HepatoPac is a unique Micro-Patterned Co-Culture of hepatocytes and fibroblasts. SOLVO offers the following services on HepatoPac® plates:
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The potential for drug-drug interactions (DDIs) involving membrane transporters has become an area of intense regulatory review over the past seven years.
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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury arrow_forward
Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency arrow_forward
Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides arrow_forward
Kinetic characterization of bile salt transport by human NTCP (SLC10A1) arrow_forward
BSEP inhibition – in vitro screens to assess cholestatic potential of drugs. arrow_forward
Effect of membrane cholesterol on BSEP/Bsep activity - species specificity studies for substrates and inhibitors arrow_forward
Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs arrow_forward
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