|Service||Cell Line||Transporter||Technology||Membrane Type||Probe Substrate||Read Out||Reference Inhibitor||Positive Control||Dynamic Range|
Monolayers based on Caco-2 cells (a human colon carcinoma cell line) express a wide range of transporter proteins on its cell membranes similar to those of intestinal endothelium cells (Siissalo S et al. 2007, Calcagno AM et al. 2006), thus this cell line is ideal for intestinal absorption simulations. In fact, in the last decade, the utilization of Caco-2 cells has become an industry standard for the investigation of intestinal absorption, permeability and drug-drug interactions (DDIs) (Oh DM et al. 2002.).
1. Basic - Studies at one concentration
2. Extended - Studies at several concentrations, more controls
3. FDA Guidelines - Studies according to FDA draft guidance (2006)
Learn more about the Caco2 Monolayer services.