01/01/2007 - Role of transporters in drug ADME
In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions
Pál A, Kis E, Méhn D, Glavinas H, Nagy T, Mészáros P, Báthori G, Krajcsi P, Falkay G
Acta Pharm Hung. 2007;77(4):205-16.
Abstract
ABCG2, a transporter of the ATP-binding cassette family, is known to play a prominent role in the absorption, distribution, metabolism, and excretion of xenobiotics. Drug-transporter interactions are commonly screened by in vitro systems using transfected insect and/or human cell lines.
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