JPN
search Search About SOLVO Regulatory Guidance Grants account_circle Customer Login
Solvo Biotechnology Logo
  • Products & Serviceskeyboard_arrow_down
  • Knowledge Centerkeyboard_arrow_down
  • News & Eventskeyboard_arrow_down
  • Contactkeyboard_arrow_down

Transporter Products

  • Membrane Preparations
  • Uptake Transporter Kits
  • Efflux Transporter Kits
  • Ready-to-use Monolayers
  • HepatoPac®
  • Licensing
  • Other Products
  • Search for Datasheet

Transporter Services

  • Uptake Transporter Services
  • Efflux Transporter Services
  • Caco-2 Services
  • Hepatocyte Uptake Assays
  • Lysosomal Trapping Assays
  • Hepatic Kp,uu Determination
  • Proximal Tubule Cell Monolayer Assays
  • B-Clear® assays
  • DILIScreen Services

Metabolism Services

  • CYP450 Inhibition
  • CYP450 Induction
  • CYP450 Phenotyping
  • Metabolic Stability
  • UGT Inhibition

Related Information

  • Recent Developments
  • Search by Transporters
  • Technologies
  • SOLVO inputs from DILIsym
  • Charles River Products & Services

Transporter Book 4th edition

  • 63 transporters
  • over 1500 references
  • comprehensive information on holistic models and proteomics for transporter research
  • changes in the regulatory landscape and scientific insights

Get the Book

Meet the Experts Webinars

  • Previousarrow_forward
    Evolving Approaches on Measurements and Applications of Intracellular Free Drug Concentration and Kpuu in Drug Discovery
  • Previousarrow_forward
    MDR1 Promotes Intrinsic and Acquired Resistance to PROTACs in Cancer Cells – a Case Report
  • View All arrow_forward

Downloads

  • Decision Trees
  • Brochures
  • Posters
  • Presentations
  • Barrier images
  • Financial information

More

  • Peer Reviewed Publications
  • Science Letter
  • Transporters A-Z
  • FAQ
  • ReACTS

News

  • Full in Vitro DDI Package, Improved Hepatocyte Assays and more News & Developments!
  • New Metabolism Service, Publications and Webinars from SOLVO!
  • Webinar announcement - 21 March - Proteomics-informed Modeling Reveals Glucuronidation as a Transport Mechanism for Drugs and Endobiotics
  • New Peer Reviewed Publications - SPOTLIGHT - Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk

Meet the Experts Transporter Conferences

As a pioneer in the drug transporter field for 20 years, SOLVO is dedicated to exploring the science of transporters and their role in xenobiotic efficacy and safety.

Subscribe

SOLVO Transporter News featuring new products & services announcements, events, publications

SOLVO Science Letters including the latest research results by our R&D department

Sign up

Branches

  • Europe
  • North America
  • Japan
  • Asia-Pacific

Distributors

  • Japan
  • Republic of Korea
  • North America

Contact Form

Request Consultancy Service, Questions about Products and Services, Media Relations, or General Inquiry use our Contact Form

Contact Solvo

Careers

  • Junior Trainee Program
  • About SOLVO Biotechnology
  • Charles River Laboratories
  • Mission Statement
  • Quality Policy
  • Why SOLVO
  • Leadership
  • Awards & Prizes
  • Grants
  • Scientific Background

Take home messages from the ITC papers

The potential for drug-drug interactions (DDIs) involving membrane transporters has become an area of intense regulatory review over the past seven years.

Regulatory Guidance for Drug Interaction Studies

SOLVO Transporter Studies for Regulatory Submission. Regulatory Requirements. SOLVO solutions and capabilities. Transporter Decision Trees.

  • arrow_forward Products & Services
  • arrow_forward Knowledge Center
  • arrow_forward Regulatory Guidance
  • arrow_forward News & Events
  • arrow_forward About SOLVO
  • arrow_forward Contact
  • arrow_forward Grants
  • Peer Reviewed PublicationsSubmenu
  • arrow_forward Reviews
  • arrow_forward Role of transporters in drug ADME New
  • arrow_forward Role of transporters in drug toxicity New
  • arrow_forward Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants
  • arrow_forward Miscellaneous New
  • arrow_forward Book chapters
  • Home
  • Knowledge Center
  • Peer Reviewed Publications

Peer Reviewed PublicationsRole of transporters in drug toxicity


06/13/2023

A Unique In Vitro Assay to Investigate ABCB4 Transport Function arrow_forward


12/22/2022

Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing arrow_forward


06/01/2021

Quantitative Investigation of Irinotecan Metabolism, Transport and Gut Microbiome Activation arrow_forward


02/01/2019

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury arrow_forward


06/19/2018

Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency arrow_forward


06/11/2018

Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides arrow_forward


10/09/2017

Kinetic characterization of bile salt transport by human NTCP (SLC10A1) arrow_forward


06/11/2012

BSEP inhibition – in vitro screens to assess cholestatic potential of drugs. arrow_forward


11/06/2009

Effect of membrane cholesterol on BSEP/Bsep activity - species specificity studies for substrates and inhibitors arrow_forward


09/11/2009

Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs arrow_forward




share Share this page

Get in touch
for a quote or for a meeting!
  • Contact
  • Contact Form
  • Europe
  • North America
  • Japan
  • Asia-Pacific
  • Sales Representatives
  • Distributors
  • Japan
  • Republic of Korea
  • North America
  • Sitemap
  • About Solvo
  • Products & Service
  • Knowledge Center
  • Regulatory Guidance
  • News & Events
  • Customer Login
  • Registration
  • Sitemap
  • Legal
  • Privacy policy
  • Copyright
  • Terms of use
  • Follow us:
  • Facebook
  • LinkedIn
  • Twitter
  • © Solvo Biotechnology, 2025 - All rights reserved