Reviews

Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays

12/09/2009 - Miscellaneous

Characterisation of a GroEL Single-Ring Mutant that Supports Growth of Escherichia coli and Has GroES-Dependent ATPase Activity

11/06/2009 - Role of transporters in drug toxicity

Effect of membrane cholesterol on BSEP/Bsep activity - species specificity studies for substrates and inhibitors

09/11/2009 - Role of transporters in drug toxicity

Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs

09/04/2009 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Mechanistic study on the intestinal absorption and disposition of baicalein

06/05/2009 - Role of transporters in drug ADME

ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions

06/03/2009 - Role of transporters in drug ADME

Characterization of 5(6)-carboxy-2,‘7’-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4

05/08/2009 - Role of transporters in drug ADME

Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes

02/03/2009 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Specific interactions of chloroacetanilide herbicides with human ABC transporter proteins

01/12/2009 - Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1

01/11/2009 - Reviews

Potentiation of MRP2/Mrp2-mediated estradiol-17beta-glucuronide transport by drugs—a concise review

01/03/2009 - Role of transporters in drug ADME

Kinetic characterization of sulfasalazine transport by human ABCG2 (BCRP)

01/03/2009 - Reviews

Interaction of macrocyclic lactones with the multidrug transporters: the bases of the pharmacokinetics of lipid-like drugs

01/01/2009

Kinetic characterization of sulfasalazine transport by human ATP-binding cassette G2

01/01/2009 - Role of transporters in drug ADME

Multidrug resistance protein 2-mediated estradiol-17beta-D-glucuronide transport potentiation: in vitro-in vivo correlation and species specificity

08/04/2008 - Role of transporters in drug ADME

Leflunomide and A771726, its metabolite are high affinity substrates of BCRP - implications for drug resistance

01/06/2008 - Reviews

Utilization of membrane vesicle preparations to study drug-ABC transporter interactions

08/03/2007 - Role of transporters in drug ADME

Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2