05/04/2014 - Reviews

In vitro methods in drug transporter interaction assessment

Márton Jani, Péter Krajcsi, In vitro methods in drug transporter interaction assessment, Drug Discovery Today: Technologies. 5 April 2014


Drug transporter proteins recruit to pharmacological barrier tissues and profoundly affect the ADME properties of a large number of drugs. In vitroassays optimized for drug transporters have grown into routine tools in the determination of molecular level interactions as well as prediction of barrier penetration and system level pharmacokinetics. Regulatory position mandates increasing interest in the application of these assays during drug development.

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